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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

AC1L8RPB     6-chloro-5H-purine

Synonyms:
 
 
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Disease relevance of SK 6048

  • Most of the synthesized compounds exhibited toxicity-dependent anti-HIV-1 activity, among which 6-chloropurine derivative was found to be the most cytotoxic and showed good cytotoxicity against colon cancer cell lines [1].
 

High impact information on SK 6048

 

Biological context of SK 6048

 

Associations of SK 6048 with other chemical compounds

  • The stability of S-(purin-6-yl)-L-cysteine (SPC), a kidney-selective prodrug of 6-mercaptopurine and a putative metabolite of 6-chloropurine, was investigated under various pH and temperature conditions [8].
  • The chemical modification of bovine pancreatic ribonuclease A by 6-chloropurine riboside was studied to obtain information about the role of the purine nucleoside moiety of the ribonucleic acid in the enzyme-substrate interaction [9].
 

Gene context of SK 6048

 

Analytical, diagnostic and therapeutic context of SK 6048

References

  1. Synthesis and biological evaluation of novel thioapio dideoxynucleosides. Moon, H.R., Kim, H.O., Lee, S.K., Choi, W.J., Chun, M.W., Jeong, L.S. Bioorg. Med. Chem. (2002) [Pubmed]
  2. Traceless solid-phase synthesis of N1,N7-disubstituted purines. Fu, H., Lam, Y. Journal of combinatorial chemistry. (2005) [Pubmed]
  3. 1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes. Kim, H.O., Schinazi, R.F., Nampalli, S., Shanmuganathan, K., Cannon, D.L., Alves, A.J., Jeong, L.S., Beach, J.W., Chu, C.K. J. Med. Chem. (1993) [Pubmed]
  4. 6-(Alkylamino)-9-benzyl-9H-purines. A new class of anticonvulsant agents. Kelley, J.L., Krochmal, M.P., Linn, J.A., McLean, E.W., Soroko, F.E. J. Med. Chem. (1988) [Pubmed]
  5. Conformationally constrained purine mimics. Incorporation of adenine and guanine into spirocyclic nucleosides. Paquette, L.A., Kahane, A.L., Seekamp, C.K. J. Org. Chem. (2004) [Pubmed]
  6. Asymmetric synthesis of novel thioiso dideoxynucleosides with exocyclic methylene as potential antiviral agents. Gunaga, P., Baba, M., Jeong, L.S. J. Org. Chem. (2004) [Pubmed]
  7. Adenylate deaminase. A method for its localization in skeletal muscle. Nakatsu, K. J. Histochem. Cytochem. (1975) [Pubmed]
  8. Effects of pH, temperature, and chemical structure on the stability of S-(purin-6-yl)-L-cysteine: evidence for a novel molecular rearrangement mechanism to yield N-(purin-6-yl)-L-cysteine. Elfarra, A.A., Hwang, I.Y. Chem. Res. Toxicol. (1996) [Pubmed]
  9. Modification of bovine pancreatic ribonuclease A with 6-chloropurine riboside. Alonso, J., Nogués, M.V., Cuchillo, C.M. Arch. Biochem. Biophys. (1986) [Pubmed]
  10. In vitro ultrastructural localization of the catalytic activity of adenosine deaminase in murine C-1300 neuroblastoma. Bielat, K.L., Tritsch, G., Chervinsky, D. Cancer Detect. Prev. (1990) [Pubmed]
  11. Adenosine deaminase activity associated with phagocytic vacuoles. Cytochemical demonstration by electron microscopy. Tritsch, G.L., Paolini, N.S., Bielat, K. Histochemistry (1985) [Pubmed]
 
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