Disease relevance of pramiracetam

• The action of pramiracetam on consequences of hypobaric hypoxia is only moderate [1].
• The current study evaluated under double-blind placebo-controlled conditions, the safety and efficacy of 400 mg pramiracetam sulphate TID in treating memory and other cognitive problems of males who have sustained brain injuries [2].

Psychiatry related information on pramiracetam

• Nootropic drugs in Alzheimer's disease: symptomatic treatment with pramiracetam [3].
• Drugs known to improve memory, including physostigmine, pramiracetam and the muscarinic agonists, oxotremorine and RS 86, selectively induced analgesia in rats subjected to test before the shock plus the shock, thereby supporting a hypothesis of avoidance learning [4].
• Pramiracetam effects on scopolamine-induced amnesia in healthy volunteers [5].

High impact information on pramiracetam

• However, of the 3 agents reviewed only pramiracetam penetrates the central nervous system (CNS) poorly [6].
• The pharmacokinetics of pramiracetam, a new, investigational, cognition activator, were assessed in normal male volunteers as part of a clinical tolerance study [7].
• Systemic administration of pramiracetam increases nitric oxide synthase activity in the cerebral cortex of the rat [8].

Chemical compound and disease context of pramiracetam

• The possible protective action of pramiracetam, a pyrrolidinone nootropic drug, against hypobaric hypoxia was studied in two age groups of immature rats with implanted electrodes [1].

Analytical, diagnostic and therapeutic context of pramiracetam

• The cognitive-enhancing effects of pramiracetam in animal models of learning and memory are characterized by an inverted U-shaped dose-response curve [3].
• The plasma profile of pramiracetam proved to be not highly affected by the formulation, only that the absorption rate was faster after oral administration of the drug in solution than after administration as a tablet [9].
• Pharmacologic therapeutic window of pramiracetam demonstrated in behavior, EEG, and single neuron firing rates [10].

References