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Chemical Compound Review

FMOC     9H-fluoren-9-ylmethyl chloromethanoate

Synonyms: Fmoc-Cl, Fmoc-chloride, Fmoc chloride, PubChem10485, CCRIS 2608, ...
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High impact information on CCRIS 2608

  • Proteins, transferred onto polyvinylidene (PVDF) membranes, were submitted to vapor-phase hydrolysis, derivatized with 9-fluorenylmethyl chloroformate (FMOC) and separated on an ODS-Hypersil column [1].
  • Direct enantiomeric separations of some racemic amino acids derivatized with 9-fluorenylmethyl chloroformate were obtained using cyclodextrin-modified micellar electrokinetic chromatography (CD/MEKC) with a buffer made up of 5 mM sodium borate (pH 9.2), 150 mM sodium dodecyl sulfate (SDS) and 40 mM gamma-CD [2].
  • Quantification of fudosteine in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry employing precolumn derivatization with 9-fluorenylmethyl chloroformate [3].
  • The method involves a derivatization step with 9-fluorenylmethyl chloroformate (FMOC-Cl) in borate buffer and detection based on high-performance liquid chromatography-electrospray ionization mass spectrometry (LC/ESI/MS) [3].
  • The analyte is then selectively retained on a precolumn (20 mm x 2.1 mm i.d., packed with 30 microm, Hypersil C18 phase), and derivatized on-line by injecting 9-fluorenylmethyl chloroformate (FMOC) [4].

Associations of CCRIS 2608 with other chemical compounds


Gene context of CCRIS 2608


Analytical, diagnostic and therapeutic context of CCRIS 2608


  1. Identification of proteins by their amino acid composition: an evaluation of the method. Golaz, O., Wilkins, M.R., Sanchez, J.C., Appel, R.D., Hochstrasser, D.F., Williams, K.L. Electrophoresis (1996) [Pubmed]
  2. Enantiomeric separation of amino acids using micellar electrokinetic chromatography after pre-column derivatization with the chiral reagent 1-(9-fluorenyl)-ethyl chloroformate. Chan, K.C., Muschik, G.M., Issaq, H.J. Electrophoresis (1995) [Pubmed]
  3. Quantification of fudosteine in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry employing precolumn derivatization with 9-fluorenylmethyl chloroformate. Xu, F., Zhang, Z., Jiao, H., Tian, Y., Zhang, B., Chen, Y. Journal of mass spectrometry : JMS. (2006) [Pubmed]
  4. Selective determination of trimethylamine in air by liquid chromatography using solid phase extraction cartridges for sampling. Cháfer-Pericás, C., Herráez-Hernández, R., Campíns-Falcó, P. Journal of chromatography. A. (2004) [Pubmed]
  5. Derivatization of tertiary amphetamines with 9-fluorenylmethyl chloroformate for liquid chromatography: determination of N-methylephedrine. Herráez-Hernández, R., Campíns-Falcó, P. The Analyst. (2000) [Pubmed]
  6. Measurement of histidinohydroxylysinonorleucine and hydroxyproline in skin collagen by reversed-phase high-performance liquid chromatography after 9-fluorenylmethyl chloroformate labeling. Kondo, A., Ishikawa, O., Okada, K., Miyachi, Y., Abe, S., Kuboki, Y. Anal. Biochem. (1997) [Pubmed]
  7. Separation and quantitative analysis of O-linked phosphoamino acids by isocratic high-performance liquid chromatography of the 9-fluorenylmethyl chloroformate derivatives. Niedbalski, J.S., Ringer, D.P. Anal. Biochem. (1986) [Pubmed]
  8. The determination of 4-amino-1-hydroxybutane-1,1-diphosphonic acid monosodium salt trihydrate in pharmaceutical dosage forms by high-performance liquid chromatography. De Marco, J.D., Biffar, S.E., Reed, D.G., Brooks, M.A. Journal of pharmaceutical and biomedical analysis. (1989) [Pubmed]
  9. High-performance liquid chromatography/fluorescence detection of S-methylglutathione formed by glutathione-S-transferase T1 in vitro. Müller, M., Voss, M., Heise, C., Schulz, T., Bünger, J., Hallier, E. Arch. Toxicol. (2001) [Pubmed]
  10. High galactosylation of oligosaccharides in umbilical cord blood IgG, and its relationship to placental function. Kimura, S., Numaguchi, M., Kaizu, T., Kim, D., Takagi, Y., Gomi, K. Clin. Chim. Acta (2000) [Pubmed]
  11. 3-Hydroxylysine, a potential marker for studying radical-induced protein oxidation. Morin, B., Bubb, W.A., Davies, M.J., Dean, R.T., Fu, S. Chem. Res. Toxicol. (1998) [Pubmed]
  12. Amino acid analysis of collagen hydrolysates by reverse-phase high-performance liquid chromatography of 9-fluorenylmethyl chloroformate derivatives. Miller, E.J., Narkates, A.J., Niemann, M.A. Anal. Biochem. (1990) [Pubmed]
  13. Laser-induced fluorescence detection of 9-fluorenylmethyl chloroformate derivatized amino acids in capillary electrophoresis. Chan, K.C., Janini, G.M., Muschik, G.M., Issaq, H.J. Journal of chromatography. A. (1993) [Pubmed]
  14. Analysis of human beta-endorphin 28-31 (melanotropin potentiating factor) and analogues by high-performance liquid chromatography of their 9-fluorenylmethoxycarbonyl derivatives. Lewis, J.R., Morley, J.S., Venn, R.F. J. Chromatogr. (1993) [Pubmed]
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