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Gene Review

PGD  -  phosphogluconate dehydrogenase

Homo sapiens

Synonyms: 6-phosphogluconate dehydrogenase, decarboxylating, PGDH
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Disease relevance of PGD


Psychiatry related information on PGD


High impact information on PGD

  • Our studies have shown that responsiveness of amnion, a key intrauterine tissue, to interleukin-1beta is abrogated by inhibition of histone deacetylation, whereas PGDH amounts were increased basally [6].
  • Proinsulin and insulin exerted similar maximal stimulatory effects on glycogen synthesis and on the activities of pyruvate kinase, glucose 6-phosphate dehydrogenase, phosphogluconate dehydrogenase, and malic enzyme [7].
  • To study the interaction of P(4) and F on the regulation of PGDH, we treated chorion and placental trophoblast cells in culture with combinations of F, dexamethasone, P(4), trilostane, and medroxyprogesterone acetate (MPA) [8].
  • F and dexamethasone decreased PGDH activity and mRNA levels [8].
  • Exogenous P(4) did not significantly alter PGDH activity or mRNA levels; however, MPA significantly stimulated PGDH activity [8].

Chemical compound and disease context of PGD


Biological context of PGD


Anatomical context of PGD


Associations of PGD with chemical compounds


Other interactions of PGD


Analytical, diagnostic and therapeutic context of PGD


  1. Diverse origins of multiple ovarian teratomas in a single individual. Carritt, B., Parrington, J.M., Welch, H.M., Povey, S. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  2. D-3-Phosphoglycerate dehydrogenase from Mycobacterium tuberculosis is a link between the Escherichia coli and mammalian enzymes. Dey, S., Hu, Z., Xu, X.L., Sacchettini, J.C., Grant, G.A. J. Biol. Chem. (2005) [Pubmed]
  3. 15-hydroxyprostaglandin dehydrogenase: implications in preterm labor with and without ascending infection. van Meir, C.A., Matthews, S.G., Keirse, M.J., Ramirez, M.M., Bocking, A., Challis, J.R. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  4. Genetic relationships among phlebotomine sand flies (Diptera: Psychodidae) in the verrucarum species group. Kreutzer, R.D., Palau, M.T., Morales, A., Ferro, C., Feliciangeli, D., Young, D.G. J. Med. Entomol. (1990) [Pubmed]
  5. Evidence for several fold more activity of NAD+-dependent uterine prostaglandin 15-hydroxydehydrogenase in transsexual than in non-transsexual women. Roy, A.C., Sen, D.K., Ratnam, S.S. Prostaglandins (1989) [Pubmed]
  6. Unique suppression of prostaglandin H synthase-2 expression by inhibition of histone deacetylation, specifically in human amnion but not adjacent choriodecidua. Mitchell, M.D. Mol. Biol. Cell (2006) [Pubmed]
  7. Regulation of ketogenesis, gluconeogenesis, and glycogen synthesis by insulin and proinsulin in rat hepatocyte monolayer cultures. Agius, L., Chowdhury, M.H., Davis, S.N., Alberti, K.G. Diabetes (1986) [Pubmed]
  8. Cortisol/progesterone antagonism in regulation of 15-hydroxysteroid dehydrogenase activity and mRNA levels in human chorion and placental trophoblast cells at term. Patel, F.A., Challis, J.R. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  9. Decreased gene expression of 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase in human placenta of patients with preeclampsia. Schoof, E., Girstl, M., Frobenius, W., Kirschbaum, M., Dörr, H.G., Rascher, W., Dötsch, J. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  10. Combined phenotyping of glucose 6-phosphate dehydrogenase (G6PD; EC and 6-phosphogluconate dehydrogenase (PDG; EC Marbach, A. Forensic Sci. Int. (1986) [Pubmed]
