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Chemical Compound Review

Cleanal     (2S)-2-amino-3-(3- hydroxypropylsulfanyl)pr...

Synonyms: Fudostein, Spelear, Fudosteine, Cleanal (TN), S2129_Selleck, ...
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Disease relevance of Fudosteine


High impact information on Fudosteine


Biological context of Fudosteine

  • We examined the effect of fudosteine ((-)-(R)-2-amino-3-(3-hydroxypropylthio)propionic acid) on the mucociliary transport (MCT) rate in quails [3].
  • Noncompartmental analysis was used for the calculation of the total area under the plasma concentration-time curve (AUC) from time zero to time infinity and the terminal half-life (t1/2) of fudosteine [4].

Anatomical context of Fudosteine


Gene context of Fudosteine

  • Plasma harvested from the blood was separated and analyzed for fudosteine levels by a validated high-performance liquid chromatography-electrospray ionization mass spectrometry (HPLC/ESI/MS) method employing percolumn derivatization with 9-fluorenylmethyl chloroformate (FMOC-Cl) [4].


  1. Inhibition of endotoxin- and antigen-induced airway inflammation by fudosteine, a mucoactive agent. Komatsu, H., Yamaguchi, S., Komorita, N., Goto, K., Takagi, S., Ochi, H., Okumoto, T. Pulmonary pharmacology & therapeutics. (2005) [Pubmed]
  2. Quantification of fudosteine in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry employing precolumn derivatization with 9-fluorenylmethyl chloroformate. Xu, F., Zhang, Z., Jiao, H., Tian, Y., Zhang, B., Chen, Y. Journal of mass spectrometry : JMS. (2006) [Pubmed]
  3. Effect of fudosteine, a new cysteine derivative, on mucociliary transport. Takahashi, K., Kai, H., Mizuno, H., Koda, T., Miyata, T. J. Pharm. Pharmacol. (2001) [Pubmed]
  4. The pharmacokinetics of orally administered fudosteine in healthy Chinese volunteers. Jiao, H.Y., Zhang, Z.J., Xu, F.G., Tian, Y., Zhang, B.B., Chen, Y. European journal of drug metabolism and pharmacokinetics. (2006) [Pubmed]
  5. Effects of SS320A, a new cysteine derivative, on the change in the number of goblet cells induced by isoproterenol in rat tracheal epithelium. Takahashi, K., Mizuno, H., Ohno, H., Kai, H., Isohama, Y., Takahama, K., Nagaoka, S., Miyata, T. Jpn. J. Pharmacol. (1998) [Pubmed]
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