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Chemical Compound Review

AC1NRBUB     benzylN-[(2S)-4-methyl-1- [(3R)-3-[[(2S)-4...

Synonyms:
 
 
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Disease relevance of PYRROLIDINONE

 

Psychiatry related information on PYRROLIDINONE

 

High impact information on PYRROLIDINONE

 

Chemical compound and disease context of PYRROLIDINONE

 

Biological context of PYRROLIDINONE

 

Anatomical context of PYRROLIDINONE

  • Additional metabolites isolated and identified by liquid chromatography-tandem mass spectrometry, and accounting for 1 to 5% of the excreted radioactivity in rat feces during the first 24 h, included two monohydroxylevormeloxifene species, a pyrrolidinone ring-opened metabolite of levormeloxifene, and desmethylnorlevormeloxifene [20].
  • We here investigated the effects of nebracetam (WEB 1881 FU 4-aminomethyl-1-benzylpyrrolidin-2-one-hemifumarate), a novel pyrrolidinone nootropic, on the rise of intracellular Ca2+ concentration ([Ca2+]i) in Jurkat cells, a human leukemic T cell line [21].
  • When the transport of PD was tested using the in situ brain perfusion technique, it was clarified that PD was not transported across the blood-brain barrier (BBB) by a neutral amino acid carrier system [22].
 

Associations of PYRROLIDINONE with other chemical compounds

  • METHODS: In vivo measurements of GABA, homocarnosine, and pyrrolidinone were made of a 14-cc volume in the occipital cortex using 1H spectroscopy with a 2.1-Tesla magnetic resonance spectrometer and an 8-cm surface coil [23].
  • In a double-blind, placebo-controlled, cross-over trial, the antihypoxidotic properties of BMS-181168 (previously BMY 21502)--a 1-[[1-[2-(trifluoromethyl)-4-pyrimidinyl]-4-piperidinyl]methyl]-2- pyrrolidinone alleviating impairment of learning and memory in the animal--were studied utilizing EEG mapping under an experimental hypoxic hypoxidosis [24].
  • A long DNA molecule was used to guide the assembly of pyrrolidinone-capped Fe2O3 and CoFe2O3 particles as well as polylysine-coated gold nanoparticles [25].
  • Three of five obtained analogues, pyrrolidinone, oxazolidinone and thiazolidinone demonstrated an interesting, specific odor which was compared with floral, typical jasmine odor of jasmone [26].
 

Gene context of PYRROLIDINONE

 

Analytical, diagnostic and therapeutic context of PYRROLIDINONE

References

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  11. In vitro activities of BAL9141, a novel broad-spectrum pyrrolidinone cephalosporin, against gram-negative nonfermenters. Zbinden, R., Pünter, V., von Graevenitz, A. Antimicrob. Agents Chemother. (2002) [Pubmed]
  12. Selected reaction monitoring LC-MS determination of idoxifene and its pyrrolidinone metabolite in human plasma using robotic high-throughput, sequential sample injection. Onorato, J.M., Henion, J.D., Lefebvre, P.M., Kiplinger, J.P. Anal. Chem. (2001) [Pubmed]
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  15. Occurrence of the nitrosamide precursor pyrrolidin-(2)-one in food and tobacco. Mende, P., Ziebarth, D., Preussmann, R., Spiegelhalder, B. Carcinogenesis (1994) [Pubmed]
  16. A 1-heteroaryl-4-piperidinyl-methyl pyrrolidinone, BMY 21502, delays the decay of hippocampal synaptic potentiation in vitro. Gribkoff, V.K., Bauman, L.A., VanderMaelen, C.P. Neuropharmacology (1990) [Pubmed]
  17. Phenotype of B cells responding to the thymus-independent type-2 antigen polyvinyl pyrrolidinone. Whitmore, A.C., Haughton, G., Arnold, L.W. Int. Immunol. (1996) [Pubmed]
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  19. A pyrrolidinone derivative inhibits cytokine-induced iNOS expression and NF-kappaB activation by preventing phosphorylation and degradation of IkappaB-alpha. Katsuyama, K., Hirata, Y. J. Biochem. (2001) [Pubmed]
  20. Metabolism, disposition, excretion, and pharmacokinetics of levormeloxifene, a selective estrogen receptor modulator, in the rat. Mountfield, R.J., Kiehr, B., John, B.A. Drug Metab. Dispos. (2000) [Pubmed]
  21. Effects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist. Kitamura, Y., Kaneda, T., Nomura, Y. Jpn. J. Pharmacol. (1991) [Pubmed]
  22. Pharmacokinetics of aniracetam and its metabolites in rat brain. Ogiso, T., Uchiyama, K., Suzuki, H., Yoshimoro, M., Tanino, T., Iwakai, M., Uno, S. Biol. Pharm. Bull. (2000) [Pubmed]
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  25. DNA-templated magnetic nanowires with different compositions: fabrication and analysis. Kinsella, J.M., Ivanisevic, A. Langmuir : the ACS journal of surfaces and colloids (2007) [Pubmed]
  26. Microwave assisted synthesis of fragrant jasmone heterocyclic analogues. Pawełczyk, A., Zaprutko, L. European journal of medicinal chemistry. (2006) [Pubmed]
  27. Design and synthesis of 2-oxo-imidazolidine-4-carboxylic acid hydroxyamides as potent matrix metalloproteinase-13 inhibitors. Robinson, R.P., Laird, E.R., Donahue, K.M., Lopresti-Morrow, L.L., Mitchell, P.G., Reese, M.R., Reeves, L.M., Rouch, A.I., Stam, E.J., Yocum, S.A. Bioorg. Med. Chem. Lett. (2001) [Pubmed]
  28. Structure-based design and synthesis of a potent matrix metalloproteinase-13 inhibitor based on a pyrrolidinone scaffold. Robinson, R.P., Laird, E.R., Blake, J.F., Bordner, J., Donahue, K.M., Lopresti-Morrow, L.L., Mitchell, P.G., Reese, M.R., Reeves, L.M., Stam, E.J., Yocum, S.A. J. Med. Chem. (2000) [Pubmed]
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