The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

MOLI001064     hydroxylamine

Synonyms: AC1L9OZZ
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of hydroxylamine


Psychiatry related information on hydroxylamine


High impact information on hydroxylamine

  • The structure reveals that the caspase is inhibited in the active site through a covalent thioester linkage to p35, which we confirmed by gel electrophoresis, hydroxylamine treatment and mass spectrometry experiments [8].
  • Here we show that a novel cytoprotective hydroxylamine derivative, [2-hydroxy-3-(1-piperidinyl) propoxy]-3-pyridinecarboximidoil-chloride maleate, Bimoclomol, facilitates the formation of chaperone molecules in eukaryotic cells by inducing or amplifying expression of heat-shock genes [9].
  • Nineteen independently isolated adr1 mutations induced by hydroxylamine were found at nine different amino-acid positions, seven of which are in the two finger domains [10].
  • The resistance of the acyl fatty acid moiety to hydrolysis by hydroxylamine suggested that the covalent linkage to the 36-kD protein may be through an amide linkage [11].
  • By mutagenizing plasmid DNA in vitro with hydroxylamine and applying this phenotypic screen, we have isolated five distinct single amino acid substitution mutants, each of which shows a biochemical phenotype, that is, greater than or equal to 90% reduction in specific DNA relaxing activity of the mutant protein relative to wild type [12].

