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Chemical Compound Review

carbenoxolone     (2S,4aS,6aS,6bR,8aR,10S,12aS,1 4bR)-10-(3...

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High impact information on carbenoxolone

  • Both DOC and CBX increased systolic blood pressure, heart, and kidney weight, and expression of cyclooxygenase 2, ED-1-positive macrophages, and osteopontin, with effects of both DOC and CBX blocked by the selective MR antagonist eplerenone [1].
  • To examine whether electrotonic coupling plays a role in mediating a specific set of DA receptor-mediated motor behaviors, we tested the effects of two inhibitors of gap junction conductance, carbenoxolone (CARB) and anandamide (AEA), on apomorphine (APO)-induced motor responses [2].
  • We then used intra-striatal infusions of CARB to determine the role of electrotonic coupling specifically in the ventral striatum in the expression of APO-induced behaviors [2].
  • Our results show that both GZA- and CBX-treated cells express alpha 1 connexin (connexin43) [3].
  • The IC50 values for SU-88 and CBX were approximately 20 and 40 microM respectively [4].

Gene context of carbenoxolone

  • A single 1.8 11 beta-HSD 1 transcript was detected, and its abundance was reduced by CBX [5].
  • Given that none of the above steroids are substrates for 11 beta-OHSD it is unlikely that the inhibition of this enzyme is involved in the unmasking of the Na+ retention observed when these substances are given to CBX-treated animals [6].


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