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Chemical Compound Review:

bupropion 1-(3-chlorophenyl)-2-(tert...

Synonyms: Budeprion, Quomem, Wellbutrin, Voxra, Zyban, ...

This record was replaced with 444.

Preskorn, S.H., Lineberry, T.W. et al., Waxmonsky, J.G., Daviss, W.B. et al., Belson, M.G. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of bupropion

Bupropion (Zyban, Wellbutrin) inhibits nicotine-induced viral reactivation in herpes simplex virus type 1 latent rabbits [1].
Bupropion (Zyban, Wellbutrin SR): reports of deaths, seizures, serum sickness [2].
We report what we believe to be the first case, in a 31-year-old woman, of erythema multiforme after administration of sustained-release bupropion (Wellbutrin SR) for treatment of depression [3].
The majority of exposures involved Wellbutrin SR; however, Wellbutrin exposures involved a higher percentage of intentional overdoses and serious clinical effects [4].

High impact information on bupropion

Data from clinical trials of bupropion (Wellbutrin), a novel antidepressant, are presented as an example [5].
A double-blind multicenter evaluation compared the antidepressant efficacy of bupropion (Wellbutrin) to both placebo and amitriptyline (Elavil, Endep) in adult patients who met DSM-III criteria for major depressive disorder [6].
OBJECTIVE:: To examine in children and adolescents the 24-hour, steady-state clinical pharmacokinetics of an extended-release (XL) formulation of bupropion (Wellbutrin XL) [7].
Other nonstimulants that have been used to treat ADHD include bupropion (Wellbutrin), the alpha-2 agonists guanfacine (Tenex) and clonidine (Catapres) as well as the tricylic antidepressants [8].

References

Bupropion (Zyban, Wellbutrin) inhibits nicotine-induced viral reactivation in herpes simplex virus type 1 latent rabbits. Myles, M.E., Azcuy, A.M., Nguyen, N.T., Reisch, E.R., Barker, S.A., Thompson, H.W., Hill, J.M. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
Bupropion (Zyban, Wellbutrin SR): reports of deaths, seizures, serum sickness. Wooltorton, E. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. (2002) [Pubmed]
Bupropion-induced erythema multiforme. Lineberry, T.W., Peters, G.E., Bostwick, J.M. Mayo Clin. Proc. (2001) [Pubmed]
Bupropion exposures: clinical manifestations and medical outcome. Belson, M.G., Kelley, T.R. The Journal of emergency medicine. (2002) [Pubmed]
Methodologic approach to adverse events applied to bupropion clinical trials. Cato, A.E., Cook, L., Starbuck, R., Heatherington, D. The Journal of clinical psychiatry. (1983) [Pubmed]
Antidepressant response and plasma concentrations of bupropion. Preskorn, S.H. The Journal of clinical psychiatry. (1983) [Pubmed]
Steady-state clinical pharmacokinetics of bupropion extended-release in youths. Daviss, W.B., Perel, J.M., Birmaher, B., Rudolph, G.R., Melhem, I., Axelson, D.A., Brent, D.A. Journal of the American Academy of Child and Adolescent Psychiatry (2006) [Pubmed]
Nonstimulant therapies for attention-deficit hyperactivity disorder (ADHD) in children and adults. Waxmonsky, J.G. Essential psychopharmacology. (2005) [Pubmed]

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