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Chemical Compound Review:

Benedorm 3,3-diethyl-1H-pyridine-2,4- dione

Synonyms: Persedon, Persidon, Presidon, Prezidon, Pyridion, ...

Belcheva, I. et al., Balogh, A. et al., Ibáñez, L. et al., Dimov, S. et al., Beltcheva, I. et al., et al.

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Disease relevance of NU 903

In addition, in order to estimate the risk of pyrithyldione-associated agranulocytosis through a case-population approach, its consumption among the cases was compared with its consumption among the general population [1].
Toxicological studies on the acute and subchronic toxicity of two new derivatives of 3,3-diethyl-2,4-pyridinedione [2].
Anticonvulsant properties of two new 3,3-diethyl-2,4-pyridinedione derivatives. I. Effects in two experimental models of generalized epilepsy in cats [3].
Anticonvulsant properties of two new 3,3-diethyl-2,4-pyridinedione derivatives. II. Effects on two experimental models of cortical focal epilepsy in cats [4].
The anticonvulsant properties of two N-aminomethyl derivatives of 3,3-diethyl-2,4-pyridinedione (persedon) are studied on two experimental models of generalized (pentylenetetrazol and penicillin) epilepsy in cats [3].

High impact information on NU 903

In comparison to haemodialysis the efficacy of ultrafiltration by CSU was poor, as the mean per cent of CSU/haemodialysis (mg/hr) for 5 benzodiazepines was only 0.6-4.0% and for three hypnotics, phenobarbital 3.4%, pyrithyldione 8.2% and glutethimide 2.5% of the haemodialysis values [5].
Neuropharmacological screening of five 1-alkyl derivatives of 3,3-diethyl-2,4-pyridinedione was performed on male albino mice [6].

References

Agranulocytosis induced by pyrithyldione, a sedative hypnotic drug. Ibáñez, L., Ballarín, E., Pérez, E., Vidal, X., Capellà, D., Laporte, J.R. Eur. J. Clin. Pharmacol. (2000) [Pubmed]
Toxicological studies on the acute and subchronic toxicity of two new derivatives of 3,3-diethyl-2,4-pyridinedione. Belcheva, I., Stoytchev, T. Acta physiologica et pharmacologica Bulgarica. (1984) [Pubmed]
Anticonvulsant properties of two new 3,3-diethyl-2,4-pyridinedione derivatives. I. Effects in two experimental models of generalized epilepsy in cats. Belcheva, I., Dimov, S., Stoychev, T. Acta physiologica et pharmacologica Bulgarica. (1981) [Pubmed]
Anticonvulsant properties of two new 3,3-diethyl-2,4-pyridinedione derivatives. II. Effects on two experimental models of cortical focal epilepsy in cats. Dimov, S., Belcheva, I. Acta physiologica et pharmacologica Bulgarica. (1981) [Pubmed]
Dialysability of benzodiazepines by haemodialysis and controlled sequential ultrafiltration (CSU) in vitro. Balogh, A., Fünfstück, R., Demme, U., Kangas, L., Sperschneider, H., Traeger, A., Stein, G., Pekkarinen, A. Acta pharmacologica et toxicologica. (1981) [Pubmed]
Neuropharmacological activity of new derivatives of 3,3-diethyl-2,4-pyridinedione. IV. 1-alkyl derivatives of 3,3-diethyl-2,4-pyridinedione. Beltcheva, I., Stoytchev, T., Danchev, D., Karadjov, K. Acta physiologica et pharmacologica Bulgarica. (1979) [Pubmed]

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