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Chemical Compound Review

Diglycerin     3-(2,3- dihydroxypropoxy)propane-1,2- diol

Synonyms: Diglycerol, Diglycerine, AGN-PC-00MWOJ, NSC-8689, NSC8689, ...
 
 
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Disease relevance of Diglycerine

  • Protein stabilization by compatible solutes. Effect of diglycerol phosphate on the dynamics of Desulfovibrio gigas rubredoxin studied by NMR [1].
 

High impact information on Diglycerine

  • The lipids of nine different methanogenic bacterial strains are comprised of diphytanyl glycerol diethers, previously known only in extremely halophilic bacterial, as well as dibiphytanyl diglycerol tetraethers, known formerly only in the extremely thermoacidophilic bacteria Thermoplasma and Sulfolobus [2].
  • The stabilizing effect of diglycerol phosphate on rubredoxin is demonstrated and assessed by determining selected amide proton exchange rates; diglycerol phosphate at 100 mM concentration caused an additional structural stabilization of 1.2 +/-0.4 kJ/mol [3].
  • Mixed micelles composed of a mixture of lipids, i.e. diglycerol hexadecylether (C16G2), cholesterol (CHOL), dicetylphosphate (DCP) and detergent, octylglucoside (OG), were diluted with detergent-free buffer added either instantaneously or progressively at different rates ranging from 3.47 x 10(-2) to 6.94 x 10(-4) ml/min [4].
  • The mixing of the different bilayer components was studied by monitoring the excimer fluorescence of pyrene-labelled polymeric vesicles after their encapsulation within egg PC liposomes or hexadecyl diglycerol ether niosomes [5].
  • The roles of lysophosphatide acyltransferase, transacylase and diglycerol acyltransferase in the distribution of arachidonate in tick salivary glands are discussed [6].
 

Biological context of Diglycerine

 

Analytical, diagnostic and therapeutic context of Diglycerine

References

  1. Protein stabilization by compatible solutes. Effect of diglycerol phosphate on the dynamics of Desulfovibrio gigas rubredoxin studied by NMR. Lamosa, P., Turner, D.L., Ventura, R., Maycock, C., Santos, H. Eur. J. Biochem. (2003) [Pubmed]
  2. Diphytanyl and dibiphytanyl glycerol ether lipids of methanogenic archaebacteria. Tornabene, T.G., Langworthy, T.A. Science (1979) [Pubmed]
  3. NMR structure of Desulfovibrio gigas rubredoxin: a model for studying protein stabilization by compatible solutes. Lamosa, P., Brennan, L., Vis, H., Turner, D.L., Santos, H. Extremophiles (2001) [Pubmed]
  4. Reconstitution of non-ionic monoalkyl amphiphile-cholesterol vesicles by dilution of lipids-octylglucoside mixed micelles. Seras, M., Ollivon, M., Edwards, K., Lesieur, S. Chem. Phys. Lipids (1993) [Pubmed]
  5. Liposomes encapsulating polymeric chitosan based vesicles--a vesicle in vesicle system for drug delivery. McPhail, D., Tetley, L., Dufes, C., Uchegbu, I.F. International journal of pharmaceutics. (2000) [Pubmed]
  6. Uptake, incorporation and redistribution of arachidonic acid in isolated salivary glands of the lone star tick. Bowman, A.S., Dillwith, J.W., Madden, R.D., Sauer, J.R. Insect Biochem. Mol. Biol. (1995) [Pubmed]
  7. Influence of cell differentiation and protein kinase C activation on sub-cellular distribution of beta-N-acetylhexosaminidases of HL 60 cells. Emiliani, C., Martino, S., Stirling, J.L., Orlacchio, A. Physiological chemistry and physics and medical NMR. (1995) [Pubmed]
  8. Novel sustained-release dosage forms of proteins using polyglycerol esters of fatty acids. Yamagata, Y., Iga, K., Ogawa, Y. Journal of controlled release : official journal of the Controlled Release Society. (2000) [Pubmed]
 
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