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Gene Review

HSD11B1  -  hydroxysteroid (11-beta) dehydrogenase 1

Homo sapiens

Synonyms: 11-DH, 11-beta-HSD1, 11-beta-hydroxysteroid dehydrogenase 1, CORTRD2, Corticosteroid 11-beta-dehydrogenase isozyme 1, ...
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Disease relevance of HSD11B1


Psychiatry related information on HSD11B1


High impact information on HSD11B1

  • Perhaps studies of different forms of apoB and apoE and of HDL subgroups and hyper-alpha-lipoproteinemia will explain why certain individuals develop hypercholesterolemia and premature atherosclerosis [11].
  • These individuals have mutations in both HSD11B1 and H6PD in a triallelic digenic model of inheritance, resulting in low 11beta-HSD1 expression and ER NADPH generation with loss of 11beta-HSD1 oxo-reductase activity [12].
  • This suggests a defect in the gene HSD11B1 encoding 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), a primary regulator of tissue-specific glucocorticoid bioavailability [12].
  • RESULTS: The mean levels of LDL and HDL cholesterol were unaltered in the antioxidant group and the placebo group; these levels changed substantially (by -42 percent and +26 percent, respectively) in the simvastatin-niacin group [13].
  • METHODS: In a three-year, double-blind trial, 160 patients with coronary disease, low HDL cholesterol levels and normal LDL cholesterol levels were randomly assigned to receive one of four regimens: simvastatin plus niacin, vitamins, simvastatin-niacin plus antioxidants; or placebos [13].

