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Chemical Compound Review:

Artemetin 2-(3,4-dimethoxyphenyl)-5- hydroxy-3,6,7...

Synonyms: Artemisetin, AC1NSZD5, CHEMBL225700, SureCN2122576, MEGxp0_002022, ...

Li, W.X. et al., Ko, W.G. et al., Sertié, J.A. et al., Bayeux, M.C. et al., Sánchez, I. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Artemisetin

Artemetin significantly inhibited carrageenin-induced paw edema following oral doses from 30.4 to 153.9 mg.kg-1 [1].
Anti-inflammatory activity and sub-acute toxicity of artemetin [1].
Three polymethoxyflavonoids from the fruit of Vitex rotundifolia, namely 2',3',5-trihydroxy-3,6,7-trimethoxyflavone (Vx-1), vitexicarpin (Vx-5) and artemetin (Vx-6), were tested for their antiproliferative activity in human myeloid leukemia HL-60 cells [2].

High impact information on Artemisetin

Six flavonoids, persicogenin (1), artemetin (2), luteolin (3), penduletin (4), vitexicarpin (5) and chrysosplenol-D (6), have been isolated for the first time as new cell cycle inhibitors from Vitex trifolia L., a Chinese folk medicine used to treat cancers, through a bioassay-guided separation procedure [3].
Agehoustin B and artemetin, which lack a methoxy group at C-8 (RI), were not cytotoxic for the cells (19% and 16% cell death) [4].

Chemical compound and disease context of Artemisetin

Indomethacin (10 mg/kg, po, N = 6) reduced the edema by 45 and 48%, after 4 and 5 h, but the artemetin-enriched fraction (30, 100 and 300 mg/kg, po, N = 6) had no activity [5].

References

Anti-inflammatory activity and sub-acute toxicity of artemetin. Sertié, J.A., Basile, A.C., Panizza, S., Matida, A.K., Zelnik, R. Planta Med. (1990) [Pubmed]
Polymethoxyflavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells. Ko, W.G., Kang, T.H., Lee, S.J., Kim, N.Y., Kim, Y.C., Sohn, D.H., Lee, B.H. Food Chem. Toxicol. (2000) [Pubmed]
Flavonoids from Vitex trifolia L. inhibit cell cycle progression at G2/M phase and induce apoptosis in mammalian cancer cells. Li, W.X., Cui, C.B., Cai, B., Wang, H.Y., Yao, X.S. Journal of Asian natural products research. (2005) [Pubmed]
In vitro cytotoxicity of flavonoids against MK2 and C6 tumour cells. Sánchez, I., Calderón, J., Ruiz, B., Tellez, J., Calzada, L., Taboada, J. Phytotherapy research : PTR. (2001) [Pubmed]
Evaluation of the antiedematogenic activity of artemetin isolated from Cordia curassavica DC. Bayeux, M.C., Fernandes, A.T., Foglio, M.A., Carvalho, J.E. Braz. J. Med. Biol. Res. (2002) [Pubmed]

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