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Gene Review

IFNAA  -  interferon alpha-A

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Disease relevance of IFN-a


High impact information on IFN-a


Chemical compound and disease context of IFN-a


Biological context of IFN-a


Anatomical context of IFN-a


Associations of IFN-a with chemical compounds


Other interactions of IFN-a


Analytical, diagnostic and therapeutic context of IFN-a

  • Sequence analysis showed that IFN-a genes of six clones were composed of 498 nucleotides, encoding a mature polypeptide with 166 amino acids [12].
  • A highly significant difference was evident in the chi 2 test when PCR was compared with specific antigen detection or antibody evaluation (n = 19; chi 2 = 7; sensitivity = 100% vs. 63%) or with interferon alpha determination (n = 20; chi 2 = 11; sensitivity = 95% vs. 42%) [28].
  • Induction of the synthesis of the pregnancy-specific protein p70 in the endometrium by intramuscular injection of recombinant bovine interferon-alpha I1 in nonpregnant ewes [29].
  • Gelatin microspheres (ms) and gelatin/BSA (bovine serum albumin) or gelatin/alginate ms were prepared by encapsulating fluorescein isothiocyanate (FITC) labeled dextran or interferon alpha (IFN-alpha) [30].
  • Preparation and evaluation of once-a-day injectable microspheres of interferon alpha in rats [30].


