Disease relevance of N-Methylephedrine

• There is no evidence in any of these cases that methylephedrine was present at toxic concentrations; therefore, it appears from the cases reviewed in this study that blood methylephedrine concentrations less than 0.3 mg/L are not associated with significant toxicity [1].
• More than 20 mg/kg body weight of M-711 was effective in relieving the asthmatic symptoms like methylephedrine [2].

Psychiatry related information on N-Methylephedrine

• Conditions for the derivatization were investigated, including the reaction time, the derivatization reagent concentration and the pH, using N-methylephedrine as a model compound [3].

High impact information on N-Methylephedrine

• Two stacking methods of capillary electrophoresis (CE) were developed for the separation of very dilute solutions of ephedra-alkaloids, namely ephedrine, pseudoephedrine, methylephedrine, methylpseudoephedrine, norephedrine, and norpseudoephedrine [4].
• 1. Urinary metabolites of methylephedrine and their excretion after oral administration to rat and human volunteers have been studied [5].
• N-oxidation and N-demethylation of methylephedrine by rat-liver microsomes [6].
• Assessment of antihistaminic and antimuscarinic effects of optical isomers of ephedrine and methylephedrine by receptor binding assay in guinea pig ileal muscle [7].

Analytical, diagnostic and therapeutic context of N-Methylephedrine

• A new and rapid analytical method for the simultaneous determination of six EPHEDRA alkaloids (ephedrine, pseudoephedrine, norephedrine, norpseudoephedrine, methylephedrine, and methylpseudoephedrine) in Ephedrae Herba by high performance liquid chromatography (HPLC) has been developed [8].

References