Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Epivir 4-amino-1-[(2R,5S)-2- (hydroxymethyl)-1,3...

Synonyms: lamivudine, BCH-189, BCH189, BCH 189, GR-109714X, ...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Epivir

In vitro, HIV-1 mutants resistant to 3'-azido-3'-deoxythymidine (M41L/D67N/K70R/T215Y/K219Q) and (-)beta-L-2',3'-dideoxy-3'-thiacytidine (3TC) (M184V) remain sensitive to DXG [1].
The use of L(-)SddC [beta-L-2',3'-dideoxy-3'-thiacytidine (lamivudine, 3TC)] for the treatment of Herpes B virus (HBV) infection is hindered by the emergence of drug-resistance associated with the L526M, L550V, and L526M/M550V mutations of the viral DNA polymerase (DP) [2].
2',3'-Dideoxy-2',3'-didehydro-beta-L(-)-5-fluorocytidine [L(-)Fd4C] was found to be at least 10 times more potent than beta-L-2',3'-dideoxy-3'-thiacytidine [L(-)SddC; also called 3TC, or lamivudine]against hepatitis B virus (HBV) in culture [3].
Relationship between the incidence of type 1 diabetes and enterovirus infections in different European populations: results from the EPIVIR project [4].
Lamivudine (Zeffix) is the first of a new class of antiviral agents to become available for the treatment of chronic hepatitis B [5].
In patients without cirrhosis and with decompensated cirrhosis, the preventive effects of lamivudine on the development of HCC were not observed (p=0.446 and p=0.123, respectively) [6].

High impact information on Epivir

Since single-drug treatment with AZT is being superseded by multidrug combinations, we have investigated the induction of mutations and micronuclei in mice treated neonatally with AZT, lamivudine (3'-thia-2',3'-dideoxycytidine; 3TC), or a combination of the two drugs [7].
Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)beta-L-2',3'-dideoxy-3'-thiacytidine [8].
Lamivudine (Epivir, GlaxoSmithKline) was approved by the US Food and Drug Administration for the treatment of adult patients with chronic hepatitis B in 1998, and has since been shown to be of benefit to selected patients with chronic hepatitis B [9].
Interferon-alpha and direct antiviral agents, such as lamivudine (Epivir, GlaxoSmithKline), are effective in the therapy of chronic HBV infection but the efficacy is far from satisfactory [10].
Adefovir dipivoxil is effective in patients with compensated or decompensated chronic viral B liver disease, and in pre- and post-transplant hepatitis B virus patients who develop resistance to lamivudine (Epivir, GlaxoSmithKline) [11].

Associations of Epivir with other chemical compounds

In patients with CHB resistant to lamivudine and adefovir, combination therapy with these two drugs was not effective and was inferior to entecavir monotherapy in suppressing HBV DNA [12].

Analytical, diagnostic and therapeutic context of Epivir

Quantitation of film coating on Zantac 75 mg tablets and Epivir HBV 100 mg tablets by ICP-AES [13].

References

Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses. Jeffrey, J.L., Feng, J.Y., Qi, C.C., Anderson, K.S., Furman, P.A. J. Biol. Chem. (2003) [Pubmed]
Reverse transcriptase activity of hepatitis B virus (HBV) DNA polymerase within core capsid: interaction with deoxynucleoside triphosphates and anti-HBV L-deoxynucleoside analog triphosphates. Lam, W., Li, Y., Liou, J.Y., Dutschman, G.E., Cheng, Y.C. Mol. Pharmacol. (2004) [Pubmed]
Anti-hepatitis B virus activity and metabolism of 2',3'-dideoxy-2',3'-didehydro-beta-L(-)-5-fluorocytidine. Zhu, Y.L., Dutschman, D.E., Liu, S.H., Bridges, E.G., Cheng, Y.C. Antimicrob. Agents Chemother. (1998) [Pubmed]
Relationship between the incidence of type 1 diabetes and enterovirus infections in different European populations: results from the EPIVIR project. Viskari, H., Ludvigsson, J., Uibo, R., Salur, L., Marciulionyte, D., Hermann, R., Soltesz, G., Füchtenbusch, M., Ziegler, A.G., Kondrashova, A., Romanov, A., Knip, M., Hyöty, H. J. Med. Virol. (2004) [Pubmed]
Lamivudine for the treatment of chronic hepatitis B. Dixon, J.S., Boehme, R.E. Acta Gastroenterol. Belg. (2000) [Pubmed]
Risk assessment for the development of hepatocellular carcinoma: according to on-treatment viral response during long-term lamivudine therapy in hepatitis B virus-related liver disease. Eun, J.R., Lee, H.J., Kim, T.N., Lee, K.S. J. Hepatol. (2010) [Pubmed]
Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in B6C3F(1)/Tk+/- mice treated neonatally with zidovudine and lamivudine. Von Tungeln, L.S., Hamilton, L.P., Dobrovolsky, V.N., Bishop, M.E., Shaddock, J.G., Heflich, R.H., Beland, F.A. Carcinogenesis (2002) [Pubmed]
Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)beta-L-2',3'-dideoxy-3'-thiacytidine. King, R.W., Ladner, S.K., Miller, T.J., Zaifert, K., Perni, R.B., Conway, S.C., Otto, M.J. Antimicrob. Agents Chemother. (1998) [Pubmed]
Lamivudine for chronic hepatitis B. Leung, N. Expert review of anti-infective therapy. (2004) [Pubmed]
Thymalfasin for the treatment of chronic hepatitis B. Chien, R.N., Liaw, Y.F. Expert review of anti-infective therapy. (2004) [Pubmed]
Adefovir dipivoxil in the treatment of chronic hepatitis B virus infection. Hadziyannis, S.J., Papatheodoridis, G.V. Expert review of anti-infective therapy. (2004) [Pubmed]
Lamivudine plus adefovir or entecavir for patients with chronic hepatitis B resistant to lamivudine and adefovir. Heo, N.Y., Lim, Y.S., Lee, H.C., Chung, Y.H., Lee, Y.S., Suh, D.J. J. Hepatol. (2010) [Pubmed]
Quantitation of film coating on Zantac 75 mg tablets and Epivir HBV 100 mg tablets by ICP-AES. Incledon, C., Paquet, C., Johnston, A., Jairam, R., Dass, L., Lam, H. Journal of pharmaceutical and biomedical analysis. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg