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Chemical Compound Review

C02202     (2R)-2-[[(2S)-2- (benzylamino)-3-phenyl...

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Disease relevance of C02202


High impact information on C02202

  • The pH optimum for cathepsin B (substrate: Z-Arg-Arg-HNMec) and L (substrate: Z-Phe-Arg-HNMec in the presence of Z-Phe-Phe-CHN2) was approximately pH 6.0 for both glomeruli and renal cortex; while that for cathepsin H (substrate: Arg-HNMec) was approximately 6 [4].
  • Under identical conditions Z-Phe-Phe-CHN2 (0.56 microM) completely inhibits cathepsin L but has little effect on cathepsin B. Incubation of glomerular basement membrane (GBM) with purified human kidney cathepsin L resulted in dose-dependent (10-40 nM) GBM degradation [5].
  • Cathepsin L exhibited a single band of Mr 27,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions, presented a high affinity for the substrate Z-Phe-Arg-NMec, was very unstable at neutral pH, and was inhibited by Z-Phe-Phe-CHN2 [6].
  • The stability of cathepsin S at pH 7.5 and the resistance of cathepsin B against inactivation by 0.5 microM Z-Phe-Phe-CHN2 permitted differentiation of these enzyme activities [7].
  • Kapp, the second-order rate constant of enzyme inactivation by Z-Phe-Phe-CHN2 with LE as substrate was 31,530 M-1 s-1 or 10(3) higher than its effect on cathepsin B-mediated hydrolysis of ME-Arg-Phe at the Met-Arg site [8].

Anatomical context of C02202

  • Culture for 5 days with thiol protease inhibitors such as leupeptin, E-64 or Z-Phe-Phe-CHN2 partially restored the beta-galactosidase activity of fibroblasts from patients, but did not affect the beta-galactosidase activity of fibroblasts from control subjects [9].

Gene context of C02202


  1. Progesterone-dependent cathepsin L proteolytic activity in cat uterine flushings. Li, W.G., Jaffe, R.C., Fazleabas, A.T., Verhage, H.G. Biol. Reprod. (1991) [Pubmed]
  2. Cathepsin B and L activities in isolated osteoclasts. Rifkin, B.R., Vernillo, A.T., Kleckner, A.P., Auszmann, J.M., Rosenberg, L.R., Zimmerman, M. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  3. Cathepsin B- and L-like activities at local gingival sites of chronic periodontitis patients. Eley, B.M., Cox, S.W. Journal of clinical periodontology. (1991) [Pubmed]
  4. Glomerular basement membrane degradation by endogenous cysteine proteinases in isolated rat glomeruli. Baricos, W.H., Cortez, S.L., Le, Q.C., Zhou, Y.W., Dicarlo, R.M., O'Connor, S.E., Shah, S.V. Kidney Int. (1990) [Pubmed]
  5. Human kidney cathepsins B and L. Characterization and potential role in degradation of glomerular basement membrane. Baricos, W.H., Zhou, Y., Mason, R.W., Barrett, A.J. Biochem. J. (1988) [Pubmed]
  6. Purification and amino acid sequence of chicken liver cathepsin L. Dufour, E., Obled, A., Valin, C., Béchet, D., Ribadeau-Dumas, B., Huet, J.C. Biochemistry (1987) [Pubmed]
  7. Specific catalytic activity of cathepsin S in comparison to cathepsins B and L along the rat nephron. Schmid, H., Koop, M., Utermann, S., Lambacher, L., Mayer, P., Schaefer, L. Biol. Chem. (1997) [Pubmed]
  8. Rat brain cathepsin L: characterization and differentiation from cathepsin B utilizing opioid peptides. Marks, N., Berg, M.J. Arch. Biochem. Biophys. (1987) [Pubmed]
  9. Involvement of thiol proteases in galactosialidosis. Takeda, E., Kuroda, Y., Toshima, K., Naito, E., Ito, M., Miyao, M., Kominami, E., Katunuma, N. Clin. Chim. Acta (1986) [Pubmed]
  10. Purification and properties of different isoforms of bovine cathepsin B. Deval, C., Bechet, D., Obled, A., Ferrara, M. Biochem. Cell Biol. (1990) [Pubmed]
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