Chemical compound and disease context of hydroxylamine


Biological context of hydroxylamine


Anatomical context of hydroxylamine


Associations of hydroxylamine with other chemical compounds


Gene context of hydroxylamine


Analytical, diagnostic and therapeutic context of hydroxylamine


  1. Functional mutants of phenylalanine transfer RNA from Escherichia coli. Vacher, J., Springer, M., Buckingham, R.H. EMBO J. (1985) [Pubmed]
  2. Diagnosis of sulfonamide hypersensitivity reactions by in-vitro "rechallenge" with hydroxylamine metabolites. Rieder, M.J., Uetrecht, J., Shear, N.H., Cannon, M., Miller, M., Spielberg, S.P. Ann. Intern. Med. (1989) [Pubmed]
  3. A genetic screen for mutations that increase the thermal stability of phage T4 lysozyme. Alber, T., Wozniak, J.A. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  4. The anaerobic oxidation of ammonium. Jetten, M.S., Strous, M., van de Pas-Schoonen, K.T., Schalk, J., van Dongen, U.G., van de Graaf, A.A., Logemann, S., Muyzer, G., van Loosdrecht, M.C., Kuenen, J.G. FEMS Microbiol. Rev. (1998) [Pubmed]
  5. Screening for thermostable mutant of kanamycin nucleotidyltransferase by the use of a transformation system for a thermophile, Bacillus stearothermophilus. Matsumura, M., Aiba, S. J. Biol. Chem. (1985) [Pubmed]
  6. The effect of beta-amyloid on neurons and the influence of glucocorticoid and age on such effect. Chen, H., Sun, S., Mei, Y., Liu, C., Liu, A., Tong, E. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2002) [Pubmed]
  7. N-acetyltransferases: pharmacogenetics and clinical consequences of polymorphic drug metabolism. Spielberg, S.P. Journal of pharmacokinetics and biopharmaceutics. (1996) [Pubmed]
  8. Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex. Xu, G., Cirilli, M., Huang, Y., Rich, R.L., Myszka, D.G., Wu, H. Nature (2001) [Pubmed]
  9. Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects. Vígh, L., Literáti, P.N., Horváth, I., Török, Z., Balogh, G., Glatz, A., Kovács, E., Boros, I., Ferdinándy, P., Farkas, B., Jaszlits, L., Jednákovits, A., Korányi, L., Maresca, B. Nat. Med. (1997) [Pubmed]
  10. Two zinc fingers of a yeast regulatory protein shown by genetic evidence to be essential for its function. Blumberg, H., Eisen, A., Sledziewski, A., Bader, D., Young, E.T. Nature (1987) [Pubmed]
  11. The 36-kilodalton substrate of pp60v-src is myristylated in a transformation-sensitive manner. Soric, J., Gordon, J.A. Science (1985) [Pubmed]
  12. Phenotypic selection and characterization of mutant alleles of a eukaryotic DNA topoisomerase I. Morham, S.G., Shuman, S. Genes Dev. (1990) [Pubmed]
  13. Evidence for functional interaction between domains II and V of 23S ribosomal RNA from an erythromycin-resistant mutant. Douthwaite, S., Prince, J.B., Noller, H.F. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  14. Complete amino acid sequence of the group-specific antigen gene-encoded phosphorylated proteins of mouse leukemia viruses. Versteegen, R.J., Copeland, T.D., Oroszlan, S. J. Biol. Chem. (1982) [Pubmed]
  15. Histidine decarboxylase of Lactobacillus 30a. Hydroxylamine cleavage of the -seryl-seryl- bond at the activation site of prohistidine decarboxylase. Huynh, Q.K., Snell, E.E. J. Biol. Chem. (1986) [Pubmed]
  16. Hydroxylamine assimilation by Rhodobacter capsulatus E1F1. requirement of the hcp gene (hybrid cluster protein) located in the nitrate assimilation nas gene region for hydroxylamine reduction. Cabello, P., Pino, C., Olmo-Mira, M.F., Castillo, F., Roldán, M.D., Moreno-Vivián, C. J. Biol. Chem. (2004) [Pubmed]
  17. Amino acid sequence of the sulfate-binding protein from Salmonella typhimurium LT2. Isihara, H., Hogg, R.W. J. Biol. Chem. (1980) [Pubmed]
  18. Characterization of two mutations in the Escherichia coli galE gene inactivating the second galactose operator and comparative studies of repressor binding. Fritz, H.J., Bicknäse, H., Gleumes, B., Heibach, C., Rosahl, S., Ehring, R. EMBO J. (1983) [Pubmed]
  19. The VPS1 protein, a homolog of dynamin required for vacuolar protein sorting in Saccharomyces cerevisiae, is a GTPase with two functionally separable domains. Vater, C.A., Raymond, C.K., Ekena, K., Howald-Stevenson, I., Stevens, T.H. J. Cell Biol. (1992) [Pubmed]
  20. Analysis of a tobacco mosaic virus strain capable of overcoming N gene-mediated resistance. Padgett, H.S., Beachy, R.N. Plant Cell (1993) [Pubmed]
  21. Reaction sequence and molecular mass of a Cl(-)-translocating P-type ATPase. Gerencser, G.A., Zelezna, B. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  22. Human prostate-specific antigen: structural and functional similarity with serine proteases. Watt, K.W., Lee, P.J., M'Timkulu, T., Chan, W.P., Loor, R. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  23. The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase. Yu, J., Nagarajan, S., Knez, J.J., Udenfriend, S., Chen, R., Medof, M.E. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  24. Myristoylation and the post-translational acquisition of hydrophobicity by the membrane immunoglobulin heavy-chain polypeptide in B lymphocytes. Pillai, S., Baltimore, D. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  25. Amino acid-specific ADP-ribosylation. Sensitivity to hydroxylamine of [cysteine(ADP-ribose)]protein and [arginine(ADP-ribose)]protein linkages. Hsia, J.A., Tsai, S.C., Adamik, R., Yost, D.A., Hewlett, E.L., Moss, J. J. Biol. Chem. (1985) [Pubmed]
  26. N-terminal sequence and distal histidine residues are responsible for pH-regulated cytoplasmic membrane binding of human AMP deaminase isoform E. Mahnke-Zizelman, D.K., Sabina, R.L. J. Biol. Chem. (2002) [Pubmed]
  27. Low basal transcription of genes for tissue-specific collagens by fibroblasts and lymphoblastoid cells. Application to the characterization of a glycine 997 to serine substitution in alpha 1(II) collagen chains of a patient with spondyloepiphyseal dysplasia. Chan, D., Cole, W.G. J. Biol. Chem. (1991) [Pubmed]
  28. Acetylcholine receptor-associated 43K protein contains covalently bound myristate. Musil, L.S., Carr, C., Cohen, J.B., Merlie, J.P. J. Cell Biol. (1988) [Pubmed]
  29. Heme packing motifs revealed by the crystal structure of the tetra-heme cytochrome c554 from Nitrosomonas europaea. Iverson, T.M., Arciero, D.M., Hsu, B.T., Logan, M.S., Hooper, A.B., Rees, D.C. Nat. Struct. Biol. (1998) [Pubmed]
  30. Coronary thrombolysis with facilitated absorption of intramuscularly injected tissue-type plasminogen activator. Sobel, B.E., Fields, L.E., Robison, A.K., Fox, K.A., Sarnoff, S.J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  31. Inhibition of assimilatory nitrate reductase activity in soil by glutamine and ammonium analogs. McCarty, G.W., Bremner, J.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  32. Acylation stabilizes a protease-resistant conformation of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides. Arnould, S., Takahashi, M., Camadro, J.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  33. Specific complex formation between proteins encoded by the yeast DNA repair and recombination genes RAD1 and RAD10. Bailly, V., Sommers, C.H., Sung, P., Prakash, L., Prakash, S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  34. Isolation and characterization of temperature-sensitive mutations in RPA190, the gene encoding the largest subunit of RNA polymerase I from Saccharomyces cerevisiae. Wittekind, M., Dodd, J., Vu, L., Kolb, J.M., Buhler, J.M., Sentenac, A., Nomura, M. Mol. Cell. Biol. (1988) [Pubmed]
  35. Binding of IL-1 beta to alpha-macroglobulins and release by thioredoxin. Borth, W., Scheer, B., Urbansky, A., Luger, T.A., Sottrup-Jensen, L. J. Immunol. (1990) [Pubmed]
  36. Assignment of the binding site for haptoglobin on apolipoprotein A-I. Spagnuolo, M.S., Cigliano, L., D'Andrea, L.D., Pedone, C., Abrescia, P. J. Biol. Chem. (2005) [Pubmed]
  37. Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2. Kuffel, M.J., Schroeder, J.C., Pobst, L.J., Naylor, S., Reid, J.M., Kaufmann, S.H., Ames, M.M. Mol. Pharmacol. (2002) [Pubmed]
  38. Latent tissue plasminogen activator produced by human endothelial cells in culture: evidence for an enzyme-inhibitor complex. Levin, E.G. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  39. A switch in heme axial ligation prepares Paracoccus pantotrophus cytochrome cd1 for catalysis. Allen, J.W., Watmough, N.J., Ferguson, S.J. Nat. Struct. Biol. (2000) [Pubmed]
  40. Analysis of yeast DNA topoisomerase II mutants resistant to the antitumor drug amsacrine. Wasserman, R.A., Wang, J.C. Cancer Res. (1994) [Pubmed]
  41. Isolation and complete amino acid sequence of the mitochondrial ATP synthase epsilon-subunit of the yeast Saccharomyces cerevisiae. Arselin, G., Gandar, J.C., Guérin, B., Velours, J. J. Biol. Chem. (1991) [Pubmed]
  42. Localization of the diphtheria toxin receptor-binding domain to the carboxyl-terminal Mr approximately 6000 region of the toxin. Rolf, J.M., Gaudin, H.M., Eidels, L. J. Biol. Chem. (1990) [Pubmed]
WikiGenes - Universities