Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN8738868 17-[(E)-2,6-dihydroxy-6- methyl-3-oxo-hept...

Synonyms: AC1NS4BJ, MLS002702902, SMR001566719

Graness, A. et al., Molavi, O. et al., Lim, C.P. et al., Shi, X. et al.

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High impact information on Cucurbitacin I

Inhibition of Stat3 expression and phosphorylation by short interfering RNA or Cucurbitacin I resulted in the loss of collagen production, impaired proliferation and delayed cell migration in KFs [1].
STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I [2].
In the present study the effect of cucurbitacin I was investigated in fibroblasts [2].
Immunocytochemical analysis of cucurbitacin I-treated cells revealed disassembly of F-actin fibres, reorganisation into F-actin patches and resolution of focal adhesions [2].
Concentrations of cucurbitacin I, which have been shown to target Jak2-STAT3 signalling, thus, profoundly affect the actin cytoskeleton and may therefore modulate cell morphology, migration, adherence and gene expression also in non-tumour cells [2].

Associations of Cucurbitacin I with other chemical compounds

JSI-124 (cucurbitacin I) has been recently described as a specific inhibitor of signal transducer and activator of transcription-3 (STAT3) [3].

Gene context of Cucurbitacin I

PURPOSE: To develop a liquid chromatography/mass spectrometry (LC-MS) method for the quantitative analysis of cucurbitacin I (JSI-124), an anti-cancer inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway, in rat plasma samples [4].

Analytical, diagnostic and therapeutic context of Cucurbitacin I

Development of a sensitive and specific liquid chromatography/mass spectrometry method for the quantification of cucurbitacin I (JSI-124) in rat plasma [4].

References

Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration. Lim, C.P., Phan, T.T., Lim, I.J., Cao, X. Oncogene (2006) [Pubmed]
STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I. Graness, A., Poli, V., Goppelt-Struebe, M. Biochem. Pharmacol. (2006) [Pubmed]
JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells. Shi, X., Franko, B., Frantz, C., Amin, H.M., Lai, R. Br. J. Haematol. (2006) [Pubmed]
Development of a sensitive and specific liquid chromatography/mass spectrometry method for the quantification of cucurbitacin I (JSI-124) in rat plasma. Molavi, O., Shayeganpour, A., Somayaji, V., Hamdy, S., R Brocks, D., Lavasanifar, A., Kwon, G.S., Samuel, J. Journal of pharmacy & pharmaceutical sciences [electronic resource] : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques. (2006) [Pubmed]

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