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Chemical Compound Review

SureCN166576     1,3-thiazole-4-carboxamide

Synonyms: ACMC-1CQP1, AG-B-76921, ANW-13839, WTI-10222, AC1L9HPR, ...
 
 
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Disease relevance of thiazole-4-carboxamide

  • Incubation of tumour specimens obtained from paediatric patients with grade-IV neuroblastoma with TR resulted in the formation of the active metabolite, thiazole-4-carboxamide adenine dinucleotide, in concentrations sufficient to inhibit tumour growth [1].
  • Zeria and Yamanouchi are co-developing Z-338, a thiazole-4-carboxamide derivative with prokinetic activities, as a potential treatment for dyspepsia and gastric motility disorders [2].
 

High impact information on thiazole-4-carboxamide

References

  1. Cytotoxicity, differentiating activity and metabolism of tiazofurin in human neuroblastoma cells. Pillwein, K., Schuchter, K., Ressmańn, G., Gharehbaghi, K., Knoflach, A., Cermak, B., Jayaram, H.N., Szalay, S.M., Szekeres, T., Chiba, P. Int. J. Cancer (1993) [Pubmed]
  2. Z-338. Zeria/Yamanouchi. Lehmann, A. Current opinion in investigational drugs (London, England : 2000) (2004) [Pubmed]
  3. Tiazofurin metabolism in human lymphoblastoid cells: evidence for phosphorylation by adenosine kinase and 5'-nucleotidase. Fridland, A., Connelly, M.C., Robbins, T.J. Cancer Res. (1986) [Pubmed]
  4. Dehydrogenase binding by tiazofurin anabolites. Goldstein, B.M., Bell, J.E., Marquez, V.E. J. Med. Chem. (1990) [Pubmed]
  5. Synthesis of thiazole-4-carboxamide adenine dinucleotide. A powerful inhibitor of IMP dehydrogenase. Gebeyehu, G., Marquez, V.E., Kelley, J.A., Cooney, D.A., Jayaram, H.N., Johns, D.G. J. Med. Chem. (1983) [Pubmed]
  6. Determination of thiazole-4-carboxamide adenine dinucleotide (TAD) levels in mononuclear cells of leukemic patients treated with tiazofurin. Zhen, W., Jayaram, H.N., Weber, G. Biochem. Pharmacol. (1991) [Pubmed]
  7. Unique bioactivation of tiazofurin--studies with resistant cells. Kuttan, R. Indian J. Biochem. Biophys. (1989) [Pubmed]
 
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