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Chemical Compound Review

AC1NRBUB     benzylN-[(2S)-4-methyl-1- [(3R)-3-[[(2S)-4...

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Disease relevance of PYRROLIDINONE


Psychiatry related information on PYRROLIDINONE


High impact information on PYRROLIDINONE


Chemical compound and disease context of PYRROLIDINONE


Biological context of PYRROLIDINONE


Anatomical context of PYRROLIDINONE

  • Additional metabolites isolated and identified by liquid chromatography-tandem mass spectrometry, and accounting for 1 to 5% of the excreted radioactivity in rat feces during the first 24 h, included two monohydroxylevormeloxifene species, a pyrrolidinone ring-opened metabolite of levormeloxifene, and desmethylnorlevormeloxifene [20].
  • We here investigated the effects of nebracetam (WEB 1881 FU 4-aminomethyl-1-benzylpyrrolidin-2-one-hemifumarate), a novel pyrrolidinone nootropic, on the rise of intracellular Ca2+ concentration ([Ca2+]i) in Jurkat cells, a human leukemic T cell line [21].
  • When the transport of PD was tested using the in situ brain perfusion technique, it was clarified that PD was not transported across the blood-brain barrier (BBB) by a neutral amino acid carrier system [22].

Associations of PYRROLIDINONE with other chemical compounds

  • METHODS: In vivo measurements of GABA, homocarnosine, and pyrrolidinone were made of a 14-cc volume in the occipital cortex using 1H spectroscopy with a 2.1-Tesla magnetic resonance spectrometer and an 8-cm surface coil [23].
  • In a double-blind, placebo-controlled, cross-over trial, the antihypoxidotic properties of BMS-181168 (previously BMY 21502)--a 1-[[1-[2-(trifluoromethyl)-4-pyrimidinyl]-4-piperidinyl]methyl]-2- pyrrolidinone alleviating impairment of learning and memory in the animal--were studied utilizing EEG mapping under an experimental hypoxic hypoxidosis [24].
  • A long DNA molecule was used to guide the assembly of pyrrolidinone-capped Fe2O3 and CoFe2O3 particles as well as polylysine-coated gold nanoparticles [25].
  • Three of five obtained analogues, pyrrolidinone, oxazolidinone and thiazolidinone demonstrated an interesting, specific odor which was compared with floral, typical jasmine odor of jasmone [26].

