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Chemical Compound Review

Doriden     3-ethyl-3-phenyl-piperidine- 2,6-dione

Synonyms: Dorimide, Elrodorm, Alfimid, Noxiron, Noxyron, ...
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Disease relevance of glutethimide

  • Column hemoperfusion with Amberlite XAD-4 resin was simpler and more effective than any known method of removing barbiturates and glutethimide from the blood of patients with drug overdoses [1].
  • The authors describes a patient who presented catatonialike symptoms and dyskinesias associated with glutethimide discontinuance and antihistamine use [2].
  • Severe hypocalcemia associated with chronic glutethimide addiction: a case report [3].
  • The present case also indicates that, in the absence of cerebral ischemia or hypoxemia secondary to cardiopulmonary depression, complete clinical recovery from glutethimide-induced coma is possible no matter how severe the presenting neurologic and EEG signs [4].
  • Controlled trials of glutethimide to compare its efficacy with that of other medications used in the treatment of action tremor are indicated [5].

Psychiatry related information on glutethimide


High impact information on glutethimide


Chemical compound and disease context of glutethimide


Biological context of glutethimide


Anatomical context of glutethimide


Associations of glutethimide with other chemical compounds


Gene context of glutethimide


Analytical, diagnostic and therapeutic context of glutethimide

  • After ingestion of 75 gm of glutethimide, one patient received hemoperfusion on three successive days for nine, ten, and eight hours, respectively [1].
  • The cyclic and, sometimes, unilateral nature of the clinical findings previously reported in glutethimide coma was confirmed and seen to be reflected in the EEG [4].
  • Enantioseparation of glutethimide and its 5-OH-metabolite in capillary electrophoresis and study of selector-selectand interactions using one-dimensional rotating frame nuclear Overhauser and exchange spectroscopy [35].
  • Glutethimide interfered with radioimmunoassay of barbiturate, producing false positives [36].
  • 3 A 'modified' form of the 2 h breath test calculated from the area under the breath specific activity curve detected the increase in demethylation following glutethimide [37].


