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WhBvgp1  -  DNA polymerase

Woodchuck hepatitis virus

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Disease relevance of WhBvgp1


High impact information on WhBvgp1


Chemical compound and disease context of WhBvgp1


Biological context of WhBvgp1


Anatomical context of WhBvgp1

  • We detected the supercoiled form of DHBV DNA, DHBV RNA transcripts similar to those in the virus-replicating liver, and DNA polymerase activity and viral DNA in corelike particles in extracts of yolk sac tissue of naturally infected eggs [21].
  • Membranous display of pre-S2 on hepatocytes was observed more often in DNA polymerase-positive patients, and their serum pre-S2 levels were significantly higher than those without it [22].
  • Transfection of this HBV variant clone into the human hepatoma cell line HepG2 resulted in the appearance of major HBV transcripts, replicative forms of viral DNA evidenced by both molecular hybridization and endogenous DNA polymerase assay, as well as the expression and secretion of HBsAg and HBcAg particles [23].
  • This paper describes an assay for hepatitis B DNA polymerase which is based on the use of phosphonoformic acid (PFA), a known inhibitor of the viral enzyme, with particulate fractions prepared from blood plasma or serum [24].
  • However, the DNA polymerase activated by calf thymus DNA was inhibited by 0.4 M KCl [25].

