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Chemical Compound Review

Citnatin     trisodium 2-hydroxypropane-1,2,3...

Synonyms: Citreme, Citrosodna, Citrosodina, Citrosodine, Natrocitral, ...
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Disease relevance of citric acid


High impact information on citric acid


Chemical compound and disease context of citric acid


Biological context of citric acid


Anatomical context of citric acid


Associations of citric acid with other chemical compounds


Gene context of citric acid

  • Crystals of human RCC1 suitable for X-ray analysis have been obtained using the seeding technique in hanging drops with sodium citrate as a precipitant [26].
  • VEGF was not different and PF4 was very low or undetectable in Edinburgh plasma and CTAD plasma, while it was significantly higher in sodium citrate plasma [27].
  • BTG and PF4 release from blood anticoagulated with sodium citrate was inhibited by AD6 during a 3 h incubation [28].
  • Crystals of yeast IDH have been obtained and optimized using sodium citrate, a competitive inhibitor of the enzyme, as the precipitating agent [29].
  • A new assay was developed, and the following steady-state kinetic constants were determined for 1-deoxy-D-xylulose 5-phosphate synthase A and B: K(m)(pyruvate) = 0.61 and 3.0 mM, K(m)(D-glyceraldehyde 3-phosphate) = 150 and 120 microM, and V(max) = 1.9 and 1.4 micromol/min/mg in 200 mM sodium citrate (pH 7.4) [30].

