Disease relevance of Pentenoic acid

• Fed rats did not develop fatty liver upon similar treatment with pentenoic acid [1].
• This study shows that pentenoic acid administered to rats produces findings similar to those of Reye's syndrome and Jamaican vomiting sickness [2].
• In chronic experiments rats were injected intraperitoneally every 4 hr with 50 mg/kg body weight of pentenoic acid for 10 doses, followed by a single dose of 200 mg/kg [2].
• Pentenoic acid caused hypoglycemia in fasted rats and hyperglycemia in fed rats [2].

Psychiatry related information on Pentenoic acid

• Effects of 2-propyl 2-pentenoic acid on the acquisition of conditioned behavior with negative reinforcement in mice [3].

High impact information on Pentenoic acid

• Inhibition of mitochondrial fatty acid oxidation in pentenoic acid-induced fatty liver. A possible model for Reye's syndrome [1].
• Measurements of flavoprotein reduction in intact mitochondria indicated that neither palmitoylcarnitine nor palmitoyl CoA plus L-carnitine could elicit reduction of acyl-CoA dehydrogenase and electron transferring flavoprotein in mitochondria from rats with pentenoic acid-induced fatty liver [1].

Anatomical context of Pentenoic acid

• Liver mitochondria isolated from rats with pentenoic acid-induced fatty liver showed a persistent inhibition of fatty acid oxidation [1].

References