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Chemical Compound Review:

CHEMBL77510 (2E)-2-(nitrosomethylidene)- 1H-pyridine

Synonyms: CCRIS 7743, NSC-66484, P-2-A, NSC66484, SBB004284, ...

Atoda, H. et al., Moritoki, H. et al., Sanchez-Hernandez, J.C. et al., Byrne, D.H. et al., Adebodun, F. et al., et al.

Sanchez-Hernandez, Sanchez,

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High impact information on Pikolinealdoxime

95 % reactivation from inhibited AChE could be regenerated by using 2-pyridinealdoxime methiodide within 15 min for 15 times [1].
Cationic oximes that are excellent reactivators of OP-inhibited acetylcholinesterase, such as pyridine-2-aldoxime or the bis-pyridine aldoximes, HI-6 and TMB-4, produced poor reactivation of OP-inhibited CaE [2].
On the other hand, 2-pyridinealdoxime methochloride, which offers little or no protection against micromelia in ovo, did protect both the proliferative and chondrogenic activities of the limb bud cells in micromass culture [3].
When the phosphorylated acetylcholinesterase was reactivated with 10(-3) pyridine-2-aldoxime methiodide, MEPP frequency was reduced significantly and antidromic activity was abolished [4].
The same NMR technique was used to determine the action of PAM (pyridine-2-aldoxime methiodide, a known "antidote" for acetylcholinesterase inactivated by diisopropylfluorophosphate), on the inactivated enzymes [5].

Biological context of Pikolinealdoxime

The hydrolysis products of HI-6 were identified by NMR and MS (electron impact) as 2-pyridinealdoxime, picolinamide, and isonicotinamide, whereas that of MMB-4 was identified as 4-pyridinealdoxime [6].
Effects of 3 oximes, diacetylmonoxime (DAM), pyridine-2-aldoxime (PAM) and pyridine-2-aldoxime methochloride (2-PAM), on the normal electrical and mechanical activities and on the slow response action potentials were examined in the guinea pig ventricular muscles [7].

Anatomical context of Pikolinealdoxime

The inhibition of the response of the uterus by organophosphates was effectively removed by pyridine-2-aldoxime methiodide [8].

Associations of Pikolinealdoxime with other chemical compounds

Effects of oximes, diacetylmonoxime, pyridine-2-aldoxime, and pyridine-2-aldoxime methochloride, on the electrical and mechanical activities of guinea pig cardiac ventricular muscles [7].

Gene context of Pikolinealdoxime

The pH, substrate concentration, and specificity for ChE assays as well as the response of serum BChE to the reactivating agent pyridine-2-aldoxime methochloride (2-PAM) were also investigated in order to assess the possibilities of this methodology in biomonitoring programs [9].

References

Binding of acetylcholinesterase to multiwall carbon nanotube-cross-linked chitosan composite for flow-injection amperometric detection of an organophosphorous insecticide. Kandimalla, V.B., Ju, H. Chemistry (Weinheim an der Bergstrasse, Germany) (2006) [Pubmed]
Oxime-induced reactivation of carboxylesterase inhibited by organophosphorus compounds. Maxwell, D.M., Lieske, C.N., Brecht, K.M. Chem. Res. Toxicol. (1994) [Pubmed]
Teratogenic effects of cholinergic insecticides in chick embryos--IV. The role of tryptophan in protecting against limb deformities. Byrne, D.H., Kitos, P.A. Biochem. Pharmacol. (1983) [Pubmed]
Presynaptic effects of neuromuscular cholinesterase inhibition. Laskowski, M.B., Dettbarn, W.D. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
Multinuclear magnetic resonance studies on serine protease transition state analogues. Adebodun, F., Jordan, F. J. Cell. Biochem. (1989) [Pubmed]
Stability studies of bis(pyridiniumaldoxime) reactivators of organophosphate-inhibited acetylcholinesterase. Lin, A.J., Klayman, D.L. Journal of pharmaceutical sciences. (1986) [Pubmed]
Effects of oximes, diacetylmonoxime, pyridine-2-aldoxime, and pyridine-2-aldoxime methochloride, on the electrical and mechanical activities of guinea pig cardiac ventricular muscles. Atoda, H., Kasuya, Y., Shigenobu, K. J. Pharmacobio-dyn. (1985) [Pubmed]
Effects of cholinesterase inhibitors on the spasmogenic action of acetate esters on rat uterus. Moritoki, H., Shinohara, Y., Yamauchi, M., Ishida, Y. Eur. J. Pharmacol. (1978) [Pubmed]
Lizard cholinesterases as biomarkers of pesticide exposure: enzymological characterization. Sanchez-Hernandez, J.C., Sanchez, B.M. Environ. Toxicol. Chem. (2002) [Pubmed]

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