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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Floropryl     2-(fluoro-propan-2-yloxy...

Synonyms: Dyflos, Fluostigmine, Isoflurophate, Fluorostigmine, DFP, ...
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Disease relevance of Floropryl


Psychiatry related information on Floropryl

  • Administration of DFP in the preweanling period did not affect locomotor activity or pain reactivity [6].
  • Resumption of daily DFP at 0.1 mg/kg caused smaller impairments of both matching accuracy and response latency [7].
  • The cholinesterase inhibitor DFP facilitates the expression of paradoxical sleep (PS) propensity in rats subjected to short-term PS deprivation [8].
  • Sixty percent of the variation in DFP-induced hyperthermia, a toxic response seen > 48 h after exposure, can be explained by individual differences in baseline Tc [9].
  • In order to determine if there is a critical period for these effects, neonatal mice were given a single oral dose of 1.5 mg/kg DFP b.wt. on postnatal day 3, 10 or 19, causing equal inhibition of AChE [10].

High impact information on Floropryl


Chemical compound and disease context of Floropryl


Biological context of Floropryl


Anatomical context of Floropryl


Associations of Floropryl with other chemical compounds

  • This protease was preferentially localized in the smooth microsomal membrane and strongly inhibited by diisopropyl phosphorofluoridate (CAS: 55-91-4), and the optimum pH of the activity was 7 [30].
  • Neither corn trypsin inhibitor (36 microM) nor diisopropylfluorophosphate (3.6 mM) diminished the effect of Factor XIIa on Fc gamma RI, although each completely inhibited the coagulant and amidolytic activity contained on the light chain of Factor XIIa [31].
  • Experiments using DFP in living trypanosomes and a trypanosome cell-free system suggest that earlier GPI intermediates are also in equilibrium between their inositol acylated and nonacylated forms [32].
  • When DFP is used in vivo, 400 nmol/kg cytotoxic somatostatin analog AN-238 containing AN-201 is well tolerated by mice, whereas all animals die after the same dose without DFP [33].
  • Essentially identical results were obtained with active site-blocked forms of APC generated with either diisopropylfluorophosphate or D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone, which indicates that the active site was not essential for the liver association [34].

Gene context of Floropryl


Analytical, diagnostic and therapeutic context of Floropryl

  • We found, using light microscope autoradiography, that in the twitch fibers of the extraocular muscle, there is n average of 6.4 +/- 2.1 X 10(7) DFP-binding sites per endplate, of which 29% (1.8 X 10(7)) are reactivated by 2-PAM and are thus AChe [29].
  • Preincubation of this conditioned medium from antibody-treated cell cultures with DFP abolished the medium's ability to mediate loss of cellular adhesion [40].
  • Iodinated C3-acceptor complexes were identified by immunoprecipitation from the detergent-insoluble fraction of phagosomes prepared from DFP-treated cells ingesting S. typhimurium in the presence of 125I-Na [41].
  • There was enhanced release of vWF during activated neutrophil-endothelial cell coculture; this was not inhibited by diphenyleneiodonium or by SOD plus catalase, but was inhibited by diisopropylfluorophosphate [42].
  • Furthermore, treatment of BCV with DFP dramatically reduced its infectivity in a plaque assay [43].


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