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Gene Review

Ctgf  -  connective tissue growth factor

Mus musculus

Synonyms: CCN family member 2, Ccn2, Connective tissue growth factor, Fisp-12, Fisp12, ...
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Disease relevance of Ctgf


High impact information on Ctgf


Chemical compound and disease context of Ctgf


Biological context of Ctgf


Anatomical context of Ctgf


Associations of Ctgf with chemical compounds


Regulatory relationships of Ctgf


Other interactions of Ctgf


Analytical, diagnostic and therapeutic context of Ctgf


  1. Activation of connective tissue growth factor gene by the c-Maf and Lc-Maf transcription factors. Omoteyama, K., Ikeda, H., Imaki, J., Sakai, M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  2. Deletion of Protein Kinase C-{beta} Isoform In Vivo Reduces Renal Hypertrophy but Not Albuminuria in the Streptozotocin-Induced Diabetic Mouse Model. Meier, M., Park, J.K., Overheu, D., Kirsch, T., Lindschau, C., Gueler, F., Leitges, M., Menne, J., Haller, H. Diabetes (2007) [Pubmed]
  3. Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis. Okada, H., Kikuta, T., Kobayashi, T., Inoue, T., Kanno, Y., Takigawa, M., Sugaya, T., Kopp, J.B., Suzuki, H. J. Am. Soc. Nephrol. (2005) [Pubmed]
  4. DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition. Higgins, D.F., Lappin, D.W., Kieran, N.E., Anders, H.J., Watson, R.W., Strutz, F., Schlondorff, D., Haase, V.H., Fitzpatrick, J.M., Godson, C., Brady, H.R. Kidney Int. (2003) [Pubmed]
  5. Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction. Chuva de Sousa Lopes, S.M., Feijen, A., Korving, J., Korchynskyi, O., Larsson, J., Karlsson, S., ten Dijke, P., Lyons, K.M., Goldschmeding, R., Doevendans, P., Mummery, C.L. Dev. Dyn. (2004) [Pubmed]
  6. Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin. Kamada, Y., Tamura, S., Kiso, S., Matsumoto, H., Saji, Y., Yoshida, Y., Fukui, K., Maeda, N., Nishizawa, H., Nagaretani, H., Okamoto, Y., Kihara, S., Miyagawa, J., Shinomura, Y., Funahashi, T., Matsuzawa, Y. Gastroenterology (2003) [Pubmed]
  7. Generation of the primary hair follicle pattern. Mou, C., Jackson, B., Schneider, P., Overbeek, P.A., Headon, D.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  8. Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Babic, A.M., Chen, C.C., Lau, L.F. Mol. Cell. Biol. (1999) [Pubmed]
  9. Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis. Dornhöfer, N., Spong, S., Bennewith, K., Salim, A., Klaus, S., Kambham, N., Wong, C., Kaper, F., Sutphin, P., Nacamuli, R., Nacalumi, R., Höckel, M., Le, Q., Longaker, M., Yang, G., Koong, A., Giaccia, A. Cancer Res. (2006) [Pubmed]
  10. Connective tissue growth factor: a novel marker of layer VII neurons in the rat cerebral cortex. Heuer, H., Christ, S., Friedrichsen, S., Brauer, D., Winckler, M., Bauer, K., Raivich, G. Neuroscience (2003) [Pubmed]
  11. Connective Tissue Growth Factor is a Biomarker and Mediator of Kidney Allograft Fibrosis. Cheng, O., Thuillier, R., Sampson, E., Schultz, G., Ruiz, P., Zhang, X., Yuen, P.S., Mannon, R.B. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2006) [Pubmed]
  12. Connective tissue growth factor is crucial to inducing a profibrotic environment in "fibrosis-resistant" BALB/c mouse lungs. Bonniaud, P., Martin, G., Margetts, P.J., Ask, K., Robertson, J., Gauldie, J., Kolb, M. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  13. Localization of connective tissue growth factor during the period of embryo implantation in the mouse. Surveyor, G.A., Wilson, A.K., Brigstock, D.R. Biol. Reprod. (1998) [Pubmed]
  14. Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. Vergnes, L., Phan, J., Strauss, M., Tafuri, S., Reue, K. J. Biol. Chem. (2003) [Pubmed]
  15. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Ivkovic, S., Yoon, B.S., Popoff, S.N., Safadi, F.F., Libuda, D.E., Stephenson, R.C., Daluiski, A., Lyons, K.M. Development (2003) [Pubmed]
  16. Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer. Shimo, T., Kubota, S., Yoshioka, N., Ibaragi, S., Isowa, S., Eguchi, T., Sasaki, A., Takigawa, M. J. Bone Miner. Res. (2006) [Pubmed]
  17. Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development. Kireeva, M.L., Latinkić, B.V., Kolesnikova, T.V., Chen, C.C., Yang, G.P., Abler, A.S., Lau, L.F. Exp. Cell Res. (1997) [Pubmed]
  18. Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-beta produced by tubular epithelial cells in response to high glucose. Kobayashi, T., Inoue, T., Okada, H., Kikuta, T., Kanno, Y., Nishida, T., Takigawa, M., Sugaya, T., Suzuki, H. Clin. Exp. Nephrol. (2005) [Pubmed]
  19. Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium. He, Z., Way, K.J., Arikawa, E., Chou, E., Opland, D.M., Clermont, A., Isshiki, K., Ma, R.C., Scott, J.A., Schoen, F.J., Feener, E.P., King, G.L. J. Biol. Chem. (2005) [Pubmed]
  20. Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3). Jedsadayanmata, A., Chen, C.C., Kireeva, M.L., Lau, L.F., Lam, S.C. J. Biol. Chem. (1999) [Pubmed]
  21. Fetal and adult fibroblasts have similar TGF-beta-mediated, Smad-dependent signaling pathways. Colwell, A.S., Krummel, T.M., Longaker, M.T., Lorenz, H.P. Plast. Reconstr. Surg. (2006) [Pubmed]
  22. The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor. Segarini, P.R., Nesbitt, J.E., Li, D., Hays, L.G., Yates, J.R., Carmichael, D.F. J. Biol. Chem. (2001) [Pubmed]
  23. STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I. Graness, A., Poli, V., Goppelt-Struebe, M. Biochem. Pharmacol. (2006) [Pubmed]
  24. Gene expression of connective tissue growth factor in adult mouse. Friedrichsen, S., Heuer, H., Christ, S., Cuthill, D., Bauer, K., Raivich, G. Growth Factors (2005) [Pubmed]
  25. Antifibrotic, nephroprotective potential of ACE inhibitor vs AT1 antagonist in a murine model of renal fibrosis. Gross, O., Schulze-Lohoff, E., Koepke, M.L., Beirowski, B., Addicks, K., Bloch, W., Smyth, N., Weber, M. Nephrol. Dial. Transplant. (2004) [Pubmed]
  26. Effect of connective tissue growth factor on hypoxia-inducible factor 1alpha degradation and tumor angiogenesis. Chang, C.C., Lin, M.T., Lin, B.R., Jeng, Y.M., Chen, S.T., Chu, C.Y., Chen, R.J., Chang, K.J., Yang, P.C., Kuo, M.L. J. Natl. Cancer Inst. (2006) [Pubmed]
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