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Chemical Compound Review

Phosmidosine     (2S)-N-[[(2R,3S,4R,5R)-5-(6- amino-8-oxo-7H...

Synonyms: SureCN4346112, AC1L9V1N, 134966-01-1
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Disease relevance of AIDS-008558

  • A new nucleotide antibiotic, phosmidosine was isolated from a culture filtrate of a newly isolated streptomycete identified as Streptomyces sp. RK-16 [1].

High impact information on AIDS-008558

  • Inhibition of cyclin D1 expression and phosphorylation of retinoblastoma protein by phosmidosine, a nucleotide antibiotic [2].
  • In serum-stimulated cells, phosmidosine did not affect the activation of the mitogen-activated protein kinase cascade [2].
  • Furthermore, in tsFT210 cells, a temperature-sensitive cdc2 mutant isolated from the mouse mammary carcinoma cell line FM3A, phosmidosine, irreversibly inhibited the cell cycle progression at G1 without affecting the G2 to M transition [2].
  • In this report, we studied the effect of phosmidosine, a proline-containing nucleotide on the serum-induced cell cycle progression in human lung fibroblast WI-38 cells [2].
  • Taken together, phosmidosine arrested cells at a specific point between the start point and restriction point in G1 and is a useful drug that may contribute to the understanding of the regulatory mechanisms of G1 progression [2].

Biological context of AIDS-008558


Anatomical context of AIDS-008558


Associations of AIDS-008558 with other chemical compounds


Gene context of AIDS-008558


  1. Isolation and characterization of phosmidosine. A new antifungal nucleotide antibiotic. Uramoto, M., Kim, C.J., Shin-Ya, K., Kusakabe, H., Isono, K., Phillips, D.R., McCloskey, J.A. J. Antibiot. (1991) [Pubmed]
  2. Inhibition of cyclin D1 expression and phosphorylation of retinoblastoma protein by phosmidosine, a nucleotide antibiotic. Kakeya, H., Onose, R., Liu, P.C., Onozawa, C., Matsumura, F., Osada, H. Cancer Res. (1998) [Pubmed]
  3. Synthesis of chemically stabilized phosmidosine analogues and the structure--activity relationship of phosmidosine. Sekine, M., Okada, K., Seio, K., Kakeya, H., Osada, H., Obata, T., Sasaki, T. J. Org. Chem. (2004) [Pubmed]
  4. First synthesis and anticancer activity of phosmidosine and its related compounds. Moriguchi, T., Asai, N., Okada, K., Seio, K., Sasaki, T., Sekine, M. J. Org. Chem. (2002) [Pubmed]
  5. Development and application of bioprobes for Mammalian cell cycle analyses. Osada, H. Current medicinal chemistry. (2003) [Pubmed]
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