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Chemical Compound Review

Frigiderm     1,2-dichloro-1,1,2,2- tetrafluoro-ethane

Synonyms: Cryoflurane, Criofluorano, Cryofluorane, Cryofluoranum, Halocarbon 114, ...
 
 
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Disease relevance of Frigiderm

 

High impact information on Frigiderm

  • Fluorocarbon aerosol propellants X: pharmacokinetics of dichlorotetrafluoroethane in dogs [2].
  • Cryoanalgesia with dichlorotetrafluoroethane spray versus ice packs in patients treated with botulinum toxin-a for palmar hyperhidrosis: Self-controlled study [3].
  • 5% FC 11, 20% FC 12 and 20% FC 114 decreased vascular resistance of the perfused limb, as reflected by decrease in mean femoral arterial perfusion pressure, in vagotomized but not in intact preparations [4].
  • It may be concluded from this study that FC 11, FC 12 and FC 114 exhibit a vasodepressor activity on skeletal muscle vascular bed which is readily overcome by the hypotension-induced activation of the sympathetic system but which becomes evident when reflex activity is prevented by vagotomy [4].
  • Lidocaine (1.3 +/- 0.3) was significantly less painful (P < .05) on venipuncture than LPC (2.18 +/- 0.3) and DCTF (2.5 +/- 0.3) but was not significantly different than BA (1.92 +/- 0.3) [5].
 

Biological context of Frigiderm

References

  1. Cryoanalgesia with dichlorotetrafluoroethane lessens the pain of botulinum toxin injections for the treatment of palmar hyperhidrosis. Baumann, L., Frankel, S., Welsh, E., Halem, M. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2003) [Pubmed]
  2. Fluorocarbon aerosol propellants X: pharmacokinetics of dichlorotetrafluoroethane in dogs. Niazi, S., Chiou, W.L. Journal of pharmaceutical sciences. (1976) [Pubmed]
  3. Cryoanalgesia with dichlorotetrafluoroethane spray versus ice packs in patients treated with botulinum toxin-a for palmar hyperhidrosis: Self-controlled study. Kontochristopoulos, G., Gregoriou, S., Zakopoulou, N., Rigopoulos, D. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2006) [Pubmed]
  4. Hemodynamic effects of aerosol propellants. III. Vascular resistance in the canine hind limb. Simaan, J.A., Aviado, D.M. Toxicology (1976) [Pubmed]
  5. Comparison of 4 analgesic agents for venipuncture. Patterson, P., Hussa, A.A., Fedele, K.A., Vegh, G.L., Hackman, C.M. AANA journal. (2000) [Pubmed]
  6. Electrocardiographic changes in rats after inhalation of dichlorotetrafluoroethane, Arcton 114, C2Cl2F4. Durakovic, Z., Stilinovic, L., Bakran, I. Japanese heart journal. (1976) [Pubmed]
  7. Modulation of glucose metabolism in isolated rat hepatocytes by 1,1,1,2-tetrafluoroethane. Olson, M.J., Reidy, C.A., Johnson, J.T. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1990) [Pubmed]
 
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