Chemical compound and disease context of HSD11B1


Biological context of HSD11B1


Anatomical context of HSD11B1


Associations of HSD11B1 with chemical compounds


Physical interactions of HSD11B1


Regulatory relationships of HSD11B1


Other interactions of HSD11B1


Analytical, diagnostic and therapeutic context of HSD11B1


  1. 11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle. Nair, S., Lee, Y.H., Lindsay, R.S., Walker, B.R., Tataranni, P.A., Bogardus, C., Baier, L.J., Permana, P.A. Diabetologia (2004) [Pubmed]
  2. Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11 beta-hydroxysteroid dehydrogenase type 2 gene. Stewart, P.M., Krozowski, Z.S., Gupta, A., Milford, D.V., Howie, A.J., Sheppard, M.C., Whorwood, C.B. Lancet (1996) [Pubmed]
  3. Abnormal expression of 11 beta-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation. Rabbitt, E.H., Ayuk, J., Boelaert, K., Sheppard, M.C., Hewison, M., Stewart, P.M., Gittoes, N.J. Oncogene (2003) [Pubmed]
  4. A new compound heterozygous mutation in the 11 beta-hydroxysteroid dehydrogenase type 2 gene in a case of apparent mineralocorticoid excess. Kitanaka, S., Katsumata, N., Tanae, A., Hibi, I., Takeyama, K., Fuse, H., Kato, S., Tanaka, T. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  5. Role of local 11 beta-hydroxysteroid dehydrogenase type 2 expression in determining the phenotype of adrenal adenomas. Mune, T., Morita, H., Suzuki, T., Takahashi, Y., Isomura, Y., Tanahashi, T., Daido, H., Yamakita, N., Deguchi, T., Sasano, H., White, P.C., Yasuda, K. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  6. Lack of Association of the 11{beta}-Hydroxysteroid Dehydrogenase Type 1 Gene 83,557insA and Hexose-6-Phosphate Dehydrogenase Gene R453Q Polymorphisms with Body Composition, Adrenal Androgen Production, Blood Pressure, Glucose Metabolism, and Dementia. Smit, P., Dekker, M.J., de Jong, F.J., van den Beld, A.W., Koper, J.W., Pols, H.A., Brinkmann, A.O., de Jong, F.H., Breteler, M.M., Lamberts, S.W. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  7. Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1) and lifetime cognitive change. Deary, I.J., Hayward, C., Permana, P.A., Nair, S., Whalley, L.J., Starr, J.M., Chapman, K.E., Walker, B.R., Seckl, J.R. Neurosci. Lett. (2006) [Pubmed]
  8. The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: the Suita study. Takagi, S., Baba, S., Iwai, N., Fukuda, M., Katsuya, T., Higaki, J., Mannami, T., Ogata, J., Goto, Y., Ogihara, T. Hypertens. Res. (2001) [Pubmed]
  9. HDL cholesterol across a spectrum of physical activity from quadriplegia to marathon running. LaPorte, R.E., Brenes, G., Dearwater, S., Murphy, M.A., Cauley, J.A., Dietrick, R., Robertson, R. Lancet (1983) [Pubmed]
  10. Some coronary risk factors related to the insulin resistance syndrome and treatment with gemfibrozil. Experience from the Helsinki Heart Study. Tenkanen, L., Mänttäri, M., Manninen, V. Circulation (1995) [Pubmed]
  11. Transport of cholesterol. Norum, K.R., Berg, T., Helgerud, P., Drevon, C.A. Physiol. Rev. (1983) [Pubmed]
  12. Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. Draper, N., Walker, E.A., Bujalska, I.J., Tomlinson, J.W., Chalder, S.M., Arlt, W., Lavery, G.G., Bedendo, O., Ray, D.W., Laing, I., Malunowicz, E., White, P.C., Hewison, M., Mason, P.J., Connell, J.M., Shackleton, C.H., Stewart, P.M. Nat. Genet. (2003) [Pubmed]
  13. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. Brown, B.G., Zhao, X.Q., Chait, A., Fisher, L.D., Cheung, M.C., Morse, J.S., Dowdy, A.A., Marino, E.K., Bolson, E.L., Alaupovic, P., Frohlich, J., Albers, J.J. N. Engl. J. Med. (2001) [Pubmed]
  14. Urinary free cortisone and the assessment of 11 beta-hydroxysteroid dehydrogenase activity in man. Palermo, M., Shackleton, C.H., Mantero, F., Stewart, P.M. Clin. Endocrinol. (Oxf) (1996) [Pubmed]
  15. Association of systemic chemokine concentrations with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4). Herder, C., Haastert, B., Müller-Scholze, S., Koenig, W., Thorand, B., Holle, R., Wichmann, H.E., Scherbaum, W.A., Martin, S., Kolb, H. Diabetes (2005) [Pubmed]
  16. SERMs: evolutionary chemistry, revolutionary biology. Miller, C.P. Curr. Pharm. Des. (2002) [Pubmed]
  17. Use of markers of dyslipidemia to identify overweight youth with insulin resistance. Hannon, T.S., Bacha, F., Lee, S.J., Janosky, J., Arslanian, S.A. Pediatric diabetes. (2006) [Pubmed]
  18. Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT. Kypreos, K.E., Zannis, V.I. Biochem. J. (2007) [Pubmed]
