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Chemical Compound Review

Jaceosidin     5,7-dihydroxy-2-(4-hydroxy-3- methoxy...

Synonyms: JACEOSIDINE, CHEMBL487601, AG-E-30956, SureCN3960077, CHEBI:66103, ...
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Disease relevance of Jaceosidin


High impact information on Jaceosidin


Biological context of Jaceosidin

  • Biomass and jaceosidin distribution in cell aggregates of different sizes were investigated during the cultivation period [4].
  • Jaceosidin (4',5,7-trihydroxy-3',6-dimethoxyflavone) was isolated from Artemisia argyi as a putative oncogene inhibitor [1].

Anatomical context of Jaceosidin


Associations of Jaceosidin with other chemical compounds


Gene context of Jaceosidin

  • Jaceosidin inhibited binding between oncoprotein E6 of the human papillomavirus and the p53 tumor suppressor protein [1].


  1. Inhibitory effect of jaceosidin isolated from Artemisiaargyi on the function of E6 and E7 oncoproteins of HPV 16. Lee, H.G., Yu, K.A., Oh, W.K., Baeg, T.W., Oh, H.C., Ahn, J.S., Jang, W.C., Kim, J.W., Lim, J.S., Choe, Y.K., Yoon, D.Y. Journal of ethnopharmacology. (2005) [Pubmed]
  2. Acute and chronic antiinflammatory effects of plant flavonoids. Pelzer, L.E., Guardia, T., Osvaldo Juarez, A., Guerreiro, E. Farmaco (1998) [Pubmed]
  3. Flavonoids from Artemisia copa with anti-inflammatory activity. Moscatelli, V., Hnatyszyn, O., Acevedo, C., Megías, J., Alcaraz, M.J., Ferraro, G. Planta Med. (2006) [Pubmed]
  4. Effect of aggregate size in cell cultures of Saussurea medusa on cell growth and jaceosidin production. Zhao, D., Huang, Y., Jin, Z., Qu, W., Lu, D. Plant Cell Rep. (2003) [Pubmed]
  5. Analysis of vervain flavonoids by HPLC/Diode array detector method. Its application to quality control. Valentão, P., Andrade, P.B., Areias, F., Ferreres, F., Seabra, R.M. J. Agric. Food Chem. (1999) [Pubmed]
  6. Methyl jasmonate stimulates jaceosidin and hispidulin production in cell cultures of Saussurea medusa. Fu, C.X., Cheng, L.Q., Lv, X.F., Zhao, D.X., Ma, F. Appl. Biochem. Biotechnol. (2006) [Pubmed]
  7. Cellular aggregate size as the critical factor for flavonoid production by suspension cultures of Saussurea medusa. Fu, C.X., Zhao, D.X., Huang, Y., Ma, F.S. Biotechnol. Lett. (2005) [Pubmed]
  8. Salicylic Acid Enhances Jaceosidin and Syringin Production in Cell Cultures of Saussurea medusa. Yu, Z.Z., Fu, C.X., Han, Y.S., Li, Y.X., Zhao, D.X. Biotechnol. Lett. (2006) [Pubmed]
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