Analytical, diagnostic and therapeutic context of citric acid


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  2. IscA mediates iron delivery for assembly of iron-sulfur clusters in IscU under the limited accessible free iron conditions. Ding, H., Clark, R.J., Ding, B. J. Biol. Chem. (2004) [Pubmed]
  3. Metabolic alkalosis due to plasmapheresis. Pearl, R.G., Rosenthal, M.H. Am. J. Med. (1985) [Pubmed]
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  5. Heat serum inactivation as a mandatory procedure for antiactin antibody detection in cell culture. Cançado, E.L., Vilas-Boas, L.S., Abrantes-Lemos, C.P., Novo, N.F., Porta, G., Da Silva, L.C., Laudanna, A.A. Hepatology (1996) [Pubmed]
  6. Randomized, clinical trial comparison of trisodium citrate 30% and heparin as catheter-locking solution in hemodialysis patients. Weijmer, M.C., van den Dorpel, M.A., Van de Ven, P.J., ter Wee, P.M., van Geelen, J.A., Groeneveld, J.O., van Jaarsveld, B.C., Koopmans, M.G., le Poole, C.Y., Schrander-Van der Meer, A.M., Siegert, C.E., Stas, K.J. J. Am. Soc. Nephrol. (2005) [Pubmed]
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  8. Crystallization and preliminary X-ray diffraction studies of the enoyl-ACP reductase from Escherichia coli. Wagner, U.G., Bergler, H., Fuchsbichler, S., Turnowsky, F., Högenauer, G., Kratky, C. J. Mol. Biol. (1994) [Pubmed]
  9. Crystallization and preliminary X-ray crystallographic analysis of lipase from Pseudomonas cepacia. Kim, K.K., Hwang, K.Y., Jeon, H.S., Kim, S., Sweet, R.M., Yang, C.H., Suh, S.W. J. Mol. Biol. (1992) [Pubmed]
  10. Simplified citrate anticoagulation for continuous renal replacement therapy. Tolwani, A.J., Campbell, R.C., Schenk, M.B., Allon, M., Warnock, D.G. Kidney Int. (2001) [Pubmed]
  11. 1-Desamino-8-D-arginine vasopressin (DDAVP) infusion in type IIB von Willebrand's disease: shortening of bleeding time and induction of a variable pseudothrombocytopenia. Casonato, A., Sartori, M.T., de Marco, L., Girolami, A. Thromb. Haemost. (1990) [Pubmed]
  12. Platelet aggregation inhibitory effects of the new positive inotropic agents pimobendan and UD CG 212 in whole blood. Saniabadi, A.R., Lowe, G.D., Belch, J.J., Forbes, C.D. Cardiovasc. Res. (1989) [Pubmed]
  13. A comparison of two sodium citrate concentrations in two evacuated blood collection systems for prothrombin time and ISI determination. van den Besselaar, A.M., Chantarangkul, V., Tripodi, A. Thromb. Haemost. (2000) [Pubmed]
  14. Assessment of platelet activation in several different anticoagulants by the Advia 120 Hematology System, fluorescence flow cytometry, and electron microscopy. Ahnadi, C.E., Sabrinah Chapman, E., Lépine, M., Okrongly, D., Pujol-Moix, N., Hernández, A., Boughrassa, F., Grant, A.M. Thromb. Haemost. (2003) [Pubmed]
  15. Effective charge on acetylcholinesterase active sites determined from the ionic strength dependence of association rate constants with cationic ligands. Nolte, H.J., Rosenberry, T.L., Neumann, E. Biochemistry (1980) [Pubmed]
  16. The behavior of chick gastrula mesodermal cells under the unidirectional tractive force parallel to the substrata. Toyoizumi, R., Takeuchi, S. J. Cell. Sci. (1995) [Pubmed]
  17. The effect of sodium citrate on the stimulation of polymorphonuclear leukocytes. Parker, A.V., Williams, R.N., Paterson, C.A. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
  18. Effect of high protein diet on stone-forming propensity and bone loss in rats. Amanzadeh, J., Gitomer, W.L., Zerwekh, J.E., Preisig, P.A., Moe, O.W., Pak, C.Y., Levi, M. Kidney Int. (2003) [Pubmed]
  19. Formation of a cryogel during processing of cell-free plasma. Rock, G., Palmer, D., Tittley, P., McCombie, N., Schoendorfer, D., Drago, J. Transfusion (1989) [Pubmed]
  20. A nylon wool filter coated with human immunoglobulin for rapid depletion of monocytes and myeloid cells from peripheral blood stem cell transplants. Kwekkeboom, J., Buurman, D.E., Ploemacher, R.E., Baars, J.W., Loos, H.A., Slaper-Cortenbach, I.C. Exp. Hematol. (1998) [Pubmed]
  21. Salt sensitivity in humans is associated with abnormal acid-base regulation. Sharma, A.M., Kribben, A., Schattenfroh, S., Cetto, C., Distler, A. Hypertension (1990) [Pubmed]
  22. Whole blood storage in citrate and phosphate solutions containing half-strength trisodium citrate: cellular and biochemical studies. Mishler, J.M., Darley, J.H., Cederholm-Williams, S., Wright, G. J. Pathol. (1978) [Pubmed]
  23. Effects of sodium salts on pressor reactivity in salt-sensitive men. Sharma, A.M., Schattenfroh, S., Thiede, H.M., Oelkers, W., Distler, A. Hypertension (1992) [Pubmed]
  24. Accurate determination of human serum transferrin isoforms: exploring metal-specific isotope dilution analysis as a quantitative proteomic tool. Busto, M.E., Montes-Bay??n, M., Sanz-Medel, A. Anal. Chem. (2006) [Pubmed]
  25. Enantiomeric separation of amino acids using micellar electrokinetic chromatography after pre-column derivatization with the chiral reagent 1-(9-fluorenyl)-ethyl chloroformate. Chan, K.C., Muschik, G.M., Issaq, H.J. Electrophoresis (1995) [Pubmed]
  26. Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation. Renault, L., Nassar, N., Wittinghofer, A., Roth, M., Vetter, I.R. Acta Crystallogr. D Biol. Crystallogr. (1999) [Pubmed]
  27. Validation of blood collection procedures for the determination of circulating vascular endothelial growth factor (VEGF) in different blood compartments. Dittadi, R., Meo, S., Fabris, F., Gasparini, G., Contri, D., Medici, M., Gion, M. Int. J. Biol. Markers (2001) [Pubmed]
  28. Action of AD6 (8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxycarbonylmet hox y coumarin) on human platelets in vitro. Prosdocimi, M., Zatta, A., Gorio, A., Zanetti, A., Dejana, E. Naunyn Schmiedebergs Arch. Pharmacol. (1986) [Pubmed]
  29. Crystallization and preliminary X-ray crystallographic analysis of yeast NAD+-specific isocitrate dehydrogenase. Hu, G., Taylor, A.B., McAlister-Henn, L., Hart, P.J. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2005) [Pubmed]
  30. 1-Deoxy-D-xylulose 5-phosphate synthase, the gene product of open reading frame (ORF) 2816 and ORF 2895 in Rhodobacter capsulatus. Hahn, F.M., Eubanks, L.M., Testa, C.A., Blagg, B.S., Baker, J.A., Poulter, C.D. J. Bacteriol. (2001) [Pubmed]
  31. Oral rehydration therapy: efficacy of sodium citrate equals to sodium bicarbonate for correction of acidosis in diarrhoea. Islam, M.R., Samadi, A.R., Ahmed, S.M., Bardhan, P.K., Ali, A. Gut (1984) [Pubmed]
  32. Pre-nucleation crystallization studies on aminoacyl-tRNA synthetases by dynamic light-scattering. Thibault, F., Langowski, J., Leberman, R. J. Mol. Biol. (1992) [Pubmed]
  33. Regional citrate anticoagulation in continuous venovenous hemofiltration in critically ill patients with a high risk of bleeding. Palsson, R., Niles, J.L. Kidney Int. (1999) [Pubmed]
  34. Alterations of platelet aggregation kinetics with ultraviolet laser emission: the "stunned platelet" phenomenon. Topaz, O., Minisi, A.J., Bernardo, N.L., McPherson, R.A., Martin, E., Carr, S.L., Carr, M.E. Thromb. Haemost. (2001) [Pubmed]
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