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Chemical Compound Review:

AG-A-37022 2-(aminomethyl)-5-hydroxy- pyran-4-one

Synonyms: Kojic amine, AC1Q6BXO, CTK7E4004, AR-1D8841, AKOS006282159, ...

Beart, P.M. et al., Bousquet, P. et al., Downing, S.S. et al., Martin, G.E. et al., Yarbrough, G.G. et al.

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High impact information on Kojic amine

Consistent with this prediction, diazepam increased the efficacy of the GABA(A) receptor partial agonist kojic amine in chick spinal cord neurons [1].
[3H]GABA binding studies revealed that THIP and kojic amine, but not baclofen or gamma-acetylenic GABA, produced large increases in [3H]GABA 'A' binding (150 and 228% of control respectively) which were attributable to altered densities of binding sites without changes in affinity [2].
The combination of bicuculline and kainic acid almost completely prevented the blood pressure lowering effects of muscimol, kojic amine and isoguvacine [3].
The neuropharmacology of a novel gamma-aminobutyric acid analog, kojic amine [4].

Analytical, diagnostic and therapeutic context of Kojic amine

The unilateral intranigral microinjection of kojic amine elicited dose-related turning contraversive from the injection site [5].

References

Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation. Downing, S.S., Lee, Y.T., Farb, D.H., Gibbs, T.T. Br. J. Pharmacol. (2005) [Pubmed]
Subchronic administration of GABAergic agonists elevates [3H]GABA binding and produces tolerance in striatal dopamine catabolism. Beart, P.M., Scatton, B., Lloyd, K.G. Brain Res. (1985) [Pubmed]
Pharmacological analysis of the central cardiovascular effects of four GABA analogues. Bousquet, P., Feldman, J., Bloch, R., Schwartz, J. Naunyn Schmiedebergs Arch. Pharmacol. (1984) [Pubmed]
The neuropharmacology of a novel gamma-aminobutyric acid analog, kojic amine. Yarbrough, G.G., Williams, M., Haubrich, D.R. Archives internationales de pharmacodynamie et de thérapie. (1979) [Pubmed]
Further evidence for a GABA-like action on kojic amine. Martin, G.E., Bendesky, R.J. Neurosci. Lett. (1981) [Pubmed]

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