Associations of WhBvgp1 with chemical compounds


Analytical, diagnostic and therapeutic context of WhBvgp1


  1. Hepatitis B virus contains protein attached to the 5' terminus of its complete DNA strand. Gerlich, W.H., Robinson, W.S. Cell (1980) [Pubmed]
  2. Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis. Greenberg, H.B., Pollard, R.B., Lutwick, L.I., Gregory, P.B., Robinson, W.S., Merigan, T.C. N. Engl. J. Med. (1976) [Pubmed]
  3. Inhibition of hepatitis B DNA polymerase by intercalating agents. Hirschman, S.Z., Garfinkel, E. Nature (1978) [Pubmed]
  4. Acyclovir enhances the antiviral effect of interferon in chronic hepatitis B. Schalm, S.W., Heytink, R.A., van Buuren, H.R., de Man, R.A. Lancet (1985) [Pubmed]
  5. Production of hepatitis B virus in vitro by transient expression of cloned HBV DNA in a hepatoma cell line. Chang, C.M., Jeng, K.S., Hu, C.P., Lo, S.J., Su, T.S., Ting, L.P., Chou, C.K., Han, S.H., Pfaff, E., Salfeld, J. EMBO J. (1987) [Pubmed]
  6. Mitogen-induced replication of woodchuck hepatitis virus in cultured peripheral blood lymphocytes. Korba, B.E., Cote, P.J., Gerin, J.L. Science (1988) [Pubmed]
  7. Direct method for detecting small quantities of hepatitis B virus DNA in serum and plasma using the polymerase chain reaction. Zeldis, J.B., Lee, J.H., Mamish, D., Finegold, D.J., Sircar, R., Ling, Q., Knudsen, P.J., Kuramoto, I.K., Mimms, L.T. J. Clin. Invest. (1989) [Pubmed]
  8. Foscarnet decreases serum and liver duck hepatitis B virus DNA in chronically infected ducks. Sherker, A.H., Hirota, K., Omata, M., Okuda, K. Gastroenterology (1986) [Pubmed]
  9. Chronic hepatitis B virus infection: treatment strategies for the next millennium. Malik, A.H., Lee, W.M. Ann. Intern. Med. (2000) [Pubmed]
  10. YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study by in vitro full-length viral DNA transfection. Ono-Nita, S.K., Kato, N., Shiratori, Y., Masaki, T., Lan, K.H., Carrilho, F.J., Omata, M. Hepatology (1999) [Pubmed]
  11. Reverse transcriptase activity of hepatitis B virus (HBV) DNA polymerase within core capsid: interaction with deoxynucleoside triphosphates and anti-HBV L-deoxynucleoside analog triphosphates. Lam, W., Li, Y., Liou, J.Y., Dutschman, G.E., Cheng, Y.C. Mol. Pharmacol. (2004) [Pubmed]
  12. Comparison of properties of woodchuck hepatitis virus and human hepatitis B virus endogenous DNA polymerases. Hantz, O., Ooka, T., Vitvitski, L., Pichoud, C., Trepo, C. Antimicrob. Agents Chemother. (1984) [Pubmed]
  13. Suramin inhibits duck hepatitis B virus DNA polymerase activity. Tsiquaye, K., Zuckerman, A. J. Hepatol. (1985) [Pubmed]
  14. Efficacy of famciclovir treatment in chronic hepatitis B patients with different mutations at position 552 of the DNA polymerase gene. Wolters, L.M., Honkoop, P., Niesters, H.G., de Man, R.A. J. Hepatol. (1998) [Pubmed]
  15. Hepatitis B virus polymerase mutations during antiviral therapy in a patient following liver transplantation. Aye, T.T., Bartholomeusz, A., Shaw, T., Bowden, S., Breschkin, A., McMillan, J., Angus, P., Locarnini, S. J. Hepatol. (1997) [Pubmed]
  16. Expression of cloned hepatitis B virus DNA in human cell cultures. Hirschman, S.Z., Price, P., Garfinkel, E., Christman, J., Acs, G. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  17. Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy. Chayama, K., Suzuki, Y., Kobayashi, M., Kobayashi, M., Tsubota, A., Hashimoto, M., Miyano, Y., Koike, H., Kobayashi, M., Koida, I., Arase, Y., Saitoh, S., Murashima, N., Ikeda, K., Kumada, H. Hepatology (1998) [Pubmed]
  18. Hepatitis B virus nucleocapsid envelopment does not occur without genomic DNA synthesis. Gerelsaikhan, T., Tavis, J.E., Bruss, V. J. Virol. (1996) [Pubmed]
  19. Emergence of drug-resistant populations of woodchuck hepatitis virus in woodchucks treated with the antiviral nucleoside lamivudine. Zhou, T., Saputelli, J., Aldrich, C.E., Deslauriers, M., Condreay, L.D., Mason, W.S. Antimicrob. Agents Chemother. (1999) [Pubmed]
  20. Evidence for involvement of a ribosomal leaky scanning mechanism in the translation of the hepatitis B virus pol gene from the viral pregenome RNA. Lin, C.G., Lo, S.J. Virology (1992) [Pubmed]
  21. Duck hepatitis B virus replicates in the yolk sac of developing embryos. Tagawa, M., Robinson, W.S., Marion, P.L. J. Virol. (1987) [Pubmed]
  22. Pre-S proteins in chronic hepatitis B virus infection: markers of active viral infection. Kakumu, S., Arao, M., Mizokami, M., Orido, E., Yamamoto, M., Sakamoto, N. Am. J. Gastroenterol. (1989) [Pubmed]
  23. In vitro replication competence of a cloned hepatitis B virus variant with a nonsense mutation in the distal pre-C region. Tong, S.P., Diot, C., Gripon, P., Li, J., Vitvitski, L., Trépo, C., Guguen-Guillouzo, C. Virology (1991) [Pubmed]
  24. Phosphonoformic acid-inhibitable nucleotide incorporation as a measure of hepatitis B viral DNA polymerase activity. Lin, H.J., Kwan, J.P., Wu, P.C., Chak, W. J. Med. Virol. (1983) [Pubmed]
  25. Differential activation of hepatitis B DNA polymerase by detergent and salt. Hirschman, S.Z., Gerber, M., Garfinkel, E. J. Med. Virol. (1978) [Pubmed]
  26. Effects of adenine arabinoside on serum and intrahepatic replicative forms of duck hepatitis B virus in chronic infection. Hirota, K., Sherker, A.H., Omata, M., Yokosuka, O., Okuda, K. Hepatology (1987) [Pubmed]
  27. Effects of prednisolone/azathioprine in chronic hepatitis B viral infection. Weller, I.V., Bassendine, M.F., Murray, A.K., Craxi, A., Thomas, H.C., Sherlock, S. Gut (1982) [Pubmed]
  28. Acyclovir, oral, intravenous and combined with interferon for chronic HBeAg-positive hepatitis. Schalm, S.W., Heytink, R.A., Van Buuren, H.R., De Man, R.A. J. Hepatol. (1986) [Pubmed]
  29. A newly identified hepatitis B type virus in tree squirrels. Feitelson, M.A., Millman, I., Halbherr, T., Simmons, H., Blumberg, B.S. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  30. Maternal transmission of duck hepatitis B virus in pedigree Pekin ducks. Tsiquaye, K.N., McCaul, T.F., Zuckerman, A.J. Hepatology (1985) [Pubmed]
  31. Natural history of hepatitis B virus infection in renal transplant recipients--a fifteen-year follow-up. Dusheiko, G., Song, E., Bowyer, S., Whitcutt, M., Maier, G., Meyers, A., Kew, M.C. Hepatology (1983) [Pubmed]
  32. Analysis of DNA polymerase reaction products for detecting hepatitis B virus in serum--comparison with spot hybridization technique. Imazeki, F., Omata, M., Yokosuka, O., Matsuyama, Y., Ito, Y., Okuda, K. Hepatology (1985) [Pubmed]
  33. Hepatitis B virus DNA in the sera of HBsAg carriers: a marker of active hepatitis B virus replication in the liver. Bonino, F., Hoyer, B., Nelson, J., Engle, R., Verme, G., Gerin, J. Hepatology (1981) [Pubmed]
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