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Chemical Compound Review

Trimedoxime     (NZ)-N-[[1-[3-[4-[(Z)- hydroxyiminomethyl]...

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Disease relevance of Trimedoxime


Psychiatry related information on Trimedoxime


High impact information on Trimedoxime


Biological context of Trimedoxime

  • Trimedoxime (24 mg/kg intravenously) was injected 5 min. before 1.3 LD50 intravenously of poisons [11].

Associations of Trimedoxime with other chemical compounds


Gene context of Trimedoxime

  • In essence, the substitution pattern influenced the inhibitory potency against AChE, where the most active bispyridiniumoxime (TMB-4) was bisbenzyl substituted followed by monobenzyl substituted, bismethyl substituted, and unsubstituted derivatives of TMB-4 [15].
  • Mono- and bisbenzyloxime ethers of the bispyridinium derivative TMB-4 (UNO, DUO) are potent allosteric modulators of the muscarinic receptor attracting clinical interest in case of organophosphate poisoning [16].
  • These organophosphorus compounds produced a significant inhibition of plasma carboxylesterase activity, while administration of trimedoxime led to regeneration of the enzyme activity [11].
  • Various oximes (PAM, toxogonin, TMB-4, HS-6, HI-6, HGG-12, HGG-42) combined with atropine were compared as antidotes of soman, sarin and tabun poisoning in non-fasted CD-1 male mice [17].


  1. Studies of the amplification of carbaryl toxicity by various oximes. Lieske, C.N., Clark, J.H., Maxwell, D.M., Zoeffel, L.D., Sultan, W.E. Toxicol. Lett. (1992) [Pubmed]
  2. Specification of the structure of oximes able to reactivate tabun-inhibited acetylcholinesterase. Cabal, J., Kuca, K., Kassa, J. Basic & clinical pharmacology & toxicology. (2004) [Pubmed]
  3. Effects of atropine, trimedoxime and methylprednisolone on the development of organophosphate-induced delayed polyneuropathy in the hen. Jokanović, M., Stepanović Petrović, R.M., Maksimović, M., Jovanovic, D., Kosanović, M., Piperski, V. Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie. (2001) [Pubmed]
  4. The treatment of delayed polyneuropathy induced by diisopropylfluorophosphate in hens. Petrović, R.M., Jokanović, M., Maksimović, M., Ugresić, N., Bosković, B. Die Pharmazie. (2000) [Pubmed]
  5. Behavioral comparison of the oximes TMB-4, 2-PAM, and HI-6 in rats using operant conditioning. Genovese, R.F., Doctor, B.P. Pharmacol. Biochem. Behav. (1997) [Pubmed]
  6. Oxime effects on the rate constants of carbamylation and decarbamylation of acetylcholinesterase for pyridostigmine, physostigmine and insecticidal carbamates. Dawson, R.M. Neurochem. Int. (1995) [Pubmed]
  7. Stability studies of bis(pyridiniumaldoxime) reactivators of organophosphate-inhibited acetylcholinesterase. Lin, A.J., Klayman, D.L. Journal of pharmaceutical sciences. (1986) [Pubmed]
  8. In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase. Kuca, K., Cabal, J., Kassa, J., Jun, D., Hrabinova, M. J. Toxicol. Environ. Health Part A (2006) [Pubmed]
  9. In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity. Calić, M., Vrdoljak, A.L., Radić, B., Jelić, D., Jun, D., Kuca, K., Kovarik, Z. Toxicology (2006) [Pubmed]
  10. Influence of trimedoxime bromide on degradation of benactyzine in acidic injectable solutions. Rubnov, S., Amisar, S., Lomnicky, Y., Schneider, H. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (1999) [Pubmed]
  11. Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos. Antonijević, B., Bokonjić, D., Stojiljković, M.P., Kilibarda, V., Milovanović, Z.A., Nedeljković, M., Maksimović, M. Basic & clinical pharmacology & toxicology. (2005) [Pubmed]
  12. Cardiotonic drugs inhibit purified mammalian acetylcholinesterase. Hanke, D.W., Nelson, M.E., Baskin, S.I. Journal of applied toxicology : JAT. (1991) [Pubmed]
  13. In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions. Kuca, K., Cabal, J., Jun, D., Kassa, J., Bartosová, L., Kunesová, G. Journal of applied toxicology : JAT. (2005) [Pubmed]
  14. Soman induced changes in brain regional glucose use. Samson, F.E., Pazdernik, T.L., Cross, R.S., Giesler, M.P., Mewes, K., Nelson, S.R., McDonough, J.H. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1984) [Pubmed]
  15. Synthesis, biological activity, and docking studies of new acetylcholinesterase inhibitors of the bispyridinium type. Kapková, P., Stiefl, N., Sürig, U., Engels, B., Baumann, K., Holzgrabe, U. Arch. Pharm. (Weinheim) (2003) [Pubmed]
  16. Stability of mono- and bisbenzyloxime ethers of the acetylcholinesterase reactivator TMB-4. Inkmann, E., Holzgrabe, U., Hesse, K.F. Die Pharmazie. (1997) [Pubmed]
  17. Efficacy of mono- and bis-pyridinium oximes versus soman, sarin and tabun poisoning in mice. Clement, J.G. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1983) [Pubmed]
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