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  2. Catatonialike symptomatology and withdrawal dyskinesias. Good, M.I. The American journal of psychiatry. (1976) [Pubmed]
  3. Severe hypocalcemia associated with chronic glutethimide addiction: a case report. Ober, K.P., Hennessy, J.F., Hellman, R.M. The American journal of psychiatry. (1981) [Pubmed]
  4. Neurologic and electroencephalographic correlates in glutethimide intoxication. Myers, R.R., Stockard, J.J. Clin. Pharmacol. Ther. (1975) [Pubmed]
  5. Glutethimide treatment of disabling action tremor in patients with multiple sclerosis and traumatic brain injury. Aisen, M.L., Holzer, M., Rosen, M., Dietz, M., McDowell, F. Arch. Neurol. (1991) [Pubmed]
  6. Catatonia associated with glutethimide withdrawal. Campbell, R., Schaffer, C.B., Tupin, J. The Journal of clinical psychiatry. (1983) [Pubmed]
  7. Antiandrogen withdrawal syndrome associated with prostate cancer therapies: incidence and clinical significance. Paul, R., Breul, J. Drug safety : an international journal of medical toxicology and drug experience. (2000) [Pubmed]
  8. Blood concentrations and clinical findings in nonfatal and fatal intoxications involving glutethimide and codeine. Bailey, D.N., Shaw, R.F. J. Toxicol. Clin. Toxicol. (1985) [Pubmed]
  9. Neonatal withdrawal symptoms associated with glutethimide (Doriden) addiction in the mother during pregnancy. Reveri, M., Pyati, S.P., Pildes, R.S. Clinical pediatrics. (1977) [Pubmed]
  10. Letter: Activity of glutethimide metabolite in human beings. Gold, M., Tassoni, E.M., Etzi, M.M., Mathew, G. N. Engl. J. Med. (1975) [Pubmed]
  11. Repression of hepatic delta-aminolevulinate synthase by heme and metalloporphyrins: relationship to inhibition of heme oxygenase. Cable, E.E., Cable, J.W., Bonkovsky, H.L. Hepatology (1993) [Pubmed]
  12. Glutethimide and 4-OH glutethimide: pharmacokinetics and effect on performance in man. Crow, J.W., Lain, P., Bochner, F., Shoeman, D.W., Azarnoff, D.L. Clin. Pharmacol. Ther. (1977) [Pubmed]
  13. Excretion of psychoactive drugs into breast milk. Pharmacokinetic principles and recommendations. Pons, G., Rey, E., Matheson, I. Clinical pharmacokinetics. (1994) [Pubmed]
  14. Immunochemical studies of haem oxygenase. Preparation and characterization of antibodies to chick liver haem oxygenase and their use in detecting and quantifying amounts of haem oxygenase protein. Greene, Y.J., Healey, J.F., Bonkovsky, H.L. Biochem. J. (1991) [Pubmed]
  15. Interpretation of blood glutethimide, meprobamate, and methyprylon concentrations in nonfatal and fatal intoxications involving a single drug. Bailey, D.N., Shaw, R.F. J. Toxicol. Clin. Toxicol. (1983) [Pubmed]
  16. Enhancement of hepatic drug metabolism by glutethimide in patients with liver disease. Farrell, G.C., Cooksley, W.G., Powell, L.W. Eur. J. Clin. Pharmacol. (1979) [Pubmed]
  17. Toxicity of alpha-phenyl-gamma-butyrolactone, a metabolite of glutethimide in human urine. Andresen, B.D., Davis, F.T., Templeton, J.L., Panzik, H.L., Hammer, R.H. Res. Commun. Chem. Pathol. Pharmacol. (1977) [Pubmed]
  18. Recent developments in the study of the effects of cigarette smoking on clinical pharmacokinetics and clinical pharmacodynamics. Miller, L.G. Clinical pharmacokinetics. (1989) [Pubmed]
  19. Descriptive epidemiology of mortality in New Jersey due to combinations of codeine and glutethimide. Feuer, E., French, J. Am. J. Epidemiol. (1984) [Pubmed]
  20. The features of hepatic enzyme induction with glutethimide in man. Jackson, L., Homeida, M., Roberts, C.J. British journal of clinical pharmacology. (1978) [Pubmed]
  21. Investigation of the stereoselective in vitro biotransformation of glutethimide by high-performance liquid chromatography and capillary electrophoresis. Weinz, C., Blaschke, G., Schiebel, H.M. J. Chromatogr. B Biomed. Sci. Appl. (1997) [Pubmed]
  22. Immunochemical detection of different isoenzymes of cytochrome P-450 induced in chick hepatocyte cultures. Sinclair, P., Frezza, J., Sinclair, J., Bement, W., Haugen, S., Healey, J., Bonkovsky, H. Biochem. J. (1989) [Pubmed]
  23. Uptake in vitro of lipophilic model compounds into adipose tissue preparations and lipids. Di Francesco, C., Bickel, M.H. Biochem. Pharmacol. (1985) [Pubmed]
  24. Identification and synthesis of a methylated catechol metabolite of glutethimide isolated from biological fluids of overdose victims. Andresen, B.D., Davis, F.T., Long, M.D. Journal of pharmaceutical sciences. (1979) [Pubmed]
  25. Brain mitochondrial cytochrome P-450scc: spectral and catalytic properties. Walther, B., Ghersi-Egea, J.F., Minn, A., Siest, G. Arch. Biochem. Biophys. (1987) [Pubmed]
  26. Comparison of the form(s) of cytochrome P-450 induced by ethanol and glutethimide in cultured chick hepatocytes. Sinclair, J.F., Wood, S.G., Smith, E.L., Sinclair, P.R., Koop, D.R. Biochem. Pharmacol. (1989) [Pubmed]
  27. 3,5,5-Trimethylhexanoylferrocene induction of heme oxygenase activity in normal hepatocytes. Lambrecht, R.W., Cable, J.W., Pepe, J.A., Bonkovsky, H.L. Biochem. Pharmacol. (1994) [Pubmed]
  28. Mechanism of synergistic induction of hepatic heme oxygenase by glutethimide and iron: studies in cultured chick embryo liver cells. Cable, E., Greene, Y., Healey, J., Evans, C.O., Bonkovsky, H. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  29. Double-blind evaluation of the efficacy and safety of temazepam in outpatients with insomnia. Fillingim, J.M. British journal of clinical pharmacology. (1979) [Pubmed]
  30. Simultaneous determination of glutethimide, methyprylon, and methaqualone in serum by gas liquid chromatography. Anweiler, J., Bender, G., Höbel, M. Arch. Toxicol. (1976) [Pubmed]
  31. Developmental regulation of the 3-methylcholanthrene- and dioxin-inducible CYP1A5 gene in chick embryo liver in vivo. Bentivegna, C.S., Ihnat, M.A., Baptiste, N.S., Hamilton, J.W. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  32. Preferential alteration of inducible gene expression in vivo by carcinogens that induce bulky DNA lesions. Hamilton, J.W., Louis, C.A., Doherty, K.A., Hunt, S.R., Reed, M.J., Treadwell, M.D. Mol. Carcinog. (1993) [Pubmed]
  33. Expression of 5-aminolaevulinate synthase and cytochrome P-450 mRNAs in chicken embryo hepatocytes in vivo and in culture. Effect of porphyrinogenic drugs and haem. Hamilton, J.W., Bement, W.J., Sinclair, P.R., Sinclair, J.F., Wetterhahn, K.E. Biochem. J. (1988) [Pubmed]
  34. Synergistic induction of delta-aminolevulinate synthase by glutethimide and iron: relationship to the synergistic induction of heme oxygenase. Cable, E.E., Healey, J.F., Greene, Y., Evans, C.O., Bonkovsky, H.L. Biochim. Biophys. Acta (1991) [Pubmed]
  35. Enantioseparation of glutethimide and its 5-OH-metabolite in capillary electrophoresis and study of selector-selectand interactions using one-dimensional rotating frame nuclear Overhauser and exchange spectroscopy. Chankvetadze, B., Burjanadze, N., Bergander, K., Blaschke, G. Electrophoresis (2002) [Pubmed]
  36. Comparison of radioimmunoassay with thin-layer chromatographic and gas-liquid chromatographic methods of barbiturate detection in human urine. Roerig, D.L., Lewand, D.L., Mueller, M.A., Wang, R.I. Clin. Chem. (1975) [Pubmed]
  37. The [14C]-aminopyrine breath test. A comparison of different forms of analysis. Henry, D.A., Sharpe, G., Chaplain, S., Cartwright, S., Kitchingman, G., Bell, G.D., Langman, M.J. British journal of clinical pharmacology. (1979) [Pubmed]
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