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Chemical Compound Review:

ACESULFAME 6-methyl-2,2-dioxo- oxathiazin-4-one

Synonyms: Acesulfamo, Acesulfamum, Acetosulfam, CHEMBL176687, HSDB 3914, ...

Hawkins, C.A. et al., Kuhn, C. et al., Liang, Y. et al., Liang, Y. et al., Leclercq, C. et al., et al.

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Disease relevance of Acetosulfam

Mean daily intake among consumers was 0.24 mg/kg body weight (bw) for cyclamate (13 subjects), 0.21 mg/kg bw for saccharin (9 subjects), 0.03 mg/kg bw for aspartame (162 subjects), and 0.02 mg/kg bw for acesulfame K (56 subjects) [1].
The effect of Acesulfame K on insulin secretion was similar to that observed by injecting or infusing the same doses of glucose (150 mg/kg) body weight for injection and 20 mg/kg body weight/min for infusion), except that no hyperglycemia was observed with Acesulfame K.(ABSTRACT TRUNCATED AT 250 WORDS)[2]

High impact information on Acetosulfam

Induction of membrane chloride currents in Xenopus laevis oocytes by the sulfonyl amide sweeteners acesulfame K and saccharin [3].
Castration and the subsequent decline in sexual behavior is accompanied by an increase in Acesulfame ingestion in the presence of a receptive female [4].
When 2.5 mM Acesulfame K was added to a medium containing somatostatin, the inhibitory effect of somatostatin was totally neutralized [5].
Here, we show by functional expression experiments in human embryonic kidney cells that saccharin and acesulfame K activate two members of the human TAS2R family (hTAS2R43 and hTAS2R44) at concentrations known to stimulate bitter taste [6].
Thus, hTAS2R43 and hTAS2R44 function as cognate bitter taste receptors and do not contribute to the sweet taste of saccharin and acesulfame K [6].

Anatomical context of Acetosulfam

Somatostatin inhibited insulin release from isolated pancreatic islets, but did not antagonize the action of Acesulfame K [5].

Associations of Acetosulfam with other chemical compounds

Treatment of castrate males with estradiol alone maintains mounting behavior (but no intromissions or ejaculations) but does not suppress ingestive behavior in the presence of a receptive female--indeed under these suboptimal hormone conditions sexual behavior appears to be reduced in the presence of Acesulfame [4].

Analytical, diagnostic and therapeutic context of Acetosulfam

The contents of acesulfame K in baked and unbaked doughs were determined by HPLC [7].

References

Intake of saccharin, aspartame, acesulfame K and cyclamate in Italian teenagers: present levels and projections. Leclercq, C., Berardi, D., Sorbillo, M.R., Lambe, J. Food additives and contaminants. (1999) [Pubmed]
The effect of artificial sweetener on insulin secretion. 1. The effect of acesulfame K on insulin secretion in the rat (studies in vivo). Liang, Y., Steinbach, G., Maier, V., Pfeiffer, E.F. Horm. Metab. Res. (1987) [Pubmed]
Induction of membrane chloride currents in Xenopus laevis oocytes by the sulfonyl amide sweeteners acesulfame K and saccharin. Bufe, B., Schmale, H., Meyerhof, W. J. Recept. Signal Transduct. Res. (2000) [Pubmed]
The influence of steroid hormones on competing sexual and ingestive behavior in the male rat. Hawkins, C.A., Everitt, B.J., Herbert, J. Physiol. Behav. (1988) [Pubmed]
The effect of artificial sweetener on insulin secretion. II. Stimulation of insulin release from isolated rat islets by Acesulfame K (in vitro experiments). Liang, Y., Maier, V., Steinbach, G., Lalić, L., Pfeiffer, E.F. Horm. Metab. Res. (1987) [Pubmed]
Bitter taste receptors for saccharin and acesulfame K. Kuhn, C., Bufe, B., Winnig, M., Hofmann, T., Frank, O., Behrens, M., Lewtschenko, T., Slack, J.P., Ward, C.D., Meyerhof, W. J. Neurosci. (2004) [Pubmed]
Baking stability of acesulfame K. Klug, C., von Rymon Lipinski, G.W., Böttger, D. Zeitschrift für Lebensmittel-Untersuchung und -Forschung. (1992) [Pubmed]

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