Disease relevance of Seconal sodium

• In non-pretreated animals, D and S induced immobility, impairment of coordination and hypothermia in a dose-dependent manner [1].

High impact information on Seconal sodium

• 4. Whole-cell ATP-K+ currents were used to quantify the effects of the barbiturates: concentration-inhibition curves for thiopentone, secobarbitone and pentobarbitone resulted in IC50 values of 62, 250 and 360 microM respectively [2].
• Immunoassays performed well when operating above their specified cut-off concentrations but, because they are directed to quinalbarbitone showed reduced cross-reactivity with amylobarbitone, the barbiturate more commonly prescribed in the UK [3].
• After Seconal anesthesia, the hindquarters of diabetic and control rats were perfused at a constant flow rate per 100 g through the abdominal aorta with oxygenated Tyrode solution containing dextran [4].
• The inducing effect of certain barbiturates (secobarbitone, thiopentone, pentobarbitone, allobarbitone, phenobarbitone and barbitone) on the levels of the hepatic microsomal drug-metabolizing enzymes has been studied in the rat both in vivo and in vitro [5].
• Proceedings: A quantitative investigation into the effects of carbamazepine, diazepan and quinalbarbitone on the EEG and visual evoked potential in man [6].

Analytical, diagnostic and therapeutic context of Seconal sodium

• One day after this period the mice received an i.p. injection of one out of 16 drug combinations (crossover design: 0, 2, 4, 6 mg/kg D combined with 0, 6, 12, 18 mg/kg S) [1].

References