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Chemical Compound Review

AGN-PC-00H0QE     3,4,5-trihydroxypentan-2-one

Synonyms: CPD-1093, AC1L190J, 1-deoxypent-2-ulose, (3S,4R)-3,4,5-trihydroxypentan-2-one
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Disease relevance of CPD-1093


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Chemical compound and disease context of CPD-1093


Anatomical context of CPD-1093


Gene context of CPD-1093

  • Administration of deuterium labeled 1-deoxy-d-xylulose and mevalolactone to lima beans (Phaseolus lunatus), followed by gas chromatographic separation and mass spectrometric analysis of de novo produced volatiles revealed that the strict separation of both pathways does not exist [10].


  1. Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein. Hecht, S., Eisenreich, W., Adam, P., Amslinger, S., Kis, K., Bacher, A., Arigoni, D., Rohdich, F. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. Biosynthesis of vitamin B6 in Rhizobium: in vitro synthesis of pyridoxine from 1-deoxy-D-xylulose and 4-hydroxy-L-threonine. Tazoe, M., Ichikawa, K., Hoshino, T. Biosci. Biotechnol. Biochem. (2002) [Pubmed]
  3. Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. Rohdich, F., Hecht, S., Gärtner, K., Adam, P., Krieger, C., Amslinger, S., Arigoni, D., Bacher, A., Eisenreich, W. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. A cytosolic Arabidopsis d-xylulose kinase catalyzes the phosphorylation of 1-deoxy-d-xylulose into a precursor of the plastidial isoprenoid pathway. Hemmerlin, A., Tritsch, D., Hartmann, M., Pacaud, K., Hoeffler, J.F., van Dorsselaer, A., Rohmer, M., Bach, T.J. Plant Physiol. (2006) [Pubmed]
  5. Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein. Laber, B., Maurer, W., Scharf, S., Stepusin, K., Schmidt, F.S. FEBS Lett. (1999) [Pubmed]
  6. (-)-2C-methyl-D-erythrono-1,4-lactone is formed after application of the terpenoid precursor 1-deoxy-D-xylulose. Fellermeier, M.A., Maier, U.H., Sagner, S., Bacher, A., Zenk, M.H. FEBS Lett. (1998) [Pubmed]
  7. Phosphorylation of 1-deoxy-D-xylulose by D-xylulokinase of Escherichia coli. Wungsintaweekul, J., Herz, S., Hecht, S., Eisenreich, W., Feicht, R., Rohdich, F., Bacher, A., Zenk, M.H. Eur. J. Biochem. (2001) [Pubmed]
  8. Novel sugar phosphotransferase system applicable to the efficient labeling of the compounds synthesized via the non-mevalonate pathway in Escherichia coli. Hemmi, H., Yamashita, S., Nakayama, T., Nishino, T. J. Biosci. Bioeng. (2002) [Pubmed]
  9. Vgamma9/Vdelta2 T cell activation induced by bacterial low molecular mass compounds depends on the 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid biosynthesis. Jomaa, H., Feurle, J., Lühs, K., Kunzmann, V., Tony, H.P., Herderich, M., Wilhelm, M. FEMS Immunol. Med. Microbiol. (1999) [Pubmed]
  10. Dynamic pathway allocation in early terpenoid biosynthesis of stress-induced lima bean leaves. Bartram, S., Jux, A., Gleixner, G., Boland, W. Phytochemistry (2006) [Pubmed]
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