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Gene Review

PGLS  -  6-phosphogluconolactonase

Homo sapiens

Synonyms: 6PGL
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Disease relevance of PGLS


High impact information on PGLS


Biological context of PGLS


Associations of PGLS with chemical compounds


  1. Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1). Collard, F., Collet, J.F., Gerin, I., Veiga-da-Cunha, M., Van Schaftingen, E. FEBS Lett. (1999) [Pubmed]
  2. 6-Phosphogluconolactonase deficiency, a hereditary erythrocyte enzyme deficiency: possible interaction with glucose-6-phosphate dehydrogenase deficiency. Beutler, E., Kuhl, W., Gelbart, T. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  3. Computer simulation of the metabolic consequences of the combined deficiency of 6-phosphogluconolactonase and glucose-6-phosphate dehydrogenase in human erythrocytes. Thorburn, D.R., Kuchel, P.W. J. Lab. Clin. Med. (1987) [Pubmed]
  4. Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes. Fratelli, M., Demol, H., Puype, M., Casagrande, S., Eberini, I., Salmona, M., Bonetto, V., Mengozzi, M., Duffieux, F., Miclet, E., Bachi, A., Vandekerckhove, J., Gianazza, E., Ghezzi, P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase. Miclet, E., Stoven, V., Michels, P.A., Opperdoes, F.R., Lallemand, J.Y., Duffieux, F. J. Biol. Chem. (2001) [Pubmed]
  6. A spectrophotometric assay for 6-phosphogluconolactonase involving the use of immobilized enzymes to prepare the labile 6-phosphoglucono-delta-lactone substrate. Moir, R.D., Stokes, G.B. Biochem. J. (1988) [Pubmed]
  7. Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism. Beutler, E., Kuhl, W. J. Lab. Clin. Med. (1985) [Pubmed]
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