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Chemical Compound Review

DIPIVOXIL     [2-(6-aminopurin-9- yl)ethoxymethyl-(2,2...

Synonyms: Hepsera, Preveon, YouHeDing, CHEMBL922, PubChem14224, ...
 Cullen,  Li,  Brown,  Eisenberg,  Cundy,  Wolfe,  Toole,  Gibbs,  Peters,  Andersen,  Lynch,  Liu,  Alston-Smith,  Brosgart,  Jacobson,  Johnson,  Pollard,  Rooney,  Sherman,  Swindells,  Polsky,  Skowron,  Kuritzkes,  Thompson,  Squires,  Goodwin,  Dusak,  Tolson,  Stevens,  Yuen,  Rooney,  Shulman,  Zolopa,  Passaro,  Murlidharan,  Israelski,  Brosgart,  Miller,  Van Doren,  Shafer,  Katzenstein,  Miller,  Lamy,  Fuller,  Mulato,  Margot,  Cihlar,  Cherrington,  Zídek,  Franková,  Holý,  Boubelík,  Dráber,  Hadziyannis,  Tassopoulos,  Heathcote,  Chang,  Kitis,  Rizzetto,  Marcellin,  Lim,  Goodman,  Ma,  Brosgart,  Borroto-Esoda,  Arterburn,  Chuck,  Angus,  Vaughan,  Xiong,  Yang,  Delaney,  Gibbs,  Brosgart,  Colledge,  Edwards,  Ayres,  Bartholomeusz,  Locarnini,  Zoulim,  Ray,  Vela,  Olson,  Fridland,  van der Molen,  Sprengers,  Biesta,  Kusters,  Janssen,  Zhou,  Fielman,  Lloyd,  Chao,  Brown,  Tsiang,  Rooney,  Toole,  Gibbs,  Benhamou,  Thibault,  Vig,  Calvez,  Marcelin,  Fievet,  Currie,  Chang,  Biao,  Xiong,  Brosgart,  Poynard,  Perrillo,  Hann,  Mutimer,  Willems,  Leung,  Lee,  Moorat,  Gardner,  Woessner,  Bourne,  Brosgart,  Schiff,  Benhamou,  Bochet,  Thibault,  Calvez,  Fievet,  Vig,  Gibbs,  Brosgart,  Fry,  Namini,  Katlama,  Poynard,  Kahn,  Lagakos,  Wulfsohn,  Cherng,  Miller,  Cherrington,  Hardy,  Beall,  Cooper,  Murphy,  Basgoz,  Ng,  Deeks,  Winslow,  Toole,  Coakley,  
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Disease relevance of D01655


High impact information on D01655


Chemical compound and disease context of D01655


Biological context of D01655


Anatomical context of D01655


Associations of D01655 with other chemical compounds


Gene context of D01655


Analytical, diagnostic and therapeutic context of D01655


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  2. Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years. Hadziyannis, S.J., Tassopoulos, N.C., Heathcote, E.J., Chang, T.T., Kitis, G., Rizzetto, M., Marcellin, P., Lim, S.G., Goodman, Z., Ma, J., Brosgart, C.L., Borroto-Esoda, K., Arterburn, S., Chuck, S.L. Gastroenterology (2006) [Pubmed]
  3. Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase. Angus, P., Vaughan, R., Xiong, S., Yang, H., Delaney, W., Gibbs, C., Brosgart, C., Colledge, D., Edwards, R., Ayres, A., Bartholomeusz, A., Locarnini, S. Gastroenterology (2003) [Pubmed]
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  15. Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks. Cullen, J.M., Li, D.H., Brown, C., Eisenberg, E.J., Cundy, K.C., Wolfe, J., Toole, J., Gibbs, C. Antimicrob. Agents Chemother. (2001) [Pubmed]
  16. Safety and efficacy of adefovir dipivoxil in patients infected with lamivudine-resistant hepatitis B and HIV-1. Benhamou, Y., Thibault, V., Vig, P., Calvez, V., Marcelin, A.G., Fievet, M.H., Currie, G., Chang, C.G., Biao, L., Xiong, S., Brosgart, C., Poynard, T. J. Hepatol. (2006) [Pubmed]
  17. Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection. Shen, Y., Zhukovskaya, N.L., Zimmer, M.I., Soelaiman, S., Bergson, P., Wang, C.R., Gibbs, C.S., Tang, W.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
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  20. Inhibition of murine macrophage nitric oxide synthase expression by a pivoxil prodrug of antiviral acyclic nucleotide analogue 9-(2-phosphonomethoxyethyl)adenine. Zídek, Z., Franková, D., Holý, A., Boubelík, M., Dráber, P. Biochem. Pharmacol. (1997) [Pubmed]
  21. Effective metabolism and long intracellular half life of the anti-hepatitis B agent adefovir in hepatic cells. Ray, A.S., Vela, J.E., Olson, L., Fridland, A. Biochem. Pharmacol. (2004) [Pubmed]
  22. Management of hepatitis B patients with antiviral resistance. Fung, S.K., Lok, A.S. Antivir. Ther. (Lond.) (2004) [Pubmed]
  23. In vitro antihepadnaviral activities of combinations of penciclovir, lamivudine, and adefovir. Colledge, D., Civitico, G., Locarnini, S., Shaw, T. Antimicrob. Agents Chemother. (2000) [Pubmed]
  24. Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: clinical and genotypic predictors of virologic response. Shulman, N.S., Zolopa, A.R., Passaro, D.J., Murlidharan, U., Israelski, D.M., Brosgart, C.L., Miller, M.D., Van Doren, S., Shafer, R.W., Katzenstein, D.A. J. Acquir. Immune Defic. Syndr. (2000) [Pubmed]
  25. Topotecan is a substrate for multidrug resistance associated protein 4. Tian, Q., Zhang, J., Chan, S.Y., Tan, T.M., Duan, W., Huang, M., Zhu, Y.Z., Chan, E., Yu, Q., Nie, Y.Q., Ho, P.C., Li, Q., Ng, K.Y., Yang, H.Y., Wei, H., Bian, J.S., Zhou, S.F. Curr. Drug Metab. (2006) [Pubmed]
  26. Human immunodeficiency virus type 1 reverse transcriptase expressing the K70E mutation exhibits a decrease in specific activity and processivity. Miller, M.D., Lamy, P.D., Fuller, M.D., Mulato, A.S., Margot, N.A., Cihlar, T., Cherrington, J.M. Mol. Pharmacol. (1998) [Pubmed]
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