Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

CTK2G1150 4,6-dioxohept-2-enedioic acid

Synonyms: AC1L97SZ, 75164-75-9, 2-Heptenedioic acid, 4,6-dioxo-, (2Z)-

Feng, J. et al., Uchihashi, K. et al., Stolz, A. et al., Werwath, J. et al., Shen, X.H. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Maleylpyruvic acid

This mycothiol-dependent maleylpyruvate isomerase gene (ncgl2918) was cloned, actively expressed, and purified from Escherichia coli [1].
The Gene ncgl2918 Encodes a Novel Maleylpyruvate Isomerase That Needs Mycothiol as Cofactor and Links Mycothiol Biosynthesis and Gentisate Assimilation in Corynebacterium glutamicum [1].
Purification and some properties of maleylpyruvate hydrolase and fumarylpyruvate hydrolase from Pseudomonas alcaligenes [2].
Glutathione-independent isomerization of maleylpyruvate by Bacillus megaterium and other gram-positive bacteria [3].

High impact information on Maleylpyruvic acid

The Ncg12921 was able to up-regulate gentisate 1,2-dioxygenase, maleylpyruvate isomerase, and fumarylpyruvate hydrolase activities [4].
The purified enzyme stoichiometrically converted gentisate to maleylpyruvate, which was identified by gas chromatography-mass spectrometry analysis as its methyl ester [5].
An intermediate chlorolactone apparently lost chloride by enzymatic hydrolysis with formation of maleylpyruvate [6].
2,4-Dihydroxybenzoate 1-monooxygenase, 1,2,4-trihydroxybenzene 1,2-dioxygenase and maleylpyruvate reductase were induced in Pseudomonas sp. BN9 after growth with 2,4-dihydroxybenzoate [7].

Analytical, diagnostic and therapeutic context of Maleylpyruvic acid

When the resting cells of NDS2-008 were incubated with 5SSA or gentisate, a substance deduced to be maleylpyruvate (Zhou et al., J. Bacteriol., 183, 700-708, 2001) was commonly detected upon HPLC analysis [8].

References

The Gene ncgl2918 Encodes a Novel Maleylpyruvate Isomerase That Needs Mycothiol as Cofactor and Links Mycothiol Biosynthesis and Gentisate Assimilation in Corynebacterium glutamicum. Feng, J., Che, Y., Milse, J., Yin, Y.J., Liu, L., Rückert, C., Shen, X.H., Qi, S.W., Kalinowski, J., Liu, S.J. J. Biol. Chem. (2006) [Pubmed]
Purification and some properties of maleylpyruvate hydrolase and fumarylpyruvate hydrolase from Pseudomonas alcaligenes. Bayly, R.C., Chapman, P.J., Dagley, S., Di Berardino, D. J. Bacteriol. (1980) [Pubmed]
Glutathione-independent isomerization of maleylpyruvate by Bacillus megaterium and other gram-positive bacteria. Hagedorn, S.R., Bradley, G., Chapman, P.J. J. Bacteriol. (1985) [Pubmed]
Functional identification of novel genes involved in the glutathione-independent gentisate pathway in Corynebacterium glutamicum. Shen, X.H., Jiang, C.Y., Huang, Y., Liu, Z.P., Liu, S.J. Appl. Environ. Microbiol. (2005) [Pubmed]
Biochemical and genetic characterization of a gentisate 1, 2-dioxygenase from Sphingomonas sp. strain RW5. Werwath, J., Arfmann, H.A., Pieper, D.H., Timmis, K.N., Wittich, R.M. J. Bacteriol. (1998) [Pubmed]
Catabolism of 5-chlorosalicylate by a Bacillus isolated from the Mississippi River. Crawford, R.L., Olson, P.E., Frick, T.D. Appl. Environ. Microbiol. (1979) [Pubmed]
Degradation of 2,4-dihydroxybenzoate by Pseudomonas sp. BN9. Stolz, A., Knackmuss, H.J. FEMS Microbiol. Lett. (1993) [Pubmed]
Mutational analysis of the metabolism of 2,6-naphthalenedisulfonate by Pigmentiphaga sp. NDS-2. Uchihashi, K., Misawa, T., Takeo, M., Negoro, S. J. Biosci. Bioeng. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.