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Chemical Compound Review

AGN-PC-008BYU     1-[2-hydroxy-4-[(2-hydroxy- 2,3-dihydro-1H...

Synonyms: AG-K-58379, SureCN1176257, NSC-740136, CTK7J6701, NSC740136, ...
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Disease relevance of Crixivan

  • These results confirmed the significance of indan oxide formation and identified the hydrolysis of indan oxide as a key step in maximizing the production of (2R)-indandiol, a chiral precursor of the HIV protease inhibitor, Crixivan [1].
  • The bionconversion of indene to cis-(1S,2R)-indandiol, a potential key intermediate in the synthesis of Merck's HIV protease inhibitor, CRIXIVAN trade mark, can be achieved using Rhodococcus, Pseudomonas putida, and Escherichia coli strains [2].
  • The ACS award for Creative Invention went to researchers at Merck and Co Inc, who successfully developed Crixivan (indinavir, L-735524), an HIV-1 protease inhibitor, which received FDA approval in record time and is now used by over 300,000 patients worldwide [3].
  • Case no. 3. Right flank pain. Crixivan lithiasis [4].

High impact information on Crixivan


  1. Application of radiolabeled tracers to biocatalytic flux analysis. Yanagimachi, K.S., Stafford, D.E., Dexter, A.F., Sinskey, A.J., Drew, S., Stephanopoulos, G. Eur. J. Biochem. (2001) [Pubmed]
  2. Measurement of strain-dependent toxicity in the indene bioconversion using multiparameter flow cytometry. Amanullah, A., Hewitt, C.J., Nienow, A.W., Lee, C., Chartrain, M., Buckland, B.C., Drew, S.W., Woodley, J.M. Biotechnol. Bioeng. (2003) [Pubmed]
  3. Division of Medicinal Chemistry--general oral session/fellowship awards. Agathangelou, P. IDrugs : the investigational drugs journal. (1999) [Pubmed]
  4. Case no. 3. Right flank pain. Crixivan lithiasis. Schenkman, N.S. Techniques in urology. (1999) [Pubmed]
  5. Comparable pharmacokinetics of generic indinavir (Inhibisam) versus brand indinavir (Crixivan) when boosted with ritonavir. Zala, C., Alexander, C.S., Ochoa, C., Guillemi, S., Ting, L.S., Bonner, S., Cahn, P., Harrigan, P.R., Montaner, J.S. J. Acquir. Immune Defic. Syndr. (2005) [Pubmed]
  6. In vitro metabolism of indinavir in the human fetal liver microsomes. Chiba, M., Nshime, J.A., Lin, J.H. Drug Metab. Dispos. (1997) [Pubmed]
  7. Comparative in vitro metabolism of indinavir in primates--a unique stereoselective hydroxylation in monkey. Chiba, M., Nishime, J.A., Neway, W., Lin, Y., Lin, J.H. Xenobiotica (2000) [Pubmed]
  8. Crixivan side effect update - hair loss and ingrown toenails. Fornataro, K., Jefferys, R. The Body positive. (1999) [Pubmed]
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