  11. Genetic markers in the blood of three species of tamarins (Saguinus mystax, S. labiatus and S. oedipus). Nagai, A., Shimaoka, T., Lee, S.C., Ikemoto, S. Jikken Dobutsu (1986) [Pubmed]
  12. Identification of a cDNA encoding 6-phosphogluconate dehydrogenase from a human heart cDNA library. Tsui, S.K., Chan, J.Y., Waye, M.M., Fung, K.P., Lee, C.Y. Biochem. Genet. (1996) [Pubmed]
  13. Towards multilocus sequence typing of the Leishmania donovani complex: resolving genotypes and haplotypes for five polymorphic metabolic enzymes (ASAT, GPI, NH1, NH2, PGD). Mauricio, I.L., Yeo, M., Baghaei, M., Doto, D., Pratlong, F., Zemanova, E., Dedet, J.P., Lukes, J., Miles, M.A. Int. J. Parasitol. (2006) [Pubmed]
  14. Phosphoglucomutase1 and 6-phosphogluconate dehydrogenase types in human skin and adipose tissue. Katsumata, Y., Ito, H., Aoki, M., Tsutsumi, H., Sato, K., Oya, M., Suzuki, O., Yada, S. J. Forensic Sci. (1982) [Pubmed]
  15. PGD phenotyping in bloodstains, organ tissues, dental pulps and hair roots by isoelectric focusing. Komatsu, N., Kido, A., Kimura, Y., Oya, M. Forensic Sci. Int. (1990) [Pubmed]
  16. Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism. Beutler, E., Kuhl, W. J. Lab. Clin. Med. (1985) [Pubmed]
  17. Activity of some enzymes of carbohydrate metabolism in human subcutaneous adipose tissue in newborns, infants and adults. I. Activity of pyruvate kinase, lactate dehydrogenase, glucose-6-phosphate dehydrogenase and phosphogluconate dehydrogenase. Willgerodt, H., Vízek, K., Rázová, M., Melichar, V. Biol. Neonate (1975) [Pubmed]
  18. Phosphoglucomutase1 (PGM1) and 6-phosphogluconate dehydrogenase (PGD) types in the human hairbulb. Oya, M., Ito, H., Kido, A., Suzuki, O., Katsumata, Y., Yada, S. Forensic science. (1978) [Pubmed]
  19. Low allozyme variability in Bactrocera albistrigata (Insecta: Diptera: Tephritidae) from Peninsular Malaysia. Yong, H.S. Comp. Biochem. Physiol., B (1990) [Pubmed]
  20. Maleimide as an inhibitor in measurement of erythrocyte glucose-6-phosphate dehydrogenase activity. Deutsch, J. Clin. Chem. (1978) [Pubmed]
  21. A rare fast variant of red cell 6-phosphogluconate dehydrogenase found in Japanese. Tsunoda, K., Douge, K., Kuroiwa, Y., Watanabe, S., Watanabe, T. Nippon Hoigaku Zasshi (1989) [Pubmed]
  22. Linkage of two enzyme loci in the fish genus Poecilia (Teleostei:Poeciliidae). Narine, K.M., Kallman, K.D., Walter, R.B., Morizot, D.C. Cytogenet. Cell Genet. (1992) [Pubmed]
  23. Red-cell enzyme polymorphisms in Ibiza (Balearic Islands, Spain). Miguel, A., Petitpierre, E. Hum. Hered. (1989) [Pubmed]
  24. Linkage groups of protein-coding genes in western palearctic water frogs reveal extensive evolutionary conservation. Hotz, H., Uzzell, T., Berger, L. Genetics (1997) [Pubmed]
  25. Adaptational changes in kinetic parameters of G6PDH but not of PGDH during contamination-induced carcinogenesis in livers of North Sea flatfish. Van Noorden, C.J., Bahns, S., Köhler, A. Biochim. Biophys. Acta (1997) [Pubmed]
  26. Biochemical identities and differences among Leishmania species and subspecies. Kreutzer, R.D., Souraty, N., Semko, M.E. Am. J. Trop. Med. Hyg. (1987) [Pubmed]
  27. NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase: immunochemical characterization of the lung enzyme from pregnant rabbits. Okita, R.T., Sinning, A.R., Okita, J.R., Tai, H.H., Markwald, R.R., Bergholte, J.M. Arch. Biochem. Biophys. (1990) [Pubmed]
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