Gene context of PYRROLIDINONE


Analytical, diagnostic and therapeutic context of PYRROLIDINONE


  1. BAL 9141, a new broad-spectrum pyrrolidinone cephalosporin: activity against clinically significant anaerobes in comparison with 10 other antimicrobials. Wootton, M., Bowker, K.E., Holt, H.A., MacGowan, A.P. J. Antimicrob. Chemother. (2002) [Pubmed]
  2. Blockade of nuclear factor-kappaB activation prevents hypodynamic shock and gastric hypoperfusion induced by endotoxin in anesthetized dogs. Mitaka, C., Hirata, Y., Narumi, Y., Yokoyama, K., Makita, K., Katsuyama, K., Imai, T. Intensive care medicine. (2005) [Pubmed]
  3. Optimization of pyrrolidinone based HIV protease inhibitors. Sherrill, R.G., Andrews, C.W., Bock, W.J., Davis-Ward, R.G., Furfine, E.S., Hazen, R.J., Rutkowske, R.D., Spaltenstein, A., Wright, L.L. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  4. Effects of BMY-21502 on anoxia in mice. Amano, M., Goto, A., Takahashi, N., Hasegawa, T., Nabeshima, T. Jpn. J. Pharmacol. (1993) [Pubmed]
  5. Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: modifications of essential pyrrolidinone ring substituents. Brouillette, W.J., Bajpai, S.N., Ali, S.M., Velu, S.E., Atigadda, V.R., Lommer, B.S., Finley, J.B., Luo, M., Air, G.M. Bioorg. Med. Chem. (2003) [Pubmed]
  6. Stereoselective synthesis of constrained azacyclic hydroxyethylene isosteres as aspartic protease inhibitors: dipolar cycloaddition and related methodologies toward branched pyrrolidine and pyrrolidinone carboxylic acids. Hanessian, S., Yun, H., Hou, Y., Tintelnot-Blomley, M. J. Org. Chem. (2005) [Pubmed]
  7. Effect of BMY 21502 on acquisition of shape discrimination and memory retention in monkey. Fitten, L.J., Perryman, K.M., Hanna, J.A., Menon, M.K. Pharmacol. Biochem. Behav. (1990) [Pubmed]
  8. Rapid induction of splenic and peritoneal B-1a cells in adult mice by thymus-independent type-2 antigen. Whitmore, A.C., Neely, H.R., Diz, R., Flood, P.M. J. Immunol. (2004) [Pubmed]
  9. Synthesis of ent-alantrypinone. Hart, D.J., Magomedov, N.A. J. Am. Chem. Soc. (2001) [Pubmed]
  10. Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy. Petroff, O.A., Hyder, F., Mattson, R.H., Rothman, D.L. Neurology (1999) [Pubmed]
  11. In vitro activities of BAL9141, a novel broad-spectrum pyrrolidinone cephalosporin, against gram-negative nonfermenters. Zbinden, R., Pünter, V., von Graevenitz, A. Antimicrob. Agents Chemother. (2002) [Pubmed]
  12. Selected reaction monitoring LC-MS determination of idoxifene and its pyrrolidinone metabolite in human plasma using robotic high-throughput, sequential sample injection. Onorato, J.M., Henion, J.D., Lefebvre, P.M., Kiplinger, J.P. Anal. Chem. (2001) [Pubmed]
  13. Nootropic drugs and brain cholinergic mechanisms. Pepeu, G., Spignoli, G. Prog. Neuropsychopharmacol. Biol. Psychiatry (1989) [Pubmed]
  14. Aniracetam reverses memory impairment in rats. Martin, J.R., Moreau, J.L., Jenck, F. Pharmacol. Res. (1995) [Pubmed]
  15. Occurrence of the nitrosamide precursor pyrrolidin-(2)-one in food and tobacco. Mende, P., Ziebarth, D., Preussmann, R., Spiegelhalder, B. Carcinogenesis (1994) [Pubmed]
  16. A 1-heteroaryl-4-piperidinyl-methyl pyrrolidinone, BMY 21502, delays the decay of hippocampal synaptic potentiation in vitro. Gribkoff, V.K., Bauman, L.A., VanderMaelen, C.P. Neuropharmacology (1990) [Pubmed]
  17. Phenotype of B cells responding to the thymus-independent type-2 antigen polyvinyl pyrrolidinone. Whitmore, A.C., Haughton, G., Arnold, L.W. Int. Immunol. (1996) [Pubmed]
  18. Biotransformation of a new pyrrolidinone cognition-enhancing agent: isolation and identification of metabolites in human urine. Fujimaki, Y., Hashimoto, K., Sudo, K., Tachizawa, H. Xenobiotica (1990) [Pubmed]
  19. A pyrrolidinone derivative inhibits cytokine-induced iNOS expression and NF-kappaB activation by preventing phosphorylation and degradation of IkappaB-alpha. Katsuyama, K., Hirata, Y. J. Biochem. (2001) [Pubmed]
  20. Metabolism, disposition, excretion, and pharmacokinetics of levormeloxifene, a selective estrogen receptor modulator, in the rat. Mountfield, R.J., Kiehr, B., John, B.A. Drug Metab. Dispos. (2000) [Pubmed]
  21. Effects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist. Kitamura, Y., Kaneda, T., Nomura, Y. Jpn. J. Pharmacol. (1991) [Pubmed]
  22. Pharmacokinetics of aniracetam and its metabolites in rat brain. Ogiso, T., Uchiyama, K., Suzuki, H., Yoshimoro, M., Tanino, T., Iwakai, M., Uno, S. Biol. Pharm. Bull. (2000) [Pubmed]
  23. Topiramate rapidly raises brain GABA in epilepsy patients. Petroff, O.A., Hyder, F., Rothman, D.L., Mattson, R.H. Epilepsia (2001) [Pubmed]
  24. BMS-181168 for protection of the human brain against hypoxia: double-blind, placebo-controlled EEG mapping studies. Saletu, B., Schulz, H., Herrmann, W.M., Anderer, P., Shrotriya, R.C., Vanbrabant, E. Pharmacopsychiatry (1994) [Pubmed]
  25. DNA-templated magnetic nanowires with different compositions: fabrication and analysis. Kinsella, J.M., Ivanisevic, A. Langmuir : the ACS journal of surfaces and colloids (2007) [Pubmed]
  26. Microwave assisted synthesis of fragrant jasmone heterocyclic analogues. Pawełczyk, A., Zaprutko, L. European journal of medicinal chemistry. (2006) [Pubmed]
  27. Design and synthesis of 2-oxo-imidazolidine-4-carboxylic acid hydroxyamides as potent matrix metalloproteinase-13 inhibitors. Robinson, R.P., Laird, E.R., Donahue, K.M., Lopresti-Morrow, L.L., Mitchell, P.G., Reese, M.R., Reeves, L.M., Rouch, A.I., Stam, E.J., Yocum, S.A. Bioorg. Med. Chem. Lett. (2001) [Pubmed]
  28. Structure-based design and synthesis of a potent matrix metalloproteinase-13 inhibitor based on a pyrrolidinone scaffold. Robinson, R.P., Laird, E.R., Blake, J.F., Bordner, J., Donahue, K.M., Lopresti-Morrow, L.L., Mitchell, P.G., Reese, M.R., Reeves, L.M., Stam, E.J., Yocum, S.A. J. Med. Chem. (2000) [Pubmed]
  29. Pharmacokinetics of aniracetam and its metabolites in rats. Ogiso, T., Iwaki, M., Tanino, T., Ikeda, K., Paku, T., Horibe, Y., Suzuki, H. Journal of pharmaceutical sciences. (1998) [Pubmed]
  30. Determination of pyrrolidinone in plasma by high-performance liquid chromatography. Dell, D., Wendt, G., Bucheli, F., Trautmann, K.H. J. Chromatogr. (1985) [Pubmed]
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