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Chemical Compound Review

AlnaOCAS     5-[(2R)-2-[2-(2- ethoxyphenoxy)ethylamino]p...

Synonyms: Urolosin, Secotex, Yutanal, Expros, Flomax, ...
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Disease relevance of C07124

  • CONCLUSION: Flomax appears to be effective in relieving the symptoms of radiation urethritis [1].
  • After correcting for the testing of multiple hypotheses (n = 5), the presence of benign prostatic hyperplasia (BPH) approached statistical significance for predicting the initial response to the 0.4 mg dose of Flomax (78% vs. 25%, p = 0.03) [1].
  • YM-617 caused dose-dependent decreases in renal sympathetic nerve activity along with this hypotension [2].
  • Intravenous administration of YM-617 (2, 10 and 50 micrograms/kg) produced a dose-dependent reduction in mean arterial pressure accompanied with bradycardia [2].
  • METHODS AND MATERIALS: From January 1998 to April 1998, 26 consecutive patients who developed symptoms of radiation urethritis while undergoing RT for prostate cancer were treated with Flomax, a superselective alpha1A-adrenergic antagonist [1].

High impact information on C07124

  • L(-) norepinephrine causes a time-dependent (t1/2 = 22 min) histamine release; the alpha 1-receptor antagonists WB-4101 and YM-617 specifically inhibited this release, in agreement with a mediation by alpha 1-adrenoreceptor subtype [3].
  • The present study was undertaken to elucidate the effect of YM-617 on sympathetic nerve activity and baroreceptor afferent nerve activity in anesthetized rats [2].
  • The mean pA2 value for R-(-)-YM-12617 at the alpha-1 adrenoceptor of trigone, urethra and prostate was 9.91, 9.62 and 9.92, respectively, and that for S-(+)-YM-12617 was 8.09, 7.92 and 7.77, respectively [4].
  • Intraoperative floppy-iris syndrome (IFIS) is a recently identified condition associated with phacoemulsification in patients using the alpha(1)-antagonist tamsulosin (Flomax) [5].
  • Contractions elicited by the specific alpha 1-receptor agonist phenylephrine (PE) were inhibited by the selective alpha 1-receptor antagonists prazosin and YM 617 [6].

Chemical compound and disease context of C07124


Associations of C07124 with other chemical compounds

  • The selective alpha 1-receptor agonist, phenylephrine (PE), induced fully reversible, dose-dependent contractions antagonized by increasing concentrations of the alpha 1-receptor blockers prazosin (1-100 nM) and YM 617 (0.1-10 nM) [8].


  1. Tamsulosin palliates radiation-induced urethritis in patients with prostate cancer: results of a pilot study. Prosnitz, R.G., Schneider, L., Manola, J., Rocha, S., Loffredo, M., Lopes, L., D'Amico, A.V. Int. J. Radiat. Oncol. Biol. Phys. (1999) [Pubmed]
  2. Central sympathoinhibitory action of a new type of alpha-1 adrenoceptor antagonist, YM-617, in rats. Yoshioka, M., Togashi, H., Abe, M., Ikeda, T., Matsumoto, M., Saito, H. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  3. Neurohormonal stimulation of histamine release from neuroendocrine cells of the human adenomatous prostate. Polge, A., Gaspard, C., Mottet, N., Guitton, C., Boyer, J.C., Choquet, A., Combettes, S., Bancel, E., Costa, P., Bali, J.P. Prostate (1998) [Pubmed]
  4. Alpha-1 adrenoceptor antagonist effects of the optical isomers of YM-12617 in rabbit lower urinary tract and prostate. Honda, K., Nakagawa, C. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  5. Preoperative use of atropine to prevent intraoperative floppy-iris syndrome in patients taking tamsulosin. Bendel, R.E., Phillips, M.B. Journal of cataract and refractive surgery. (2006) [Pubmed]
  6. Alpha-1 receptor mediated smooth muscle regulation in benign prostatic hyperplasia. Drescher, P., Eckert, R.E., Sparwasser, C., Madsen, P.O. Scandinavian journal of urology and nephrology. Supplementum. (1994) [Pubmed]
  7. Choroidal detachment following the use of tamsulosin (flomax). Shapiro, B.L., Petrovic, V., Lee, S.E., Flach, A., McCaffery, S., O'brien, J.M. Am. J. Ophthalmol. (2007) [Pubmed]
  8. Role of intracellular Ca2+ stores in smooth muscle contractions of the guinea pig vas deferens. Drescher, P., Eckert, R.E., Madsen, P.O. Urol. Res. (1993) [Pubmed]
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