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Chemical Compound Review

Auristatin PE     2-[[(2S)-2-dimethylamino-3- methyl...

Synonyms: NSC-654663, AC1L8BOD, NSC654663, NCI60_018912
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Disease relevance of NSC654663


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Biological context of NSC654663


Anatomical context of NSC654663


Gene context of NSC654663


Analytical, diagnostic and therapeutic context of NSC654663


  1. Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1. Mohammad, R.M., Varterasian, M.L., Almatchy, V.P., Hannoudi, G.N., Pettit, G.R., Al-Katib, A. Clin. Cancer Res. (1998) [Pubmed]
  2. A new tubulin polymerization inhibitor, auristatin PE, induces tumor regression in a human Waldenstrom's macroglobulinemia xenograft model. Mohammad, R.M., Limvarapuss, C., Wall, N.R., Hamdy, N., Beck, F.W., Pettit, G.R., Al-Katib, A. Int. J. Oncol. (1999) [Pubmed]
  3. Induction of growth inhibition and apoptosis in pancreatic cancer cells by auristatin-PE and gemcitabine. Li, Y., Singh, B., Ali, N., Sarkar, F.H. Int. J. Mol. Med. (1999) [Pubmed]
  4. Effects of the antimitotic natural product dolastatin 10, and related peptides, on the human malarial parasite Plasmodium falciparum. Fennell, B.J., Carolan, S., Pettit, G.R., Bell, A. J. Antimicrob. Chemother. (2003) [Pubmed]
  5. Modulation of cIAP-1 by novel antitubulin agents when combined with bryostatin 1 results in increased apoptosis in the human early pre-B acute lymphoblastic leukemia cell line Reh. Wall, N.R., Mohammad, R.M., Nabha, S.M., Pettit, G.R., Al-Katib, A.M. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  6. Bax:Bcl-2 ratio modulation by bryostatin 1 and novel antitubulin agents is important for susceptibility to drug induced apoptosis in the human early pre-B acute lymphoblastic leukemia cell line, Reh. Wall, N.R., Mohammad, R.M., Al-Katib, A.M. Leuk. Res. (1999) [Pubmed]
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