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Chemical Compound Review

amacetam     N-[2-(dipropan-2- ylamino)ethyl]-2-(2...

Synonyms: pramiracetam, Pramiracetamum, CHEMBL159776, SureCN195465, AG-G-63706, ...
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Disease relevance of pramiracetam

  • The action of pramiracetam on consequences of hypobaric hypoxia is only moderate [1].
  • The current study evaluated under double-blind placebo-controlled conditions, the safety and efficacy of 400 mg pramiracetam sulphate TID in treating memory and other cognitive problems of males who have sustained brain injuries [2].

Psychiatry related information on pramiracetam


High impact information on pramiracetam


Chemical compound and disease context of pramiracetam


Analytical, diagnostic and therapeutic context of pramiracetam

  • The cognitive-enhancing effects of pramiracetam in animal models of learning and memory are characterized by an inverted U-shaped dose-response curve [3].
  • The plasma profile of pramiracetam proved to be not highly affected by the formulation, only that the absorption rate was faster after oral administration of the drug in solution than after administration as a tablet [9].
  • Pharmacologic therapeutic window of pramiracetam demonstrated in behavior, EEG, and single neuron firing rates [10].


  1. The action of pramiracetam on consequences of hypobaric hypoxia is only moderate. Maresová, D., Mares, P. Physiological research / Academia Scientiarum Bohemoslovaca. (1996) [Pubmed]
  2. Placebo-controlled study of pramiracetam in young males with memory and cognitive problems resulting from head injury and anoxia. McLean, A., Cardenas, D.D., Burgess, D., Gamzu, E. Brain injury : [BI]. (1991) [Pubmed]
  3. Nootropic drugs in Alzheimer's disease: symptomatic treatment with pramiracetam. Claus, J.J., Ludwig, C., Mohr, E., Giuffra, M., Blin, J., Chase, T.N. Neurology (1991) [Pubmed]
  4. The effects of cholinergic drugs support an avoidance learning hypothesis of brief footshock-induced analgesia. Gower, A.J., Tricklebank, M.D. Neuropharmacology (1986) [Pubmed]
  5. Pramiracetam effects on scopolamine-induced amnesia in healthy volunteers. Mauri, M., Sinforiani, E., Reverberi, F., Merlo, P., Bono, G. Archives of gerontology and geriatrics. (1994) [Pubmed]
  6. Clinical pharmacokinetics of drugs for Alzheimer's disease. Parnetti, L. Clinical pharmacokinetics. (1995) [Pubmed]
  7. Pharmacokinetics of oral pramiracetam in normal volunteers. Chang, T., Young, R.M., Goulet, J.R., Yakatan, G.J. Journal of clinical pharmacology. (1985) [Pubmed]
  8. Systemic administration of pramiracetam increases nitric oxide synthase activity in the cerebral cortex of the rat. Corasaniti, M.T., Paoletti, A.M., Palma, E., Granato, T., Navarra, M., Nisticò, G. Funct. Neurol. (1995) [Pubmed]
  9. Pharmacokinetics of pramiracetam in healthy volunteers after oral administration. Auteri, A., Blardi, P., Celasco, G., Segre, G., Urso, R. International journal of clinical pharmacology research. (1992) [Pubmed]
  10. Pharmacologic therapeutic window of pramiracetam demonstrated in behavior, EEG, and single neuron firing rates. Poschel, B.P., Ho, P.M., Ninteman, F.W., Callahan, M.J. Experientia (1985) [Pubmed]
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