Chemical Compound Review:
Guanoxabenz 2-[(2,6-dichlorophenyl) methylideneamino]-1...
Synonyms:
- 2-Alkyl analogue of idazoxan (RX 781094) with enhanced antagonist potency and selectivity at central alpha 2-adrenoceptors in the rat. Gadie, B., Lane, A.C., McCarthy, P.S., Tulloch, I.F., Walter, D.S. Br. J. Pharmacol. (1984)
- Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1-(2,6-dichlorobenzylidene-amino)-3-hydroxyguanidine) at alpha2-adrenoceptors. I. Description of an enzymatic activity in spleen membranes. Uhlén, S., Dambrova, M., Tiger, G., Oliver, D.W., Wikberg, J.E. Biochem. Pharmacol. (1998)
- Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1-(2,6-dichlorobenzylidene-amino)-3-hydroxyguanidine) at alpha2-adrenoceptors. II. Description of a xanthine-dependent enzymatic activity in spleen cytosol. Dambrova, M., Uhlén, S., Welch, C.J., Prusis, P., Wikberg, J.E. Biochem. Pharmacol. (1998)
- alpha 2-Adrenoceptor agonists induced mydriasis in the rat by an action within the central nervous system. Berridge, T.L., Gadie, B., Roach, A.G., Tulloch, I.F. Br. J. Pharmacol. (1983)
- Identification of an N-hydroxyguanidine reducing activity of xanthine oxidase. Dambrova, M., Uhlén, S., Welch, C.J., Wikberg, J.E. Eur. J. Biochem. (1998)
- Evidence for pharmacological similarity between alpha 2-adrenoceptors in the vas deferens and central nervous system of the rat. Doxey, J.C., Gadie, B., Lane, A.C., Tulloch, I.F. Br. J. Pharmacol. (1983)
- Evidence for the existence of two forms of alpha 2A-adrenoceptors in the rat. Uhlén, S., Xia, Y., Chhajlani, V., Lien, E.J., Wikberg, J.E. Naunyn Schmiedebergs Arch. Pharmacol. (1993)
- Characterization of guanoxabenz reducing activity in rat brain. Dambrova, M., Uhlén, S., Wikberg, J.E. Pharmacol. Toxicol. (1998)
- Further evidence for the existence of two forms of alpha 2B-adrenoceptors in rat. Xia, Y., Uhlén, S., Chhajlani, V., Lien, E.J., Wikberg, J.E. Pharmacol. Toxicol. (1993)
- Formation of guanoxabenz from guanabenz in human liver. A new metabolic marker for CYP1A2. Clement, B., Demesmaeker, M. Drug Metab. Dispos. (1997)
- Neuropharmacological studies in rodents on the action of RX 781094, a new selective alpha 2-adrenoceptor antagonist. Dettmar, P.W., Lynn, A.G., Tulloch, I.F. Neuropharmacology (1983)