Gene Review:
TYMP - thymidine phosphorylase
Homo sapiens
Synonyms:
ECGF, ECGF1, Gliostatin, MEDPS1, MNGIE, ...
Garcia,
Blessing,
Lenz,
Darcy,
Mannel,
Miller,
Husseinzadeh,
Kamoshida,
Suzuki,
Sakurai,
Ochiai,
Kimura,
Kuwao,
Sakamoto,
Sugimoto,
Fukushima,
Tsutsumi,
Possati,
Rocchetti,
Talevi,
Beatrici,
Margiotta,
Ferrante,
Calza,
Sagrini,
Ferri,
Oguri,
Achiwa,
Bessho,
Muramatsu,
Maeda,
Niimi,
Sato,
Ueda,
Aoki,
Fujimoto,
Tamaya,
- Prognostic role of thymidylate synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor, and proliferation markers in colorectal cancer. van Triest, B., Pinedo, H.M., Blaauwgeers, J.L., van Diest, P.J., Schoenmakers, P.S., Voorn, D.A., Smid, K., Hoekman, K., Hoitsma, H.F., Peters, G.J. Clin. Cancer Res. (2000)
- 5-fluorouracil-related gene expression levels in primary colorectal cancer and corresponding liver metastasis. Kuramochi, H., Hayashi, K., Uchida, K., Miyakura, S., Shimizu, D., Vallbohmer, D., Park, S., Danenberg, K.D., Takasaki, K., Danenberg, P.V. Int. J. Cancer (2006)
- Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase. Fujiwaki, R., Iida, K., Kanasaki, H., Ozaki, T., Hata, K., Miyazaki, K. Hum. Pathol. (2002)
- Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas. Ohta, M., Kitadai, Y., Tanaka, S., Yoshihara, M., Yasui, W., Mukaida, N., Haruma, K., Chayama, K. Int. J. Oncol. (2003)
- Thymidine phosphorylase-mediated angiogenesis regulated by thymidine phosphorylase inhibitor in human ovarian cancer cells in vivo. Tsukagoshi, S., Saga, Y., Suzuki, N., Fujioka, A., Nakagawa, F., Fukushima, M., Suzuki, M. Int. J. Oncol. (2003)
- cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains. Tong, B.D., Auer, D.E., Jaye, M., Kaplow, J.M., Ricca, G., McConathy, E., Drohan, W., Deuel, T.F. Nature (1987)
- Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder. Nishino, I., Spinazzola, A., Hirano, M. Science (1999)
- Vascular endothelial growth factor is a secreted angiogenic mitogen. Leung, D.W., Cachianes, G., Kuang, W.J., Goeddel, D.V., Ferrara, N. Science (1989)
- Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency. Nishigaki, Y., Martí, R., Copeland, W.C., Hirano, M. J. Clin. Invest. (2003)
- The role of thymidylate synthase and dihydropyrimidine dehydrogenase in resistance to 5-fluorouracil in human lung cancer cells. Oguri, T., Achiwa, H., Bessho, Y., Muramatsu, H., Maeda, H., Niimi, T., Sato, S., Ueda, R. Lung Cancer (2005)
- Phase II clinical trial of capecitabine in ovarian carcinoma recurrent 6-12 months after completion of primary chemotherapy, with exploratory TS, DPD, and TP correlates: a Gynecologic Oncology Group study. Garcia, A.A., Blessing, J.A., Lenz, H.J., Darcy, K.M., Mannel, R.S., Miller, D.S., Husseinzadeh, N. Gynecol. Oncol. (2005)
- Effects of various steroids on platelet-derived endothelial cell growth factor (PD-ECGF) and its mRNA expression in uterine endometrial cancer cells. Aoki, I., Fujimoto, J., Tamaya, T. J. Steroid Biochem. Mol. Biol. (2003)
- Increased muscle nucleoside levels associated with a novel frameshift mutation in the thymidine phosphorylase gene in a Spanish patient with MNGIE. Blazquez, A., Martín, M.A., Lara, M.C., Martí, R., Campos, Y., Cabello, A., Garesse, R., Bautista, J., Andreu, A.L., Arenas, J. Neuromuscul. Disord. (2005)
- Regional localization of the human platelet-derived endothelial cell growth factor (ECGF1) gene to chromosome 22q13. Stenman, G., Sahlin, P., Dumanski, J.P., Hagiwara, K., Ishikawa, F., Miyazono, K., Collins, V.P., Heldin, C.H. Cytogenet. Cell Genet. (1992)
