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Chemical Compound Review

CCRIS 5676     (1S,3R)-11-amino-1- [(2S,4S,5S,6S)-4-amino...

Synonyms: AC1NUZ6S, LS-94142, NSC254681, BRN 4069837, 5-ID, ...
 
 
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Disease relevance of 5-ID

  • (iii) 5-Iminodaunorubicin, an analogue lacking ROS-forming activity, did not induce ferritin synthesis or protect the cells against iron toxicity [1].
 

High impact information on 5-ID

 

Biological context of 5-ID

References

  1. Doxorubicin paradoxically protects cardiomyocytes against iron-mediated toxicity: role of reactive oxygen species and ferritin. Corna, G., Santambrogio, P., Minotti, G., Cairo, G. J. Biol. Chem. (2004) [Pubmed]
  2. HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive topoisomerase II. Zwelling, L.A., Slovak, M.L., Doroshow, J.H., Hinds, M., Chan, D., Parker, E., Mayes, J., Sie, K.L., Meltzer, P.S., Trent, J.M. J. Natl. Cancer Inst. (1990) [Pubmed]
  3. Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by anticancer quinones. Doroshow, J.H. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  4. Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells. Pommier, Y., Zwelling, L.A., Kao-Shan, C.S., Whang-Peng, J., Bradley, M.O. Cancer Res. (1985) [Pubmed]
  5. Electrocardiographic and transmembrane potential effects of 5-iminodaunorubicin in the rat. Jensen, R.A., Acton, E.M., Peters, J.H. Cancer Res. (1984) [Pubmed]
  6. Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide. Zwelling, L.A., Kerrigan, D., Michaels, S. Cancer Res. (1982) [Pubmed]
  7. Role of the quinone structure in the mitochondrial damage induced by antitumor anthracyclines. Comparison of adriamycin and 5-iminodaunorubicin. Pollakis, G., Goormaghtigh, E., Ruysschaert, J.M. FEBS Lett. (1983) [Pubmed]
  8. Low stimulation of NADH oxidation and oxygen consumption by 5-iminodaunorubicin and its derivatives. Tarasiuk, J., Stefańska, B., Borowski, E. Acta Biochim. Pol. (1990) [Pubmed]
 
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