Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN50310 [(2R,3S,4S,5R)-3,4,5- trihydroxy-6-oxo-oxan...

Synonyms: CHEBI:16938, HMDB01127, AC1L97DQ, C01236, 6-Pgdl, ...

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Disease relevance of D-glucono-delta-lactone-6-phosphate

Phospho-beta-glucosidase from Fusobacterium mortiferum: purification, cloning, and inactivation by 6-phosphoglucono-delta-lactone [1].

High impact information on D-glucono-delta-lactone-6-phosphate

A spectrophotometric assay for 6-phosphogluconolactonase involving the use of immobilized enzymes to prepare the labile 6-phosphoglucono-delta-lactone substrate [2].
This is likely due to poor growth of Bgl+ pgl strains on salicin due to the accumulation of 6-phosphogluconolactone [3].
It is hypothesized that as the PPP is inhibited by metabolites of 6-AN in the neocortex, glycolysis is inhibited in a proportionate manner through an inhibitory effect on phosphoglucose isomerase by 6-phosphogluconate and/or 6-phosphoglucono-delta-lactone [4].
The extent of purification and the kinetic properties of the enzyme were evaluated with an optical test that was based on the hydrolysis of synthetic 6-phosphogluconolactone [5].
It is concluded that 6-phosphogluconolactone (and in particular, one of its isomeric forms) is a highly electrophilic compound, and may possibly react with sundry intracellular nucleophiles, thereby exerting untoward metabolic effects [6].

Biological context of D-glucono-delta-lactone-6-phosphate

Thus, it appears that the same active site on the enzyme binds glucose-6-phosphate in the forward reaction and 6-phosphogluconolactone in the reverse reaction.(ABSTRACT TRUNCATED AT 250 WORDS)[7]

Gene context of D-glucono-delta-lactone-6-phosphate

The natural product of the glucose-6-phosphate dehydrogenase reaction is 6-phosphoglucono-delta-lactone, which must be hydrolyzed to 6-phosphogluconic acid before it can be further metabolized by 6-phosphogluconate dehydrogenase [8].
In all cases the activities of 6 phosphogluconolactone (6PGL) and glutathione reductase (GR) were normal, and the molecular characterization performed in the partially purified 6PGD from the propositus showed normal kinetic and electrophoretic patterns [9].

References

Phospho-beta-glucosidase from Fusobacterium mortiferum: purification, cloning, and inactivation by 6-phosphoglucono-delta-lactone. Thompson, J., Robrish, S.A., Bouma, C.L., Freedberg, D.I., Folk, J.E. J. Bacteriol. (1997) [Pubmed]
A spectrophotometric assay for 6-phosphogluconolactonase involving the use of immobilized enzymes to prepare the labile 6-phosphoglucono-delta-lactone substrate. Moir, R.D., Stokes, G.B. Biochem. J. (1988) [Pubmed]
Identification of the Escherichia coli K-12 ybhE gene as pgl, encoding 6-phosphogluconolactonase. Thomason, L.C., Court, D.L., Datta, A.R., Khanna, R., Rosner, J.L. J. Bacteriol. (2004) [Pubmed]
6-Aminonicotinamide inhibition of the pentose phosphate pathway in rat neocortex. Tyson, R.L., Perron, J., Sutherland, G.R. Neuroreport (2000) [Pubmed]
6-phosphogluconolactonase. Purification, properties and activities in various tissues. Bauer, H.P., Srihari, T., Jochims, J.C., Hofer, H.W. Eur. J. Biochem. (1983) [Pubmed]
Reactivity of 6-phosphogluconolactone with hydroxylamine: the possible involvement of glucose-6-phosphate dehydrogenase in endogenous glycation reactions. Rakitzis, E.T., Papandreou, P. Chem. Biol. Interact. (1998) [Pubmed]
Characteristics and significance of the reverse glucose-6-phosphate dehydrogenase reaction. Beutler, E., Kuhl, W. J. Lab. Clin. Med. (1986) [Pubmed]
Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism. Beutler, E., Kuhl, W. J. Lab. Clin. Med. (1985) [Pubmed]
Congenital 6-phosphogluconate dehydrogenase (6PGD) deficiency associated with chronic hemolytic anemia in a Spanish family. Vives Corrons, J.L., Colomer, D., Pujades, A., Rovira, A., Aymerich, M., Merino, A., Aguilar i Bascompte, J.L. Am. J. Hematol. (1996) [Pubmed]

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