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Chemical Compound Review

SureCN995030     N-[(2S,3S,5R)-5- aminocarbonyl-1-(3...

Synonyms: AG-E-56008, CHEMBL1628706, AC1NSK1E, CTK4E6340, CP-481715, ...
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Disease relevance of CP-481,715

  • In a more generalized model of inflammation, delayed-type hypersensitivity, CP-481,715 significantly inhibited footpad swelling and decreased the amount of IFN-gamma and IL-2 produced by isolated spleen cells from sensitized animals [1].

High impact information on CP-481,715


Biological context of CP-481,715

  • Radiolabeled binding studies indicate that CP-481,715 binds to human CCR1 with a Kd of 9.2 nm and displaces 125I-labeled CCL3 from CCR1-transfected cells with an IC50 of 74 nm [2].

Gene context of CP-481,715


  1. The human specific CCR1 antagonist CP-481,715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice. Gladue, R.P., Cole, S.H., Roach, M.L., Tylaska, L.A., Nelson, R.T., Shepard, R.M., McNeish, J.D., Ogborne, K.T., Neote, K.S. J. Immunol. (2006) [Pubmed]
  2. CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases. Gladue, R.P., Tylaska, L.A., Brissette, W.H., Lira, P.D., Kath, J.C., Poss, C.S., Brown, M.F., Paradis, T.J., Conklyn, M.J., Ogborne, K.T., McGlynn, M.A., Lillie, B.M., DiRico, A.P., Mairs, E.N., McElroy, E.B., Martin, W.H., Stock, I.A., Shepard, R.M., Showell, H.J., Neote, K. J. Biol. Chem. (2003) [Pubmed]
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