High impact information on A 71378

• Similarly, none of the CCK-8 agonists (A-71623, A-71378, gastrin) modified the ascending excitation [1].
• This paper presents new findings on the effects of the biologically active CCK agonists, CCK-8S, CCK-4, and A71378 [2].
• In summary, the effect of A71378 on food intake is longer lasting compared to CCK-8S [3].
• Comparison of the satiating effect of the CCKA receptor agonist A71378 with CCK-8S [3].
• A higher ICV dose of A-71378 (5 micrograms) was also ineffective, whereas 1 microgram CCK octapeptide given ICV inhibited feeding (p < 0.03) [4].

Biological context of A 71378

• The IC50 values of A71378 for the pancreatic CCK-A, cortical CCK-B, and gastrin receptor were 0.4 nM, 300 nM, and 1,200 nM, respectively [5].
• A71378 proved to be a potent agonist in eliciting pancreatic amylase secretion (EC50 = 0.16 nM) and ileal muscle contraction (EC50 = 3.7 nM) [5].

Anatomical context of A 71378

• Characterization of A71378 was carried out in the guinea pig pancreas, cortex, gastric gland, and ileum, as well as in NCI-H345 cells [5].

Associations of A 71378 with other chemical compounds

• In Experiment 1 (n = 10), A-71378 (0.5, 1.0, and 2.0 micrograms/kg) given IV produced a sustained dose-related reduction in food intake (p < 0.02), whereas the same doses of pentagastrin were without effect [4].

Gene context of A 71378

• Herein we describe the properties of A71378 [desamino-Try(SO3H)-Nle-Gly-Trp-Nle-(N-methyl)Asp-Phe-NH2], a highly selective CCK-A receptor ligand [5].

Analytical, diagnostic and therapeutic context of A 71378

• Two and 4 h after treatment, the satiating effect of A71378 continued [3].

References