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Chemical Compound Review:

AC1L1VDZ tetrasodium; 2-oxidopropanoate;...

Synonyms: LS-87495, 10377-98-7, Sodium zirconium lactate, Zirconium sodium lactate (4:4:1), Lactic acid, sodium zirconium salt (4:4:1), ...

This record was replaced with 612.

Leininger, J.R. et al., Turk, J.L. et al., Turk, J.L. et al.

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Disease relevance of lactic acid

An ultrastructural study has been made of the allergic-type nodular granulomas that can be induced in guinea-pigs sensitised to sodium zirconium lactate [1].

High impact information on lactic acid

In two-thirds of the experiments using sodium zirconium lactate, delayed hypersensitivity-like reactions at 24 hr developed into nodular lesions which reached peak intensity at 8 days and histologically contained histiocytes with an epithelioid cell appearance and giant cells [2].
The lung lesions produced by multiple short-term intratracheal instillations of saline solutions of sodium zirconium lactate (NaZL), zirconium-aluminum-glycine hydroxychloride complex (ZAG), and aluminum chlorhydrate (ACH) in hamsters were studied by light and electron microscopy [3].

References

Ultrastructural observations on epithelioid cell granulomas induced by zirconium in the guinea-pig. Turk, J.L., Badenoch-Jones, P., Parker, D. J. Pathol. (1978) [Pubmed]
Sensitization with Cr, Ni and Zr salts and allergic type granuloma formation in the guinea pig. Turk, J.L., Parker, D. J. Invest. Dermatol. (1977) [Pubmed]
Acute lung lesions due to zirconium and aluminum compounds in hamsters. Leininger, J.R., Farrell, R.L., Johnson, G.R. Arch. Pathol. Lab. Med. (1977) [Pubmed]

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