  19. Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism. Draper, N., Echwald, S.M., Lavery, G.G., Walker, E.A., Fraser, R., Davies, E., Sørensen, T.I., Astrup, A., Adamski, J., Hewison, M., Connell, J.M., Pedersen, O., Stewart, P.M. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  20. 11 beta-Hydroxysteroid dehydrogenase type II in the human endometrium: localization and activity during the menstrual cycle. Smith, R.E., Salamonsen, L.A., Komesaroff, P.A., Li, K.X., Myles, K.M., Lawrence, M., Krozowski, Z. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  21. 11 beta-Hydroxysteroid dehydrogenase. Stewart, P.M., Krozowski, Z.S. Vitam. Horm. (1999) [Pubmed]
  22. Regulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity and mRNA in human choriocarcinoma cells. Pasquarette, M.M., Stewart, P.M., Ricketts, M.L., Imaishi, K., Mason, J.I. J. Mol. Endocrinol. (1996) [Pubmed]
  23. 11 beta-Hydroxysteroid dehydrogenase 1 activity and gene expression in human adipose stromal cells: effect on aromatase activity. Yang, K., Khalil, M.W., Strutt, B.J., Killinger, D.W. J. Steroid Biochem. Mol. Biol. (1997) [Pubmed]
  24. Genotypes at 11beta-hydroxysteroid dehydrogenase type 11B1 and hexose-6-phosphate dehydrogenase loci are not risk factors for apparent cortisone reductase deficiency in a large population-based sample. White, P.C. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  25. Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: studies with the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone. Lindsay, R.S., Lindsay, R.M., Waddell, B.J., Seckl, J.R. Diabetologia (1996) [Pubmed]
  26. Genetic association of 11 beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) flanking microsatellites with essential hypertension in blacks. Watson, B., Bergman, S.M., Myracle, A., Callen, D.F., Acton, R.T., Warnock, D.G. Hypertension (1996) [Pubmed]
  27. The human 11 beta-hydroxysteroid dehydrogenase type II enzyme: comparisons with other species and localization to the distal nephron. Krozowski, Z., Albiston, A.L., Obeyesekere, V.R., Andrews, R.K., Smith, R.E. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  28. CLA-1 is an 85-kD plasma membrane glycoprotein that acts as a high-affinity receptor for both native (HDL, LDL, and VLDL) and modified (OxLDL and AcLDL) lipoproteins. Calvo, D., Gómez-Coronado, D., Lasunción, M.A., Vega, M.A. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  29. Bacterial lipopolysaccharides: structure, metabolism and mechanisms of action. Freudenberg, M.A., Galanos, C. Int. Rev. Immunol. (1990) [Pubmed]
  30. Type 2 11 beta-hydroxysteroid dehydrogenase in foetal and adult life. Stewart, P.M., Whorwood, C.B., Mason, J.I. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  31. Growth hormone replacement inhibits renal and hepatic 11 beta-hydroxysteroid dehydrogenases in ACTH-deficient patients. Walker, B.R., Andrew, R., MacLeod, K.M., Padfield, P.L. Clin. Endocrinol. (Oxf) (1998) [Pubmed]
  32. Corticotropin-releasing hormone system in human adipose tissue. Seres, J., Bornstein, S.R., Seres, P., Willenberg, H.S., Schulte, K.M., Scherbaum, W.A., Ehrhart-Bornstein, M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  33. Regulation of 11 beta-hydroxysteroid dehydrogenase activity in human skin fibroblasts: enzymatic modulation of glucocorticoid action. Hammami, M.M., Siiteri, P.K. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  34. Gene structure and chromosomal localization of the human HSD11K gene encoding the kidney (type 2) isozyme of 11 beta-hydroxysteroid dehydrogenase. Agarwal, A.K., Rogerson, F.M., Mune, T., White, P.C. Genomics (1995) [Pubmed]
  35. The effect of growth hormone replacement therapy on cortisol-cortisone interconversion in hypopituitary adults: evidence for growth hormone modulation of extrarenal 11 beta-hydroxysteroid dehydrogenase activity. Gelding, S.V., Taylor, N.F., Wood, P.J., Noonan, K., Weaver, J.U., Wood, D.F., Monson, J.P. Clin. Endocrinol. (Oxf) (1998) [Pubmed]
  36. Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women: the hoorn study. Snijder, M.B., Heine, R.J., Seidell, J.C., Bouter, L.M., Stehouwer, C.D., Nijpels, G., Funahashi, T., Matsuzawa, Y., Shimomura, I., Dekker, J.M. Diabetes Care (2006) [Pubmed]
  37. Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors. Korbonits, M., Bujalska, I., Shimojo, M., Nobes, J., Jordan, S., Grossman, A.B., Stewart, P.M. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  38. Modulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity in Ishikawa cells is associated with changes in cellular proliferation. Koyama, K., Krozowski, Z. Mol. Cell. Endocrinol. (2001) [Pubmed]
  39. 11 beta-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity. Rajan, V., Edwards, C.R., Seckl, J.R. J. Neurosci. (1996) [Pubmed]
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