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Chemical Compound Review

AC1NRAZH     (2E,4E,6E,8E)-N-ethyl-3,7- dimethyl-9-(2,6...

Synonyms: CHEMBL418471, CCRIS 4283, CHEBI:191990, LS-143462, DB03917, ...
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High impact information on n-ethyl retinamide

  • Modification of sister chromatid exchanges and radiation-induced transformation in mouse C3H/10T 1/2 and Syrian hamster embryo cells by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and two retinoids, the trimethylmethoxyphenyl analog of N-ethyl retinamide and beta-all-trans-retinoic acid, has been studied [1].
  • The three-dimensional structure of bovine plasma retinol-binding protein (RBP) complexed with N-ethyl retinamide has been determined at 1.9-A resolution [2].
  • The failure of N-ethylretinamide and N-(2-hydroxyethyl)retinamide to inhibit the incidence or severity of bladder carcinoma in female Fischer rats initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide supports the concept that the inhibition of bladder carcinogenesis by natural and synthetic retinoids is carcinogen-class specific [3].
  • The incidence of abnormal fetuses, irrespective of the specific abnormalities induced, was markedly increased (50-100%) by TRA, ETR, ACIT, 13CRA and 4HPR, whereas TZR and NBR caused moderate increases (20-50%), and NER and 13CNER induced mild increases (10-20%) [4].
  • The germinal epithelium of the testicular tubules was completely atrophic in the groups fed ER and HER [5].

Anatomical context of n-ethyl retinamide


Gene context of n-ethyl retinamide


  1. Modification of sister chromatid exchanges and radiation-induced transformation in rodent cells by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and two retinoids. Miller, R.C., Geard, C.R., Osmak, R.S., Rutledge-Freeman, M., Ong, A., Mason, H., Napholz, A., Perez, N., Harisiadis, L., Borek, C. Cancer Res. (1981) [Pubmed]
  2. The interaction of N-ethyl retinamide with plasma retinol-binding protein (RBP) and the crystal structure of the retinoid-RBP complex at 1.9-A resolution. Zanotti, G., Malpeli, G., Berni, R. J. Biol. Chem. (1993) [Pubmed]
  3. Synthetic retinamides: effect on urinary bladder carcinogenesis by FANFT in Fischer rats. Croft, W.A., Croft, M.A., Paulus, K.P., Williams, J.H., Wang, C.Y., Lower, G.M. Carcinogenesis (1981) [Pubmed]
  4. Comparative teratogenicity of nine retinoids in the rat. Turton, J.A., Willars, G.B., Haselden, J.N., Ward, S.J., Steele, C.E., Hicks, R.M. International journal of experimental pathology. (1992) [Pubmed]
  5. Atrophy induced in the tubules of the testes of Syrian hamsters by two retinoids. Stinson, S.F., Reznik-Schüller, H., Reznik, G., Donahoe, R. Toxicology (1980) [Pubmed]
  6. Retinoid toxicity. Turton, J.A., Hicks, R.M., Gwynne, J., Hunt, R., Hawkey, C.M. Ciba Found. Symp. (1985) [Pubmed]
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