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Chemical Compound Review:

Frigiderm 1,2-dichloro-1,1,2,2- tetrafluoro-ethane

Synonyms: Cryoflurane, Criofluorano, Cryofluorane, Cryofluoranum, Halocarbon 114, ...

Simaan, J.A. et al., Olson, M.J. et al., Patterson, P. et al., Kontochristopoulos, G. et al., Baumann, L. et al., et al.

Baumann, Frankel, Welsh, Halem,

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Disease relevance of Frigiderm

Cryoanalgesia with dichlorotetrafluoroethane lessens the pain of botulinum toxin injections for the treatment of palmar hyperhidrosis [1].

High impact information on Frigiderm

Fluorocarbon aerosol propellants X: pharmacokinetics of dichlorotetrafluoroethane in dogs [2].
Cryoanalgesia with dichlorotetrafluoroethane spray versus ice packs in patients treated with botulinum toxin-a for palmar hyperhidrosis: Self-controlled study [3].
5% FC 11, 20% FC 12 and 20% FC 114 decreased vascular resistance of the perfused limb, as reflected by decrease in mean femoral arterial perfusion pressure, in vagotomized but not in intact preparations [4].
It may be concluded from this study that FC 11, FC 12 and FC 114 exhibit a vasodepressor activity on skeletal muscle vascular bed which is readily overcome by the hypotension-induced activation of the sympathetic system but which becomes evident when reflex activity is prevented by vagotomy [4].
Lidocaine (1.3 +/- 0.3) was significantly less painful (P < .05) on venipuncture than LPC (2.18 +/- 0.3) and DCTF (2.5 +/- 0.3) but was not significantly different than BA (1.92 +/- 0.3) [5].

Biological context of Frigiderm

Electrocardiographic changes in rats after inhalation of dichlorotetrafluoroethane, Arcton 114, C2Cl2F4 [6].
At 25%, R-12 and 1,1,2,2-tetrafluoro-1,2-dichloroethane (R-114) were of equal potency to R-134a in stimulating glycolysis: 1,1,1,2,2-pentafluoro-2-chloroethane (R-115) depressed glycolysis slightly [7].

References

Cryoanalgesia with dichlorotetrafluoroethane lessens the pain of botulinum toxin injections for the treatment of palmar hyperhidrosis. Baumann, L., Frankel, S., Welsh, E., Halem, M. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2003) [Pubmed]
Fluorocarbon aerosol propellants X: pharmacokinetics of dichlorotetrafluoroethane in dogs. Niazi, S., Chiou, W.L. Journal of pharmaceutical sciences. (1976) [Pubmed]
Cryoanalgesia with dichlorotetrafluoroethane spray versus ice packs in patients treated with botulinum toxin-a for palmar hyperhidrosis: Self-controlled study. Kontochristopoulos, G., Gregoriou, S., Zakopoulou, N., Rigopoulos, D. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2006) [Pubmed]
Hemodynamic effects of aerosol propellants. III. Vascular resistance in the canine hind limb. Simaan, J.A., Aviado, D.M. Toxicology (1976) [Pubmed]
Comparison of 4 analgesic agents for venipuncture. Patterson, P., Hussa, A.A., Fedele, K.A., Vegh, G.L., Hackman, C.M. AANA journal. (2000) [Pubmed]
Electrocardiographic changes in rats after inhalation of dichlorotetrafluoroethane, Arcton 114, C2Cl2F4. Durakovic, Z., Stilinovic, L., Bakran, I. Japanese heart journal. (1976) [Pubmed]
Modulation of glucose metabolism in isolated rat hepatocytes by 1,1,1,2-tetrafluoroethane. Olson, M.J., Reidy, C.A., Johnson, J.T. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1990) [Pubmed]

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