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Chemical Compound Review:

Cleanal (2S)-2-amino-3-(3- hydroxypropylsulfanyl)pr...

Synonyms: Fudostein, Spelear, Fudosteine, Cleanal (TN), S2129_Selleck, ...

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Disease relevance of Fudosteine

These results suggest that inflammatory events including neutrophil chemoattractant production and neutrophil migration play important roles for goblet cell hyperplasia in endotoxin-induced airway inflammation, and fudosteine inhibits goblet cell hyperplasia by inhibiting GRO/CINC-1 production and/or neutrophil migration [1].

High impact information on Fudosteine

The proposed method has been successfully applied to study the pharmacokinetics of fudosteine in healthy Chinese volunteers after single and multiple oral administration [2].
Quantification of fudosteine in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry employing precolumn derivatization with 9-fluorenylmethyl chloroformate [2].
Fudosteine significantly inhibited increases in GRO/CINC-1 at 10-100 mg/kg, and neutrophils and goblet cells at 30 and 100 mg/kg [1].
Furthermore, fudosteine (100 mg/kg) inhibited ovalbumin-induced eosinophil infiltration into BALF, suggesting it attenuates asthmatic inflammation [1].
However, topical application of fudosteine to the tracheal mucosa dose-dependently protected the impairment of the MCT rate caused by exposure to cigarette smoke [3].

Biological context of Fudosteine

We examined the effect of fudosteine ((-)-(R)-2-amino-3-(3-hydroxypropylthio)propionic acid) on the mucociliary transport (MCT) rate in quails [3].
Noncompartmental analysis was used for the calculation of the total area under the plasma concentration-time curve (AUC) from time zero to time infinity and the terminal half-life (t1/2) of fudosteine [4].

Anatomical context of Fudosteine

Effects of SS320A, a new cysteine derivative, on the change in the number of goblet cells induced by isoproterenol in rat tracheal epithelium [5].

Gene context of Fudosteine

Plasma harvested from the blood was separated and analyzed for fudosteine levels by a validated high-performance liquid chromatography-electrospray ionization mass spectrometry (HPLC/ESI/MS) method employing percolumn derivatization with 9-fluorenylmethyl chloroformate (FMOC-Cl) [4].

References

Inhibition of endotoxin- and antigen-induced airway inflammation by fudosteine, a mucoactive agent. Komatsu, H., Yamaguchi, S., Komorita, N., Goto, K., Takagi, S., Ochi, H., Okumoto, T. Pulmonary pharmacology & therapeutics. (2005) [Pubmed]
Quantification of fudosteine in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry employing precolumn derivatization with 9-fluorenylmethyl chloroformate. Xu, F., Zhang, Z., Jiao, H., Tian, Y., Zhang, B., Chen, Y. Journal of mass spectrometry : JMS. (2006) [Pubmed]
Effect of fudosteine, a new cysteine derivative, on mucociliary transport. Takahashi, K., Kai, H., Mizuno, H., Koda, T., Miyata, T. J. Pharm. Pharmacol. (2001) [Pubmed]
The pharmacokinetics of orally administered fudosteine in healthy Chinese volunteers. Jiao, H.Y., Zhang, Z.J., Xu, F.G., Tian, Y., Zhang, B.B., Chen, Y. European journal of drug metabolism and pharmacokinetics. (2006) [Pubmed]
Effects of SS320A, a new cysteine derivative, on the change in the number of goblet cells induced by isoproterenol in rat tracheal epithelium. Takahashi, K., Mizuno, H., Ohno, H., Kai, H., Isohama, Y., Takahama, K., Nagaoka, S., Miyata, T. Jpn. J. Pharmacol. (1998) [Pubmed]

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