Disease relevance of Jaceosidin

• Inhibitory effect of jaceosidin isolated from Artemisiaargyi on the function of E6 and E7 oncoproteins of HPV 16 [1].
• Flavonoids inhibit the development of the induced granuloma, mostly when a catechol or guaiacol-like B ring is contained in the compound structure, jaceosidin being the most active flavonoid screened [2].

High impact information on Jaceosidin

• The most active flavonoid was jaceosidin that inhibited cyclooxygenase-2 activity in a concentration-dependent manner with an IC50 value of 2.8 microM [3].
• In comparison with cells cultivated in shake flasks, decreased biomass and decreased jaceosidin concentration were observed when the cells were cultivated in a stirred tank bioreactor [4].
• Effect of aggregate size in cell cultures of Saussurea medusa on cell growth and jaceosidin production [4].
• All of the analyzed vervain samples showed a common flavonoid pattern, in which hispidulin and jaceosidin were the major compounds and nepetin was the minor compound [5].
• Cell cultures of Saussurea medusa produce valuable secondary metabolites, and jaceosidin and hispidulin are the major bioactive compounds [6].

Biological context of Jaceosidin

• Biomass and jaceosidin distribution in cell aggregates of different sizes were investigated during the cultivation period [4].
• Jaceosidin (4',5,7-trihydroxy-3',6-dimethoxyflavone) was isolated from Artemisia argyi as a putative oncogene inhibitor [1].

Anatomical context of Jaceosidin

• Three previously established cell lines (yellow, red and white) of Saussurea medusa were investigated for jaceosidin and hispidulin production [7].

Associations of Jaceosidin with other chemical compounds

• Addition of 20 muM salicylic acid to Saussurea medusa cell cultures at day 6 resulted in jaceosidin and syringin productions up to 95 mg l(-1 )and 631 mg l(-1) which were, respectively, about 2.5- and 2.7-fold higher than in the control [8].
• Salicylic Acid Enhances Jaceosidin and Syringin Production in Cell Cultures of Saussurea medusa [8].
• Furthermore, we observed that the activities of phenylalanine ammonia lyase were transiently increased after treatment with MJ, which suggests that this elicitor modifies jaceosidin and hispidulin production by regulating the phenylpropanoid pathway [6].
• Methyl jasmonate stimulates jaceosidin and hispidulin production in cell cultures of Saussurea medusa [6].

Gene context of Jaceosidin

• Jaceosidin inhibited binding between oncoprotein E6 of the human papillomavirus and the p53 tumor suppressor protein [1].

References