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Chemical Compound Review:

H733293 potassium6-methyl-2,2-dioxo- oxathiazin-4...

Synonyms:

Armenta, S. et al., Nikolelis, D.P. et al., Nelson, G. et al., Hughes, A.M. et al., Rolls, B.J., et al.

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Disease relevance of Acetosulfam

Doses of 15, 30, 60, 450, 1500 and 2250 mg of acesulfame-K/kg body weight induced a positive dose-dependent significant clastogenicity (trend test alpha < 0.05) [1].

Psychiatry related information on Acetosulfam

Individual differences among 65 subjects were seen in bitter responses to acesulfame-K and saccharin [2].

High impact information on Acetosulfam

Second, using a heterologous expression system, we demonstrate that T1R2 and T1R3 combine to function as a sweet receptor, recognizing sweet-tasting molecules as diverse as sucrose, saccharin, dulcin, and acesulfame-K [3].
The sweet taste of aspartame, saccharin, and acesulfame-K has been reported to increase ratings of hunger and, after saccharin consumption, to increase food intake [4].
This work describes a technique for the rapid and sensitive electrochemical flow injection monitoring and analysis of mixtures of the artificial sweeteners acesulfame-K, cyclamate, and saccharin using stabilized systems of filter-supported bilayer lipid membranes (BLMs) [5].
However, infusions of cholecystokinin-8 into the ventromedial hypothalamus suppressed acesulfame-K ingestion in most animals, showing that the cannulae were placed in an area regulating ingestive behaviour [6].
An Equiratio Mixture Model for non-additive components: a case study for aspartame/acesulfame-K mixtures [7].

Chemical compound and disease context of Acetosulfam

Swiss Albino male mice were exposed to blends of aspartame (3.5, 35, 350mg/kg body weight) and acesulfame-K (1.5, 15 and 150mg/kg body weight) by gavage [8].

Associations of Acetosulfam with other chemical compounds

Two different strategies for sweeteners determination in tabletop samples by Fourier transform middle-infrared (FTIR) spectrometry, an off-line and a fully mechanized extraction of Aspartame and Acesulfame-K with different mixtures of chloroform and methanol, have been developed [9].

Analytical, diagnostic and therapeutic context of Acetosulfam

FTIR determination of Aspartame and Acesulfame-K in tabletop sweeteners [9].

References

In vivo cytogenetic studies on mice exposed to acesulfame-K--a non-nutritive sweetener. Mukherjee, A., Chakrabarti, J. Food Chem. Toxicol. (1997) [Pubmed]
Bitter taste of saccharin and acesulfame-K. Horne, J., Lawless, H.T., Speirs, W., Sposato, D. Chem. Senses (2002) [Pubmed]
Mammalian sweet taste receptors. Nelson, G., Hoon, M.A., Chandrashekar, J., Zhang, Y., Ryba, N.J., Zuker, C.S. Cell (2001) [Pubmed]
Effects of intense sweeteners on hunger, food intake, and body weight: a review. Rolls, B.J. Am. J. Clin. Nutr. (1991) [Pubmed]
Selective continuous monitoring and analysis of mixtures of acesulfame-K, cyclamate, and saccharin in artificial sweetener tablets, diet soft drinks, yogurts, and wines using filter-supported bilayer lipid membranes. Nikolelis, D.P., Pantoulias, S. Anal. Chem. (2001) [Pubmed]
Selective effects of beta-endorphin infused into the hypothalamus, preoptic area and bed nucleus of the stria terminalis on the sexual and ingestive behaviour of male rats. Hughes, A.M., Everitt, B.J., Herbert, J. Neuroscience (1987) [Pubmed]
An Equiratio Mixture Model for non-additive components: a case study for aspartame/acesulfame-K mixtures. Schifferstein, H.N. Chem. Senses (1996) [Pubmed]
In vivo cytogenetic studies on blends of aspartame and acesulfame-K. Mukhopadhyay, M., Mukherjee, A., Chakrabarti, J. Food Chem. Toxicol. (2000) [Pubmed]
FTIR determination of Aspartame and Acesulfame-K in tabletop sweeteners. Armenta, S., Garrigues, S., de la Guardia, M. J. Agric. Food Chem. (2004) [Pubmed]

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