  1. Localization of an antiviral site on the pregnancy recognition hormone, ovine trophoblast protein 1. Pontzer, C.H., Ott, T.L., Bazer, F.W., Johnson, H.M. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  2. Retinoic acid and interferon alpha act synergistically as antiangiogenic and antitumor agents against human head and neck squamous cell carcinoma. Lingen, M.W., Polverini, P.J., Bouck, N.P. Cancer Res. (1998) [Pubmed]
  3. Vaccinia virus B18R gene encodes a type I interferon-binding protein that blocks interferon alpha transmembrane signaling. Colamonici, O.R., Domanski, P., Sweitzer, S.M., Larner, A., Buller, R.M. J. Biol. Chem. (1995) [Pubmed]
  4. Expression of the interferon-alpha/beta-inducible bovine Mx1 dynamin interferes with replication of rabies virus. Leroy, M., Pire, G., Baise, E., Desmecht, D. Neurobiol. Dis. (2006) [Pubmed]
  5. Signal transduction pathways in the induction of 2',5'-oligoadenylate synthetase gene expression by interferon alpha/beta. Yan, C., Sehgal, P.B., Tamm, I. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  6. Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro. Migliaccio, G., Tomassini, J.E., Carroll, S.S., Tomei, L., Altamura, S., Bhat, B., Bartholomew, L., Bosserman, M.R., Ceccacci, A., Colwell, L.F., Cortese, R., De Francesco, R., Eldrup, A.B., Getty, K.L., Hou, X.S., LaFemina, R.L., Ludmerer, S.W., MacCoss, M., McMasters, D.R., Stahlhut, M.W., Olsen, D.B., Hazuda, D.J., Flores, O.A. J. Biol. Chem. (2003) [Pubmed]
  7. Possible mechanisms for reduction of circulating concentrations of progesterone by interferon-alpha in cows: effects on hyperthermia, luteal cells, metabolism of progesterone and secretion of LH. Barros, C.M., Betts, J.G., Thatcher, W.W., Hansen, P.J. J. Endocrinol. (1992) [Pubmed]
  8. Ribavirin derivatives with a hexitol moiety: synthesis and antiviral evaluation. Van Aerschot, A., Schepers, G., Busson, R., Rozenski, J., Neyts, J., De Clercq, E., Herdewijn, P. Antivir. Chem. Chemother. (2003) [Pubmed]
  9. Effect of levamisole and bovine interferon alpha 1 on bovine immune responses and susceptibility to bovine herpesvirus-1. Babiuk, L.A., Ohmann, H.B. Prog. Clin. Biol. Res. (1984) [Pubmed]
  10. The induction of interferon-alpha and interferon-beta mRNA in human natural interferon-producing blood leukocytes requires de novo protein synthesis. Cederblad, B., Gobl, A.E., Alm, G.V. J. Interferon Res. (1991) [Pubmed]
  11. Bovine interferon alpha genes. Structure and expression. Velan, B., Cohen, S., Grosfeld, H., Leitner, M., Shafferman, A. J. Biol. Chem. (1985) [Pubmed]
  12. Interferon-alpha Genes from Bos and Bubalus bubalus. Shi, X., Xia, C., Pan, B., Wang, M. Anim. Biotechnol. (2006) [Pubmed]
  13. Purification and characterization of multiple components of human lymphoblastoid interferon-alpha. Zoon, K.C., Miller, D., Bekisz, J., zur Nedden, D., Enterline, J.C., Nguyen, N.Y., Hu, R.Q. J. Biol. Chem. (1992) [Pubmed]
  14. Noncytopathic bovine viral diarrhea virus inhibits double-stranded RNA-induced apoptosis and interferon synthesis. Schweizer, M., Peterhans, E. J. Virol. (2001) [Pubmed]
  15. Interferon-tau and interferon-alpha interact with the same receptors in bovine endometrium. Use of a readily iodinatable form of recombinant interferon-tau for binding studies. Li, J., Roberts, R.M. J. Biol. Chem. (1994) [Pubmed]
  16. Reconstitution of virus-mediated expression of interferon alpha genes in human fibroblast cells by ectopic interferon regulatory factor-7. Yeow, W.S., Au, W.C., Juang, Y.T., Fields, C.D., Dent, C.L., Gewert, D.R., Pitha, P.M. J. Biol. Chem. (2000) [Pubmed]
  17. Interferon-alpha-dependent and -independent participation of accessory cells in natural killer cell-mediated lysis of HSV-1-infected fibroblasts. Feldman, M., Howell, D., Fitzgerald-Bocarsly, P. J. Leukoc. Biol. (1992) [Pubmed]
  18. Prolongation of luteal lifespan in cows by intrauterine infusion of recombinant bovine alpha-interferon. Plante, C., Hansen, P.J., Thatcher, W.W. Endocrinology (1988) [Pubmed]
  19. Down-regulation of the noradrenaline transporter by interferon-alpha in cultured bovine adrenal medullary cells. Toyohira, Y., Yanagihara, N., Minami, K., Ueno, S., Uezono, Y., Tachikawa, E., Kondo, Y., Kashimoto, T., Izumi, F. J. Neurochem. (1998) [Pubmed]
  20. The effect of tunicamycin on interferon-alpha production in a human lymphoblastoid cell line (Namalwa). Morser, J. J. Gen. Virol. (1982) [Pubmed]
  21. Ovine conceptus secretory proteins and bovine recombinant interferon alpha (1)-1 decrease endometrial oxytocin receptor concentrations in cyclic and progesterone-treated ovariectomized ewes. Vallet, J.L., Lamming, G.E. J. Endocrinol. (1991) [Pubmed]
  22. Alteration of oestrous cycle length, ovarian function and oxytocin-induced release of prostaglandin F-2 alpha by intrauterine and intramuscular administration of recombinant bovine interferon-alpha to cows. Plante, C., Thatcher, W.W., Hansen, P.J. J. Reprod. Fertil. (1991) [Pubmed]
  23. Cytokine profiles following interaction between bovine alveolar macrophages and Pasteurella haemolytica. Morsey, M.A., Van-Kessel, A.G., Mori, Y., Popowych, Y., Godson, D., Campos, M., Babiuk, L.A. Microb. Pathog. (1999) [Pubmed]
  24. Effect of interferon-alpha, interferon-gamma and tumour necrosis factor on African swine fever virus replication in porcine monocytes and macrophages. Esparza, I., González, J.C., Viñuela, E. J. Gen. Virol. (1988) [Pubmed]
  25. Stimulation of 2',5'-oligoadenylate synthetase activity in sheep endometrium during pregnancy, by intrauterine infusion of ovine trophoblast protein-1, and by intramuscular administration of recombinant bovine interferon-alpha I1. Mirando, M.A., Short, E.C., Geisert, R.D., Vallet, J.L., Bazer, F.W. J. Reprod. Fertil. (1991) [Pubmed]
  26. Inhibition of lymphocyte proliferation by bovine trophoblast protein-1 (type I trophoblast interferon) and bovine interferon-alpha I1. Skopets, B., Li, J., Thatcher, W.W., Roberts, R.M., Hansen, P.J. Vet. Immunol. Immunopathol. (1992) [Pubmed]
  27. Effect of intrauterine and intramuscular administration of recombinant bovine interferon alpha 1 on luteal lifespan in cattle. Plante, C., Hansen, P.J., Martinod, S., Siegenthaler, B., Thatcher, W.W., Pollard, J.W., Leslie, M.V. J. Dairy Sci. (1989) [Pubmed]
  28. Significance and clinical relevance of the detection of herpes simplex virus DNA by the polymerase chain reaction in cerebrospinal fluid from patients with presumed encephalitis. Guffond, T., Dewilde, A., Lobert, P.E., Caparros-Lefebvre, D., Hober, D., Wattre, P. Clin. Infect. Dis. (1994) [Pubmed]
  29. Induction of the synthesis of the pregnancy-specific protein p70 in the endometrium by intramuscular injection of recombinant bovine interferon-alpha I1 in nonpregnant ewes. Francis, H., Keisler, D.H., Roberts, R.M. J. Reprod. Fertil. (1991) [Pubmed]
  30. Preparation and evaluation of once-a-day injectable microspheres of interferon alpha in rats. Yoshikawa, Y., Komuta, Y., Nishihara, T., Itoh, Y., Yoshikawa, H., Takada, K. Journal of drug targeting. (1999) [Pubmed]
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