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Chemical Compound Review:

AR-1E1053 [4-hydroxy-5- (hydroxymethyl)oxolan-2...

Synonyms: AC1L19O7, AC1Q6SL7, 2-deoxy-1-o-phosphonopentofuranose

McElwain, M.C. et al., Tezuka, M. et al., Maehara, Y. et al., de Bruin, M. et al., Johansson, M., et al.

Johansson,

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Disease relevance of DEOXY-RIBOSE-1P

Synthesis of deoxyribomononucleotides in Mollicutes: dependence on deoxyribose-1-phosphate and PPi [1].
Acholeplasma laidlawii B-PG9 adenine-specific purine nucleoside phosphorylase that accepts ribose-1-phosphate, deoxyribose-1-phosphate, and xylose-1-phosphate [2].
We studied the uptake of radioactive 5-fluorouracil (FUra) by the intact cells of Ehrlich ascites tumor in the presence of various coreactants with FUra such as uridine (Urd), deoxyuridine (dUrd), ribose 1-phosphate (Rib1P), and deoxyribose 1-phosphate (dRib1P) [3].

High impact information on DEOXY-RIBOSE-1P

This suggested that the cosubstrate for TP, deoxyribose-1-phosphate, was rate limiting in the cells [4].
The Kms for the partially purified PNP with ribose-1-phosphate, deoxyribose-1-phosphate, and xylose-1-phosphate were 0.80, 0.82, and 0.81 mM, respectively [2].
Uridine phosphorylase catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate [5].
Phosphorylating activity with 2-deoxy-alpha-D-ribose 1-phosphate (dRiblP) and ATP as cofactors was more active than that with alpha D-ribose 1-phosphate (RiblP) and ATP, or 5-phospho-alpha-D-ribosyldiphosphate (PPRibP) as cofactors [6].

Biological context of DEOXY-RIBOSE-1P

PD-ECGF/TP catalyses the reversible phosphorylation of thymidine to deoxyribose-1-phosphate and thymine [7].

Associations of DEOXY-RIBOSE-1P with other chemical compounds

Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells [8].

Gene context of DEOXY-RIBOSE-1P

Role of platelet derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity and potential role of deoxyribose-1-phosphate [9].

References

Synthesis of deoxyribomononucleotides in Mollicutes: dependence on deoxyribose-1-phosphate and PPi. McElwain, M.C., Pollack, J.D. J. Bacteriol. (1987) [Pubmed]
Acholeplasma laidlawii B-PG9 adenine-specific purine nucleoside phosphorylase that accepts ribose-1-phosphate, deoxyribose-1-phosphate, and xylose-1-phosphate. McElwain, M.C., Williams, M.V., Pollack, J.D. J. Bacteriol. (1988) [Pubmed]
Increased uptake of 5-fluorouracil by Ehrlich ascites tumor cells with some additives and metabolite analysis. Tezuka, M., Chikaraishi, Y., Tamemasa, O. J. Pharmacobio-dyn. (1982) [Pubmed]
Potentiation of the antitumor activity of 5-fluorouracil in colon carcinoma cells by the combination of interferon and deoxyribonucleosides results from complementary effects on thymidine phosphorylase. Schwartz, E.L., Baptiste, N., O'Connor, C.J., Wadler, S., Otter, B.A. Cancer Res. (1994) [Pubmed]
Identification of a novel human uridine phosphorylase. Johansson, M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
Metabolism of 5-fluorouracil in various human normal and tumor tissues. Maehara, Y., Nagayama, S., Okazaki, H., Nakamura, H., Shirasaka, T., Fujii, S. Gann = Gan. (1981) [Pubmed]
Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study. Fox, S.B., Moghaddam, A., Westwood, M., Turley, H., Bicknell, R., Gatter, K.C., Harris, A.L. J. Pathol. (1995) [Pubmed]
Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells. de Bruin, M., Smid, K., Laan, A.C., Noordhuis, P., Fukushima, M., Hoekman, K., Pinedo, H.M., Peters, G.J. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
Role of platelet derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity and potential role of deoxyribose-1-phosphate. de Bruin, M., van Capel, T., Smid, K., van der Born, K., Fukushima, M., Hoekman, K., Pinedo, H.M., Peters, G.J. Nucleosides Nucleotides Nucleic Acids (2004) [Pubmed]

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