- Regulation of expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor in human colon carcinoma cells. Schwartz, E.L., Wan, E., Wang, F.S., Baptiste, N. Cancer Res. (1998)
- The Sp1 transcription factor contributes to the tumor necrosis factor-induced expression of the angiogenic factor thymidine phosphorylase in human colon carcinoma cells. Zhu, G.H., Lenzi, M., Schwartz, E.L. Oncogene (2002)
- Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients. Amatori, F., Di Paolo, A., Del Tacca, M., Fontanini, G., Vannozzi, F., Boldrini, L., Bocci, G., Lastella, M., Danesi, R. Pharmacogenet. Genomics (2006)
- Platelet-derived endothelial cell growth factor in human colon cancer angiogenesis: role of infiltrating cells. Takahashi, Y., Bucana, C.D., Liu, W., Yoneda, J., Kitadai, Y., Cleary, K.R., Ellis, L.M. J. Natl. Cancer Inst. (1996)
- No relationship between thymidine phosphorylase (TP, PD-ECGF) expression and hypoxia in carcinoma of the cervix. Kabuubi, P., Loncaster, J.A., Davidson, S.E., Hunter, R.D., Kobylecki, C., Stratford, I.J., West, C.M. Br. J. Cancer (2006)
- Enzyme expression profiles suggest the novel tumor-activated fluoropyrimidine carbamate capecitabine (Xeloda) might be effective against papillary thyroid cancers of children and young adults. Patel, A., Pluim, T., Helms, A., Bauer, A., Tuttle, R.M., Francis, G.L. Cancer Chemother. Pharmacol. (2004)
- Modulation of vascular endothelial growth factor and thymidine phosphorylase in normal human endometrial stromal cells. Abbas, M.M., Evans, J.J., Sykes, P.H., Benny, P.S. Fertil. Steril. (2004)
- The role of peroxisome proliferator-activated receptor gamma in bladder cancer in relation to angiogenesis and progression. Possati, L., Rocchetti, R., Talevi, S., Beatrici, V., Margiotta, C., Ferrante, L., Calza, R., Sagrini, D., Ferri, A. Gen. Pharmacol. (2000)
- Interferon induces thymidine phosphorylase/platelet-derived endothelial cell growth factor expression in vivo. Makower, D., Wadler, S., Haynes, H., Schwartz, E.L. Clin. Cancer Res. (1997)
- Expression of chemoresistance-related proteins in alpha-fetoprotein-producing adenocarcinoma of the digestive organs. Kamoshida, S., Suzuki, M., Sakurai, Y., Ochiai, M., Kimura, F., Kuwao, S., Sakamoto, K., Sugimoto, Y., Fukushima, M., Tsutsumi, Y. Oncol. Rep. (2006)
- Expression of angiogenesis factors in monolayer culture, multicellular spheroid and in vivo transplanted tumor by human ovarian cancer cell lines. Sonoda, T., Kobayashi, H., Kaku, T., Hirakawa, T., Nakano, H. Cancer Lett. (2003)
- Significance of monocyte chemotactic protein-1 and thymidine phosphorylase in angiogenesis of human cardiac myxoma. Zhang, T., Koide, N., Wada, Y., Tsukioka, K., Takayama, K., Kono, T., Kitahara, H., Amano, J. Circ. J. (2003)
- Cyclooxygenase-2 in human malignant fibrous histiocytoma: correlations with intratumoral microvessel density, expression of vascular endothelial growth factor and thymidine phosphorylase. Yamashita, H., Osaki, M., Ardyanto, T.D., Osaki, M., Yoshida, H., Ito, H. Int. J. Mol. Med. (2004)
- combination of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP) to improve angiogenic gene therapy. Bouïs, D., Boelens, M.C., Peters, E., Koolwijk, P., Stob, G., Kema, I.P., Klinkenberg, M., Mulder, N.H., Hospers, G.A. Angiogenesis (2003)